A5033790908- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cytokine Signaling Pathways and Interactions
- Gut microbiota and health
- Gastrointestinal motility and disorders
- RNA modifications and cancer
- Meteorological Phenomena and Simulations
- Cancer-related Molecular Pathways
- Aeolian processes and effects
- Acupuncture Treatment Research Studies
- Remote Sensing and Land Use
- Cancer-related molecular mechanisms research
- Gastrointestinal Tumor Research and Treatment
- Remote Sensing in Agriculture
- Remote Sensing and LiDAR Applications
- Gastric Cancer Management and Outcomes
- Organometallic Complex Synthesis and Catalysis
- Environmental and Agricultural Sciences
- Pharmacological Effects and Toxicity Studies
- COVID-19 and Mental Health
- Cancer Mechanisms and Therapy
- Plant Ecology and Soil Science
- Vehicle emissions and performance
- COVID-19 Clinical Research Studies
- Environmental Changes in China
First Affiliated Hospital of Xi'an Jiaotong University
2021-2025
Sun Yat-sen University
2015-2024
First Affiliated Hospital of Henan University
2024
Jilin University
2010-2023
Children’s Hospital of Fudan University Xiamen Branch
2023
Sun Yat-sen University Cancer Center
2015-2023
Guiyang Medical University
2021-2023
University of Kentucky
2023
Affiliated Hospital of Guizhou Medical University
2023
Third Xiangya Hospital
2023
Dysbiosis of gut microbiota are commonly reported in autism spectrum disorder (ASD) and may contribute to behavioral impairment. Vitamin A (VA) plays a role regulation microbiota. This study was performed investigate the VA changes functions children with ASD. Sixty four, aged 1 8 years old ASD completed 6-month follow-up intervention. High-performance liquid chromatography used assess plasma retinol levels. The Autism Behaviour Checklist (ABC), Childhood Rating Scale (CARS) Social...
Aim: This study analyzes the effects of retrospective stressful life events on current depression among Chinese older people and how these are moderated by social support. Stressful comprise bereavement, divorce, health adversities, accidents, financial losses due to fraud. Data Method: were drawn from China Health Retirement Longitudinal Study (CHARLS) 2015 panel, responses 9,619 aged over 60 years used. The least-squares regression method was applied measure linear effects. Propensity...
Nonalcoholic fatty liver disease (NAFLD) is among the most prevalent chronic diseases around globe. The accumulation of lipids in and oxidative stress are important pathological mechanisms NAFLD. Astaxanthin (AT) a carotenoid extracted from shrimps crabs with beneficial biological activities, including anti-oxidative anti-inflammatory activities. 16S microflora sequencing, H&E staining, western blot technique were employed to investigate impacts AT on high-fat diet (HFD)-induced Significant...
Abstract Pancreatic adenocarcinoma, one of the worst malignancies exocrine pancreas, is a solid tumor with increasing incidence and mortality in industrialized countries. It usually driven by oncogenic Kras point mutations evolves into highly aggressive metastatic carcinoma due to secondary gene specific signaling pathways unbalance. To examine vivo effects KrasG12D during pancreatic cancer progression time correlation activities, we have generated zebrafish model adenocarcinoma which...
Abstract. Quantifying the transport flux (TF) of atmospheric pollutants plays an important role in understanding causes air pollution and making decisions regarding prevention control regional pollution. In this study, mixing layer height (MLH) wind profile were measured by a ceilometer Doppler radar, respectively, characteristics dilution capability analyzed using these two datasets. The ventilation coefficient (VC) appears to be highest spring (3940±2110 m2 s−1) lower summer (2953±1322...
Aims: To evaluate the influences of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tacrolimus concentration in early postrenal transplant recipients. Patients & methods: A total 159 patients were included, dose-adjusted trough day 7 after transplantation (C0D7/D) was calculated 10 SNPs four genes genotyped. Results: CYP3A5*3 explained 32.8% variability C0D7/D. CYP3A4*1G, 1236–2677–3435 diplotype -25385C > T 21.4% C0D7/D CYP3A5 nonexpressers. Conclusion: predominant determinant affecting...
Background The COVID-19 outbreak has increased challenges associated with health management, especially cancer management. In an effort to provide continuous pharmaceutical care patients, Sun Yat-sen University Cancer Center (SYSUCC) implemented a remote pharmacy service platform based on its already existing web-based hospital app known as Cloud SYSUCC. Objective aim of this study was investigate the characteristics, acceptance, and initial impact SYSUCC during in tertiary China. Methods...
Background: Hyperbaric oxygen therapy (HBOT) has been widely used in the clinical setting. In this study, HBOT was evaluated for its ability to ameliorate epithelial-to-mesenchymal transition (EMT) phenomenon keloid tissue. Methods: Keloid patients were randomly divided into two groups: (K group, 9 patients) and receiving (O patients). A third group with normal skin (S established control. Before surgery, a laser Doppler flowmeter measure blood supply of O group. Hematoxylin eosin (H&E)...
Although somatic mutations were explored in depth, limited biomarkers found to predict the resistance of EGFR tyrosine kinase inhibitors (EGFR-TKI). Previous studies reported N6-methyladenosine (m6A) levels regulated response EGFR-TKIs; whether germline variants located m6A sites affected EGFR-TKIs is still unknown.
In-wheel motor-driven vehicles are the development trend for future due to its high energy efficiency and low emission as well flexibility achieve independent steering, driving, etc. However, weighted wheel of in-wheel electric involves more unexpected unsprung vibrations, which imposes adverse effect on vehicle ride comfort. In addition, there exists an invariant point around resonance frequency in both controlled uncontrolled suspensions, greatly limits elimination vehicles. this paper, a...
Ribosomal proteins are known to be required for proper assembly of mature ribosomes. Recent studies indicate an additional role ribosomal as candidate tumor suppressor genes. Pancreatic acinar cells, recently identified effective cells origin pancreatic adenocarcinoma, display especially high-level expression multiple proteins. We, therefore, functionally interrogated the ability two proteins, rpl36 and rpl23a, alter response oncogenic Kras in using a newly established model zebrafish...
While China has decreasing female labor participation and increasing marital instability, compared to the rest of world, its rate is higher on average. The effect force status couples' satisfaction, as one main factors for evaluating quality, been separately discussed, including extensive margins considering whether women are in market intensive working hours per week. This study analyzed data from 2014 Family Panel Studies (CFPS) using a binary logit model stability test. Results showed...
Vitamin A deficiency (VAD) remains a public health issue worldwide, affecting pregnant women and children. The early-life microbiota is potentially effective intervention target for modulating immune metabolic development of the host. This paper investigates effects VAD during different life periods on structure colonic mucosa in adolescent rats. results showed that concentrations serum retinol were > ~1.05 μmol/L maternal VA normal (VAN)rats < 0.7 rats, while levels higher...
The cyclin groove is an important recognition site for substrates of the cell cycle dependent kinases and provides opportunity highly selective inhibition kinase activity through a non-ATP competitive mechanism. key peptide residues binding motif have been studied in order to precisely define structure-activity relationship CDK inhibition. Through this information, new insights into interactions inhibitors with subsites provide replacement determinants more druglike functionality REPLACE,...
Abstract The use of target agents and immune checkpoint inhibitors have changed the treatment landscape for AGC in first-line setting. However, crosswise comparison between each regimen is rare. Therefore, we estimated efficacy safety targeted therapy or immunotherapy with chemotherapy patients as treatment. Included studies were divided into “average” “specific positivity” group according to whether selected by a certain pathological expression. We conducted Bayesian network meta-analysis...