A5061518766- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Insect-Plant Interactions and Control
- Hemiptera Insect Studies
- Single-cell and spatial transcriptomics
- Insect and Pesticide Research
- Ferroptosis and cancer prognosis
- Computational Drug Discovery Methods
- Genetics, Bioinformatics, and Biomedical Research
- Molecular Biology Techniques and Applications
- Insect Pheromone Research and Control
- Neurobiology and Insect Physiology Research
- Environmental Toxicology and Ecotoxicology
- Wildlife-Road Interactions and Conservation
- Pharmacogenetics and Drug Metabolism
- Immune cells in cancer
- Insect and Arachnid Ecology and Behavior
- Insect Resistance and Genetics
- Biological Control of Invasive Species
- Insect Pest Control Strategies
- Advanced biosensing and bioanalysis techniques
- Genomics and Rare Diseases
Personalis (United States)
2015-2024
University of California, Riverside
2023-2024
New York University
2024
University of Washington
2001-2024
Seattle University
2024
Virginia Tech
2020-2024
Beltsville Agricultural Research Center
2022-2023
Agricultural Research Service
2022-2023
University of Delaware
2019
Stanford University
2013
Abstract One of the most important tasks modern bioinformatics is development computational tools that can be used to understand and treat human disease. To date, a variety methods have been explored algorithms for candidate gene prioritization are gaining in their usefulness. Here, we propose an algorithm detecting gene–disease associations based on protein–protein interaction network, known associations, protein sequence, functional information at molecular level. Our method, PhenoPred,...
Abstract Purpose: While immune checkpoint blockade (ICB) has become a pillar of cancer treatment, biomarkers that consistently predict patient response remain elusive due to the complex mechanisms driving tumors. We hypothesized multi-dimensional approach modeling both tumor and immune-related molecular would better ICB than simpler mutation-focused biomarkers, such as mutational burden (TMB). Experimental Design: Tumors from cohort patients with late-stage melanoma (n = 51) were profiled...
The brown marmorated stink bug, Halyomorpha halys (Stål), is a highly polyphagous species native to Asia that has become serious invasive agricultural and nuisance pest across North America Europe. Classical biological control host range evaluations have revealed egg parasitoid Trissolcus japonicus (Ashmead) be the primary candidate biocontrol agent for field release against H. halys. However, these only provide us with physiological of T. japonicus. Other demonstrated contact kairomones...
The rational discovery of behaviorally active odorants is impeded by a lack understanding on how the olfactory system generates percept or valence for volatile chemical. In previous studies we showed that chemical informatics could be used to model prediction ligands large repertoire odorant receptors in Drosophila (Boyle et al., 2013). However, it remained difficult predict behavioral volatiles since activities ensembles odor encode information, and little known complex information...
Insulin-associated signaling pathways are critical in the regulation of hepatic physiology. Recent inhibitor-based studies have implicated a mechanistic role for phosphatidylinositol 3′ kinase (PI3K) insulin-mediated suppression CYP2E1 mRNA levels hepatocytes. We investigated dose dependence this response and effects insulin extracellular matrix on PI3K expression using highly defined rat primary hepatocyte culture system. The inhibitors wortmannin LY294002 stimulated stress-activated...
Abstract In recent decades, the egg parasitoid Hadronotus pennsylvanicus (Ashmead) has gained substantial attention as an important natural enemy of pestiferous leaffooted bug species in genera Anasa Amyot and Serville Leptoglossus Guérin-Méneville. Throughout its native range North America, H. parasitizes eggs various vegetable orchard systems. The overreliance on broad-spectrum insecticides these systems demand for effective sustainable coreid pest management strategies have motivated...
Vittatalactone, the aggregation pheromone of striped cucumber beetle, Acalymma vittatum (F.) (Coleoptera: Chrysomelidae), is attractive to two species squash bugs (Hemiptera: Coreidae), bug Anasa tristis (DeGeer) and horned armigera (Say). In field trapping experiments in Maryland Virginia, clear sticky traps baited with 1 mg a synthetic 8-isomer mix vittatalactone captured ~9× more female A. both sexes armigera, whereas male were not significantly attracted, compared unbaited traps. showed...
Abstract Spotted cucumber beetle ( Diabrotica undecimpunctata howardi ; also known as southern corn rootworm) is a pest feeding on many crops, including cucurbits, (maize), peanuts, beans, and other crops wild plants in North America. On cucurbit where it co-occurs with striped Acalymma vittatum ), both are key pests that vector Erwinia tracheiphila, destructive pathogen causes bacterial wilt. Here we deployed synthetic vittatalactone, the male-produced aggregation pheromone of A. , lures...
The squash bug, Anasa tristis (De Geer) (Hemiptera: Coreidae), is a serious pest of cucurbit crops across the United States. Conventional growers commonly use broad-spectrum insecticides to manage bugs, however organic lack these effective chemical tools and must rely on alternative management strategies. Biological control A. largely understudied, specifically potential natural enemy, Hadronotus pennsylvanicus (Ashmead) (Hymenoptera: Scelionidae), as an augmentative biological agent. For...
The rational discovery of behaviorally active odorants is impeded by a lack understanding on how the olfactory system generates percept or valence for volatile chemical. In previous studies we showed that chemical informatics could be used to model prediction ligands large repertoire odorant receptors in Drosophila (Boyle et al., 2013). However, it remained difficult predict behavioral volatiles since activities ensembles odor encode information, and little known complex information...