A5069736026- Ubiquitin and proteasome pathways
- DNA Repair Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Fungal and yeast genetics research
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Cellular transport and secretion
- Mitochondrial Function and Pathology
- Glycosylation and Glycoproteins Research
- RNA and protein synthesis mechanisms
- Bacterial Genetics and Biotechnology
- Microtubule and mitosis dynamics
- DNA and Nucleic Acid Chemistry
- CRISPR and Genetic Engineering
- Nuclear Structure and Function
- Cell death mechanisms and regulation
- Peptidase Inhibition and Analysis
- Genetics and Neurodevelopmental Disorders
- 14-3-3 protein interactions
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Biofuel production and bioconversion
Max Planck Institute of Biochemistry
2012-2024
Ludwig-Maximilians-Universität München
2024
Max Planck Society
2005-2015
Osnabrück University
2014
Heidelberg University
1993-1999
German Cancer Research Center
1998
Friedrich Miescher Laboratory
1988-1998
DKFZ-ZMBH Alliance
1998
University of California, San Diego
1996
Universität Innsbruck
1994
Processing of integral membrane proteins in order to liberate active is exquisite cellular importance. Examples are the processing events that govern sterol regulation, Notch signaling, unfolded protein response, and APP fragmentation linked Alzheimer's disease. In these cases, thought be processed by regulated intramembrane proteolysis, involving site-specific, membrane-localized proteases. Here we show two homologous yeast transcription factors SPT23 MGA2 made as dormant ER/nuclear...
The OLE pathway of yeast regulates the level ER-bound enzyme Delta9-fatty acid desaturase OLE1, thereby controlling membrane fluidity. A central component this regulon is transcription factor SPT23, a homolog mammalian NF-kappaB. SPT23 synthesized as an inactive, ER membrane-anchored precursor that activated by regulated ubiquitin/proteasome-dependent processing (RUP). We now show dimerizes prior to and processed molecule, p90, retains its ubiquitin modification initially remains tethered...
Mutants in the gene CDC34 of yeast Saccharomyces cerevisiae are defective transition from G 1 to S phase cell cycle. This was cloned and shown encode a 295-residue protein that has substantial sequence similarity product RAD6 gene. The is required for variety cellular functions including DNA repair recently ubiquitin-conjugating enzyme. When produced Escherichia coli , catalyzed covalent attachment ubiquitin histones H2A H2B vitro, demonstrating another distinct member family enzymes. cycle...
Selective ubiquitin-dependent autophagy plays a pivotal role in the elimination of protein aggregates, assemblies, or organelles and counteracts cytotoxicity proteins linked to neurodegenerative diseases. Following substrate ubiquitylation, cargo is delivered autophagosomes involving adaptors like human p62 that bind ubiquitin autophagosomal ubiquitin-like Atg8/LC3; however, whether similar pathways exist lower eukaryotes remained unclear. Here, we identify by screen yeast new class...