A5016188907- Cardiovascular and exercise physiology
- Sports Performance and Training
- Exercise and Physiological Responses
- melanin and skin pigmentation
- Cancer Genomics and Diagnostics
- Skin Protection and Aging
- Cardiovascular Effects of Exercise
- Muscle metabolism and nutrition
- Ovarian cancer diagnosis and treatment
- DNA Repair Mechanisms
- Thermoregulation and physiological responses
- Olfactory and Sensory Function Studies
- RNA regulation and disease
- Heart Rate Variability and Autonomic Control
- Winter Sports Injuries and Performance
- Physical Activity and Health
- Sports injuries and prevention
- High Altitude and Hypoxia
- Forensic and Genetic Research
- Gene expression and cancer classification
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Adrenal and Paraganglionic Tumors
- Genetically Modified Organisms Research
- Reproductive System and Pregnancy
Spanish National Cancer Research Centre
2021-2025
Centro Nacional de Investigaciones Científicas
2023
Universitat Jaume I
2012-2022
Altera (United States)
2020
Universitat de Barcelona
2016
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016
Departamento de Educación
2016
Universitat de València
2016
Hospitales Nisa
2016
University of Girona
2016
Phytohormones are central players in sensing and signaling numerous environmental conditions like drought stress. In this work, an experimental system based on severe was established hormone profiling together with gene expression of key enzymes involved abscisic acid (ABA) jasmonic (JA) biosynthesis studied roots citrumelo CPB 4475 (a commercial citrus rootstock) plants. JA concentration transiently increased after a few hours stress, returning to control levels 30 h the onset condition. A...
Abstract The mechanisms triggering metastasis in pheochromocytoma/paraganglioma are unknown, hindering therapeutic options for patients with metastatic tumors (mPPGL). Herein we show by genomic profiling of a large cohort mPPGLs that high mutational load, microsatellite instability and somatic copy-number alteration burden associated ATRX / TERT alterations suitable prognostic markers. Transcriptomic analysis defines the signaling networks involved acquisition competence establishes gene...
High-grade serous ovarian carcinoma (HGSOC) is the most genomically complex cancer, characterized by ubiquitous
Oxidative stress has been widely studied in association to ultra-endurance sports. Although it is clearly demonstrated the increase reactive oxygen species and free radicals after these extreme endurance exercises, effects on antioxidant defenses oxidative damage macromolecules, remain be fully clarified. Therefore, aim of this study was elucidate impact an ultramarathon race plasma markers 32 runners their post-race recovery, with especial focused sex age effect. For purpose, enzymes...
Human pigmentation is a polygenic quantitative trait with high heritability. In addition to genetic factors, it has been shown that can be modulated by oestrogens and androgens via up- or down-regulation of melanin synthesis. Our aim was identify possible sex differences in phenotype as well melanoma association case-control population Spanish origin.Five hundred ninety-nine females (316 cases 283 controls) 458 males (234 224 were analysed. We genotyped 363 polymorphisms (single nucleotide...
Abstract Cytotoxic chemotherapies are typically administered without the use of precision biomarkers. As such, many patients can experience severe toxic side effects any benefit. Here, we present a set chromosomal instability (CIN) signature biomarkers that identify resistant to platinum-, taxane-, and anthracycline-based treatment using single genomic test. We leveraged real-world cohorts retrospectively emulate series biomarker clinical trials across total 740 patients. In emulations where...
The study aimed at assessing the acute physiological effects of running a 65-km vs 107-km mountain ultramarathon. Nineteen athletes (15 males and 4 females) from shorter race forty three (26 17 longer were enrolled. Body weight, respiratory lower limb strength assessed before after race. Blood samples obtained before, 24-h post-race. weight loss did not differ between races. A decrease in squat jump height (p<0.01; d = 1.4), forced vital capacity 0.5), expiratory volume 1 s 0.6), peak...
Cancer-related systemic inflammation has been associated with prognosis in multiple cancer types. Conversely, local inflammation, which is characterized by dense intratumoral immune infiltrates, a favorable predictor of survival outcome. However, these associations are not well established ovarian cancer, particularly the less frequent endometrioid and clear cell endometriosis histotypes.This retrospective study included 119 patients (63 56 carcinomas). We performed comprehensive association...
The purpose of this study was to establish GENEA (Gravity Estimator Normal Everyday Activity) cut-points for discriminating between six relative-intensity activity levels in middle-aged recreational marathoners. Nighty-eight (83 males and 15 females) marathoners, aged 30–45 years, completed a cardiopulmonary exercise test running on treadmill while wearing accelerometer their non-dominant wrist. breath-by-breath V̇O2 data also collected criterion measure physical categories (sedentary,...
Abstract Biological therapies are safer and more effective against psoriasis than conventional treatments. Even so, 30–50% of psoriatic patients show an inadequate response, which is associated with individual genetic heterogeneity. Pharmacogenetic studies have identified several single nucleotide polymorphisms (SNPs) as possible predictive prognostic biomarkers for treatment response. The objective this study was to determine the link between SNPs clinical response biological in...
Abstract As long-distance races have substantially increased in popularity over the last few years, improvement of training programs has become a matter concern to runners, coaches and health professionals. Triaxial accelerometers been proposed as one most accurate tools evaluate physical activity during free-living conditions. In this study, eighty-eight recreational marathon aged 30–45 completed wearing GENEActiv accelerometer on their non-dominant wrist. Energy consumed by each runner was...
Martínez-Navarro, I, Montoya-Vieco, A, Collado, E, Hernando, B, Panizo, N, and C. Muscle Cramping in the marathon: Dehydration electrolyte depletion vs. muscle damage. J Strength Cond Res 36(6): 1629-1635, 2022-Our aim was to compare dehydration variables, serum electrolytes, damage markers between runners who suffered exercise-associated cramps (EAMC) did not suffer EAMC a road marathon. We were also interested analyzing race pacing training background. Nighty-eight marathoners took part...
Telomere shortening, a well-known biomarker of aging, is complex process influenced by several intrinsic and lifestyle factors. Although habitual exercise may promote telomere length maintenance, extreme endurance has been also associated with increased oxidative stress-presumed to be the major cause shortening. Therefore, pace shortening age depend on antioxidant system efficiency, which is, in part, genetically determined. In this study, we aimed evaluate impact ultra-endurance stress...
The study aimed to assess the relationship between peak oxygen uptake, ventilatory thresholds and maximal fat oxidation with ultra trail male female performance. 47 athletes (29 men 18 women) completed a cardiopulmonary exercise test 2 4 weeks before 107-km trail. Body composition was also analyzed using bioelectrical impedance weight scale. Exploratory correlation analyses showed that uptake (men: r=-0.63, p=0.004; women: r=-0.85, p < 0.001), speed r=-0.74, 0.001; r=-0.69, p=0.009), at...
Martínez-Navarro, I, Chiva-Bartoll, O, Hernando, B, Collado, E, Porcar, V, and C. Hydration status, executive function response to orthostatism after a 118-km mountain race: are they interrelated? J Strength Cond Res 32(2): 441-449, 2018-The present study aimed explore whether blood pressure (BP) heart rate (HR) variability (HRV) responsiveness orthostatism, jointly with (EF) performance, was diminished an ultra-endurance race. Besides, we wanted assess hydration status related either...
In recent years, increasing numbers of women have participated in extremely long races. adult males, there is a clear association between physiological levels endogenous sex hormones and physical performance. However, the influence plasmatic effects different types hormonal contraception (HC) on modulation performance females remain to be fully clarified. Eighteen female ultra-endurance athletes were recruited participate study. Different variables studied, including hematological...
Summary Background/Purpose Recent GWAS studies, mostly performed in populations of North European origin, have identified the genetic loci associated with pigmentation, sun sensitivity, freckling and skin cancer susceptibility. Here, we aimed at addressing determinants sunlight sensitivity Spain, a southern population. Methods Nine SNP s located 8 pigmentation‐related genes ( IRF 4, TYR , ASP HERC 2, OCA BNC SLC 24A4 45A2 ) were genotyped 456 Spaniards. Additionally, complete sequence MC 1R...
Abstract Sunlight exposure induces signalling pathways leading to the activation of melanin synthesis and tanning response. Micro RNA s (mi s) can regulate expression genes involved in pigmentation by binding complementary sequence their 3′untranslated regions (3′ UTR s). Therefore, 3′ SNP are predicted modify ability mi target genes, resulting differential gene expression. In this study, we investigated role sun‐sensitivity traits, as well melanoma susceptibility, 38 different from...