A5102883201- Congenital Heart Disease Studies
- Cardiomyopathy and Myosin Studies
- Cardiac Arrhythmias and Treatments
- Aortic Disease and Treatment Approaches
- Mechanical Circulatory Support Devices
- Cardiac pacing and defibrillation studies
- Congenital heart defects research
- Coronary Artery Anomalies
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Protein Tyrosine Phosphatases
- Dental Health and Care Utilization
- Lysosomal Storage Disorders Research
- Infective Endocarditis Diagnosis and Management
- Tracheal and airway disorders
- Connective tissue disorders research
- Galectins and Cancer Biology
- Heart Failure Treatment and Management
- Viral Infections and Immunology Research
- Dermatological and COVID-19 studies
- Glycogen Storage Diseases and Myoclonus
- Mitochondrial Function and Pathology
- HIV/AIDS oral health manifestations
- Cardiac Valve Diseases and Treatments
- Psychosocial Factors Impacting Youth
Universitätsklinikum Gießen und Marburg
2019-2025
Justus-Liebig-Universität Gießen
2011-2023
Universitätskinderklinik
2012
Ipswich Hospital
2010
It is recognized that children with congenital heart disease (CHD) are predisposed to having poorer oral health. Therefore, the purpose of this study was evaluate effectiveness an interdisciplinary preventive hygiene program (POHP) for CHD. The aim reduction incidence dental caries, as well improvement hygiene. total number participants in 107 CHD aged between two six years. At baseline, these were compared a healthy control group (HCG) 101 similar age from five preschools Giessen, Germany....
The RASopathies are a group of genetic syndromes caused by upregulated RAS signaling. Noonan syndrome (NS), the most common entity among RASopathies, is characterized mainly short stature, cardiac anomalies and distinctive facial features. Mutations in multiple RAS-MAPK pathway-related genes have been associated with NS related phenotypes. We describe two unrelated patients presenting hypertrophic cardiomyopathy (HCM) dysmorphic features suggestive NS. One them died neonatal period because...
<h3>BACKGROUND AND PURPOSE:</h3> A uniform description of brain MR imaging findings in infants with severe congenital heart disease to assess risk factors, predict outcome, and compare centers is lacking. Our objective was uniformly describe the spectrum perioperative disease. <h3>MATERIALS METHODS:</h3> Prospective observational studies were performed at 3 European between 2009 2019. Brain preoperatively and/or postoperatively transposition great arteries, single-ventricle physiology, or...
Brain injury and neurodevelopmental impairment remain a concern in children with complex congenital heart disease (CHD). A practice guideline on neuromonitoring, neuroimaging, follow-up CHD patients undergoing cardiopulmonary bypass surgery is lacking. The aim of this survey was to systematically evaluate the current centers across Europe.
Infants with congenital heart disease are at risk of brain injury and impaired neurodevelopment. The aim was to investigate factors for perioperative lesions in infants disease.Infants transposition the great arteries, single ventricle physiology, left ventricular outflow tract and/or aortic arch obstruction undergoing cardiac surgery <6 weeks after birth from 3 European cohorts (Utrecht, Zurich, London) were combined. Brain scored on preoperative (transposition arteries N=104; physiology...
Hintergrund: Mitochondriale Kardiomyopathien beruhen auf einem muskulären Energiemangel, der durch Atmungskettendefekte verursacht ist. Ursächliche Veränderungen können sowohl in nukleären als auch mitochondrialen Genen zu finden sein. Das nukleär kodierte MALSU1 Protein spielt eine Rolle bei Bildung und Aufrechterhaltung großen Untereinheit mitochondrialer Ribosomen, die für Proteinbiosynthese verantwortlich sind.
To examine the relationship between perioperative brain injury and neurodevelopment during early childhood in patients with severe congenital heart disease (CHD).
Parents of children with congenital heart disease (CHD) seem to underestimate the importance optimized oral health. The low priority for a good hygiene and healthy diet can be risk factor odontogenic bacteremia infective endocarditis. aim this study was evaluation awareness dental knowledge parents using questionnaire. Therefore, from 107 CHD control group (HCG) consisting 101 both aged 2 6 years were asked complete questionnaire containing items about general health, behavior, preventive...
Little is known about the mid-term outcome and brain development in patients following hybrid approach for hypoplastic left heart syndrome (HLHS). This study investigates neurodevelopmental outcome, quality of life (QoL) MRI findings HLHS preschoolers treated with approach.Twenty (60% males) have been examined after neonatal Stage I comprehensive stage II operation at Pediatric Heart Center Giessen, Germany, between 2012 2016. Patients were evaluated Bayley Scales Infant Toddler Development...
Abstract Children with CHD, especially heart‐transplanted patients, are predisposed to have caries lesions, gingivitis and other oral findings like gingival hyperplasia. The aim of the study was implementation a specific hygiene program in these patients its effect on improvement health, overgrowth. For this, we used newly developed systematic GHI evaluate describe this alteration. Thirty‐three children, aged 6 15 years cardiac transplants (9 girls, 24 boys), were examined introduced into...
Background: Neonatal myocardial infarction is rare and associated with high mortality. Treatment strategies often include extracorporeal circulation as a bridge to recovery or transplant. This severe complications, especially due long organ waiting periods in this vulnerable age group.
De novo heterozygous mutations changing R179 to histidine, leucine, or cysteine in the ACTA2 gene are associated with Multisystemic Smooth Muscle Dysfunction Syndrome (MSMDS). Characteristic hallmarks of this condition, caused only by these specific mutations, congenital mydriasis (mid‐dilated, non‐reactive pupils), a large persistent ductus arteriosus (PDA), aortic aneurysms evolving during childhood, and cerebrovascular anomalies. We describe two patients, 3‐day‐old newborn 26‐year‐old...
Abstract OBJECTIVES Children with univentricular congenital heart disease undergoing staged surgical palliation are at risk for impaired neurodevelopmental (ND) outcome. Little is known about the long-term effects on brain growth until school age. METHODS In a prospective two-centre study, consecutive patients stage I (Hybrid or Norwood) to III (Fontan procedure) were evaluated by 2 serial cerebral magnetic resonance imaging examinations, somatic and ND testing before Fontan procedure years...
s of the 51st Workshop for Pediatric Research Gottingen, Germany 16-17 April 2015 This supplement has not been sponsored. Meeting abstracts Background Dilated cardiomyopathy (DCM) is a leading cause cardiac death in children. Approximately 30% children die or need transplantation first year after diagnosis. We established protocol to improve outcome this high-risk population. Patients and methods present our experience 21 patients (mean age 8 month, mean weight 6 kg) treated institution from...
Infants with Congenital Heart Disease (CHD) are at risk of neurodevelopmental impairments. MRI studies have identified brain injury in infants CHD both before and after cardiac surgery. We characterized factors for preoperative new postoperative arterial ischaemic stroke (AIS), white matter (WMI) cerebral sinovenous thrombosis (CSVT) a cohort severe CHD. Balloon atrial septostomy was associated increased injury. Induced vaginal delivery WMI. Cardiac physiology perioperative were
Aims: LEOPARD syndrome is a rare congenital disorder mainly characterised by skin, facial, and cardiac anomalies. Multiple lentigines are pathognomonic features, but frequently not manifest before the age of 4–5 years.