A5061479895- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Breastfeeding Practices and Influences
- Mechanical Circulatory Support Devices
- Tryptophan and brain disorders
- Birth, Development, and Health
- Stress Responses and Cortisol
- Respiratory Support and Mechanisms
- Clinical Nutrition and Gastroenterology
- Body Composition Measurement Techniques
- Infant Development and Preterm Care
- Congenital Diaphragmatic Hernia Studies
- Fatty Acid Research and Health
- Congenital Heart Disease Studies
- Metabolism and Genetic Disorders
- Sepsis Diagnosis and Treatment
- Vitamin D Research Studies
- Family and Patient Care in Intensive Care Units
- Child Nutrition and Water Access
- Intensive Care Unit Cognitive Disorders
- Child Nutrition and Feeding Issues
- Pregnancy and Medication Impact
- Muscle metabolism and nutrition
- Digestive system and related health
- Cardiac Arrest and Resuscitation
McMaster University
2016-2025
Impact
2021-2025
Hamilton Health Sciences
2022-2025
McMaster Children's Hospital
2021-2024
Nuremberg Hospital
2020
Universität Greifswald
2005-2018
Universitätsmedizin Greifswald
2005-2018
University Children’s Hospital Basel
2014
Universitäres Kinderwunschzentrum Lübeck
2014
University Hospital Schleswig-Holstein
2014
Significant biological variation in macronutrient content of breast milk is an important barrier that needs to be overcome meet nutritional preterm infants. To analyze content, commercial infrared analyzers have been proposed as efficient and practical tools terms efficiency practicality. Since were originally developed for the dairy industry, they must validated using a significant number human samples represent broad range term milk. Aim this study was validate two analysis with reference...
ABSTRACT The nutritional status of pregnant women is vital for healthy outcomes and a concern large proportion the world's population. role microbiota in pregnancy nutrition promising new area study with potential health ramifications. In many African countries, maternal infant death morbidity are associated malnutrition. Here, we assess influence probiotic yogurt containing Lactobacillus rhamnosus GR-1, supplemented Moringa plant as source micronutrients, on oral, gut, vaginal, milk...
Appropriate use of antibiotics is life-saving in neonatal early-onset sepsis (EOS), but overuse associated with antimicrobial resistance and long-term adverse outcomes. Large international studies quantifying early-life antibiotic exposure along EOS incidence are needed to provide a basis for future interventions aimed at safely reducing exposure.To compare early postnatal antibiotics, EOS, mortality among different networks high-income countries.This retrospective, cross-sectional study...
It is increasingly recognized that psychological stress influences inflammatory responses and mood. Here, we investigated whether (combined acoustic restraint stress) activates the tryptophan (Trp) catabolizing enzyme indoleamine 2,3-dioxygenase 1(IDO1) thereby alters immune homeostasis behavior in mice. We measured IDO1 mRNA expression plasma levels of Trp catabolites after a single 2-h session repeatedly stressed (4.5-days stress, twice day) naïve BALB/c A role cytokines acute...
Stress is a powerful modulator of neuroendocrine, behavioral, and immunological functions. After 4.5-d repeated combined acoustic restraint stress as murine model chronic psychological stress, severe metabolic dysregulations became detectable in female BALB/c mice. Stress-induced alterations processes that were found hepatic mRNA expression profiling verified by vivo analyses. Repeatedly stressed mice developed hypermetabolic syndrome with the loss lean body mass, hyperglycemia,...
In preterm infants, natural variation of breast milk composition makes it difficult to achieve recommended macronutrient intakes with standard fortification. Evidence suggests that nutritional deficiency induces poor postnatal growth. This study investigates impacts target fortification on growth and metabolism by adjusting macronutrients.This was conducted as a single-centre, double-blind, randomized controlled trial for infants <30 gestational weeks. The control group received the...
Abstract The t(14;18) translocation is a common genetic aberration that can be seen as an early step in pathogenesis of follicular lymphoma (FL). significance low level circulating t(14;18)‐positive cells healthy individuals clonal precursors or indicators risk still unclear. We determined the age dependent prevalence and frequency BCL2/IgH rearrangements 715 ranging from newborns to octo‐ nonagenarians. These results were compared with number 108 FL patients at initial presentation. overall...
The correct assessment of energy expenditure (EE) in athletes is important to ensure that dietary intake sufficient. In general, are individuals with especially high levels total EE (TEE) and exercise-related (ExEE). SenseWear Pro3 Armband (SWA) a multisensor device for the individual EE, but data on validity higher exercise intensities missing. aim study was validate SWA TEE ExEE endurance athletes.The worn by 14 male 7 d during regular training period, measured parallel doubly labeled...
This paper reports the development of microfluidic oxygenator (MFO) units designed for a lung assist device (LAD) newborn infants. will be connected to umbilical vessels like natural placenta and provide gas exchange. The extracorporeal blood flow is only driven by pressure difference between artery vein without use external pumps. LAD in ambient air (∼21% 760 mmHg). main focus this presentation MFO testing various membrane materials with human enhance exchange design fluidic inlets lower...
Abstract A miniaturized oxygenator device that is perfused like an artificial placenta via the umbilical vessels may have significant potential to save lives of newborns with respiratory insufficiency. Recently we presented concept integrated modular lung assist ( LAD ) consists stacked microfluidic single units SOU s) and demonstrated technical details operation prototypes. In this article, present a prototype designed accommodate different needs term preterm infants by permitting changing...
Growth of preterm infants is monitored using fetal charts despite individual trajectories being downshifted postnatally by adaptational processes. The study aims to compare different approaches create individualized postnatal trajectories.Three achieve growth similar healthy term at 42+0/7 weeks postmenstrual age (PMA) on World Health Organization standards (WHOGS) (target weight) were tested comparing obtained by: 1) following birth percentiles (Birth-Weight-Percentile Approach); 2)...
Systemic application of mesenchymal stromal cells (MSCs) in inflammatory cardiomyopathy exerts cardiobeneficial effects. The mode action is unclear since a sufficient and long-acting cardiac homing MSCs unlikely. We therefore investigated the regulation immune response coxsackievirus B3 (CVB3)-induced acute myocarditis after intravenous MSCs. Wildtype mice were infected with CVB3 treated either PBS, human or fibroblasts intravenously 1 day infection. Seven days infection, could be detected...
It has recently been shown that an increased plasma level of the tryptophan catabolite kynurenine is early indicator for development sepsis in major trauma patients. We examined predictive value pathway activity ongoing patients being admitted to a surgical intensive care unit different reasons. In addition, we asked whether accumulation kynurenines patients’ depends on reduced renal clearance. conducted prospective observational study including 100 consecutive and monitored laboratory...
A well-balanced immunological interaction between mother and the semi-allogenic embryo is of particular importance. The objective present study was to analyse mechanisms immune tolerance in bovine pregnancy during peri-implantation. Simmental heifers inseminated with either cryopreserved spermatozoa or seminal plasma were killed 12, 15 18 days after oestrus. Uteri flushed for recovery conceptuses ipsilateral intercaruncular endometrium sampled gene expression analysis. Indoleamine...
Target fortification (TFO) reduces natural macronutrient variation in breast milk (BM). Daily BM analysis for TFO increases neonatal intensive care unit work load by 10–15 min/patient/day and may not be feasible all nurseries. The of intake when is done various schedules was studied. In an observational study, we analyzed 21 subsequent samples native 24-h batches, which had been prepared 10 healthy infants (gestational age 26.1 ± 1.3 weeks, birth weight: 890 210 g). Levels protein fat...
Preterm neonates suffering from respiratory distress syndrome require assistive support in the form of mechanical ventilation or extracorporeal membrane oxygenation, which may lead to long-term complications even death. Here, we describe a high performance artificial placenta type microfluidic oxygenator, termed as double-sided single oxygenator unit (dsSOU), combines microwire stainless-steel mesh reinforced gas permeable membranes on both sides microchannel network, thereby significantly...
BackgroundHuman milk analyzers are increasingly used to rapidly measure the macronutrient content in breast for individual target fortification, reduce risk of postnatal growth restriction. However, many without calibration, validation or quality assurance.AimsTo investigate measurement between different human analyzers, test whether accuracy and precision devices can be improved by establishing calibration curves, assess long-term stability measurements, following good clinical laboratory...
For preterm infants, it is common practice to add human milk fortifiers native breast enhance protein and calorie supply because the growth rates nutritional requirements of infants are considerably higher than those term infants. However, macronutrient intake may still be inadequate composition has individual inter- intra-sample variation. Target fortification (TFO) a new regime aiming reduce such variations by individually measuring adding deficient macronutrients. Added TFO components...
Abstract Background Early-life antibiotic exposure is disproportionately high compared to the burden of culture-proven early-onset sepsis (CP-EOS). We assessed contribution culture-negative cases overall in first postnatal week. Methods conducted a retrospective analysis across eleven countries Europe, North America, and Australia. All late-preterm term infants born between 2014 2018 who received intravenous antibiotics during week were classified as treated for ≥5 days (CN ≥ 5d), <5 <...
Abstract Commercially available milk analysers were originally developed for use in the dairy industry, but they are now used to analyse macronutrient content of breast clinical studies and routine care premature or very low birthweight (VLBW) infants. Due different composition cow milk, these devices need be validated against reference methods before can daily routine. However, current require a sample volume 30–100 mL fat, protein lactose. It is not feasible obtain this research purposes,...