A5028317856- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Advanced Fluorescence Microscopy Techniques
- Heat shock proteins research
- Immunotherapy and Immune Responses
- Mitochondrial Function and Pathology
- T-cell and B-cell Immunology
- Optical Coherence Tomography Applications
- Medicinal Plants and Neuroprotection
- Spectroscopy Techniques in Biomedical and Chemical Research
- Biochemical effects in animals
- RNA Interference and Gene Delivery
- Advanced Fiber Laser Technologies
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Selenium in Biological Systems
- Laser-Matter Interactions and Applications
- Pesticide Residue Analysis and Safety
- Hormonal and reproductive studies
- Cell death mechanisms and regulation
- Spectroscopy and Chemometric Analyses
- Monoclonal and Polyclonal Antibodies Research
- Neurogenesis and neuroplasticity mechanisms
- Contact Dermatitis and Allergies
- Cellular Mechanics and Interactions
Hungarian School Sport Federation
2023-2025
HUN-REN Wigner Research Centre for Physics
2013-2024
National Institute of Oncology
1999-2024
Karolinska Institutet
2024
Institute for Solid State Physics and Optics
2011-2021
Hungarian University of Sports Science
2021
Semmelweis University
2015
Laboratoire de physique des lasers
2015
N-Gene (Hungary)
2012-2014
Induction of heat shock protein (HSP)72 protects against obesity-induced insulin resistance, but the underlying mechanisms are unknown. Here, we show that HSP72 plays a pivotal role in increasing skeletal muscle mitochondrial number and oxidative metabolism. Mice overexpressing (HSP72Tg) control wild-type (WT) mice were fed either chow or high-fat diet (HFD). Despite similar energy intake when HSP72Tg compared with WT mice, HFD increased body weight, intramuscular lipid accumulation...
Extensive research has confirmed numerous advantages of exercise for promoting brain health. More recent studies have proposed the potential benefits lactate, by-product exercise, in various aspects function and disorders. However, there remains a gap understanding effects lactate dosage its impact on aged rodents. The present study first examined long-term three different doses intervention (2000 mg/kg, 1000 500 mg/kg) high-intensity interval training (HIIT) aging mice (20-22 months) as 1st...
The efficacy and safety of the new drug, BGP-15, were compared with placebo in insulin-resistant patients a 28-day dose-ranging study. Forty-seven nondiabetic impaired glucose tolerance randomly assigned to 4 weeks treatment 200 or 400 mg BGP-15 placebo. Insulin resistance was determined by hyperinsulinemic euglycemic clamp technique homeostasis model assessment method, β-cell function measured intravenous test. Each dose significantly increased whole body insulin sensitivity (M-1, p=0.032),...
Introduction Iron is an essential micronutrient that plays a crucial role in various biological processes. Previous studies have shown iron supplementation related to exercise performance and endurance capacity improvements. However, the underlying mechanisms responsible for these effects are not well understood. Recent suggested beneficial impact of on mitochondrial function its ability rescue under adverse stress vitro rodents. Based current knowledge, our study aimed investigate whether...
Abstract The role of Peroxisome proliferator-activated receptor-gamma coactivator alpha (PGC-1α) in fat metabolism is not well known. In this study, we compared the mechanisms muscle-specific PGC-1α overexpression and exercise-related adaptation-dependent metabolism. trained (PGC-1α Ex) wild-trained (wt-ex) mice were for 10 weeks, five times a week at 30 min per day with 60 percent their maximal running capacity. overexpressed animals exhibited higher levels Fibronectin type III...
A novel, Yb-fiber laser based, handheld 2PEF/SHG microscope imaging system is introduced. It suitable for in vivo of murine skin at an average power level as low 5 mW 200 kHz sampling rate. Amplified and compressed pulses having a spectral bandwidth 8 to 12 nm around 1030 excite the biological samples ~1.89 MHz repetition rate, which explains how high quality two-photon excitation fluorescence (2PEF) second harmonic generation (SHG) images are obtained pointer. The scanning, detection head,...
<title>Abstract</title> In this study, we investigated the potential relationship between mitochondrial network and microbiome using wild-type skeletal muscle-specific PGC-1α (Pparg coactivator 1 alpha) overexpressing mice, both with without exercise training. levels were significantly elevated in muscle and, notably, colon, which is anatomically proximal to microbiome. However, no significant changes observed cell signaling or mitochondria-related proteins within colon. On other hand, H₂O₂...
Weight gain and dysfunction of glucose lipid metabolism are well-known side effects atypical antipsychotic drugs (AAPD). Here, we address the question whether a heat-shock protein (HSP) co-inducer, insulin sensitizer drug candidate, BGP-15, can prevent AAPD-induced glucose, lipid, weight changes. We also examined how an AAPD alters HSP expression BGP-15 that expression. Four different experiments reported on interventions in human trial healthy men, rodent animal model, vitro adipocyte cell...
The interaction between the gut and brain is a great puzzle since it mediated by very complex mechanisms. Therefore, possible interactions of brain-exercise-intestine-microbiome axis were investigated in control (C, N = 6) voluntarily exercised (VE, 8) middle-aged rats. endurance capacity was assessed VO2max on treadmill, spatial memory Morris maze test, gastrointestinal motility EMG, microbiome 16S RNA gene amplicon sequencing, caveolae electron microscopy, biochemical assays used to...
Despite the intensive investigation of molecular mechanism skeletal muscle hypertrophy, underlying signaling processes are not completely understood. Therefore, we used an overload model, in which main synergist muscles (gastrocnemius, soleus) plantaris were surgically removed, to cause a significant remaining 8-month-old Wistar male rats. SIRT1-associated pro-anabolic, pro-catabolic pathways, NAD and H2S levels this overload-induced hypertrophy studied. Fourteen days resulted 43% (p < 0.01)...
Abstract Background In this study, the effect of antigen‐presenting cells (APC), peptide concentration, and CD28 costimulation on calcium signaling, induced by antigen‐specific T‐cell activation, was studied flow cytometry. Methods We used two experimental approaches, which differed in their time scale duration T cell‐APC interaction, to measure increase intracellular free levels ([Ca 2+ ] i ) activated cells: ( 1 Fluo‐3–loaded were cocentrifugation with peptide‐loaded APC kinetics...
Nonlinear microscopy techniques are being increasingly used to perform in vivo studies dermatology. These methods enable us investigate the morphology and monitor physiological process skin by use of femtosecond lasers operating red, near-infrared spectral range (680–1,300 nm). In this work we two different that require no labeling: second harmonic generation (SHG) for collagen detection coherent anti-Stokes Raman scattering (CARS) assess lipid distribution genetically obese murine skin....
Abstract Background It has been suggested that exercise training and postbiotic supplement could decelerate the progress of functional biochemical deterioration in double transgenic mice overexpresses mutated forms genes for human amyloid precursor protein (APP sw ) presenilin 1 (m146L) (APP/PS1 TG ). Our earlier published data indicated performed better than controls on Morris Maze Test parallel with decreased occurrence amyloid-β plaques hippocampus. We investigated neuroprotective...
We report on a broadly tunable, long-cavity, low-pump-threshold, pulsed Ti:Sapphire laser. The laser delivers nearly transform limited ~300 fs, ~10 nJ pulses at 22 MHz repetition rate being ideal for nonlinear microscopy.
Fluorescently labelled polyethylenimine mannose/DNA nanoparticles caused morphological and intracellular changes in Langerhans cells as studied by multiphoton laser microscopy vivo ear of knock mice expressing enhanced Green Fluorescent Protein under control langerin gene.
Low physical performance is closely associated with skeletal muscle dysfunction and metabolic disorders such as obesity, diabetes cardiovascular disease. The aim of the present study was to characterize differences in liver mitochondrial function an aged rat model congenital low high running capacity (LCR/HCR) generation 44. In addition monitoring basal succinate-mediated H<sub>2</sub>O<sub>2</sub>-induced fluorescence, NAD(P)H lipofuscin fluorescence lifetime imaging (FLIM) applied frozen...