A5035057357- Inhalation and Respiratory Drug Delivery
- Asthma and respiratory diseases
- Drug Solubulity and Delivery Systems
- Aerosol Filtration and Electrostatic Precipitation
- Pharmaceutical studies and practices
- Allergic Rhinitis and Sensitization
- Particle Dynamics in Fluid Flows
- Advanced Drug Delivery Systems
- Advanced Sensor Technologies Research
- Ion channel regulation and function
- Orthopedic Surgery and Rehabilitation
- Combustion and Detonation Processes
- Advanced Chemical Sensor Technologies
- Shoulder Injury and Treatment
- Refrigeration and Air Conditioning Technologies
- Statistical Methods in Clinical Trials
- Intravenous Infusion Technology and Safety
- Ion Transport and Channel Regulation
- Maritime Ports and Logistics
- Indoor Air Quality and Microbial Exposure
- Transport and Economic Policies
- Microencapsulation and Drying Processes
- Substance Abuse Treatment and Outcomes
- Eicosanoids and Hypertension Pharmacology
- Flow Measurement and Analysis
University of Groningen
2021
Medicon Village
2020
AstraZeneca (Sweden)
1998-2017
National Food Administration
2007
AstraZeneca (United Kingdom)
2007
University of Oslo
1979
A new cascade impactor has been designed specifically for pharmaceutical inhaler testing. This impactor, called the Next Generation Pharmaceutical Impactor (NGI), seven stages and is intended to operate at any inlet flow rate between 30 100 L/min. It spans a cut size (D50) range from 0.54-microm 11.7-microm aerodynamic diameter L/min 0.24 microm 6.12 The aerodynamics of follow established scientific principles, giving confident particle fractionation behavior over design range. NGI several...
Inhalation is a mainstay for treatment of asthma, and lung deposition can be seen as surrogate marker the ensuing clinical effects. Not only absolute deposition, but also its variability interest, it indicates range expected in an individual patient when prescribing drug day-to-day using it. A literature survey found 71 studies with relevant information on variability. Further characteristics studies, such if subjects were healthy or asthmatics, adults children, what device that was used,...
A validated method to predict lung deposition for inhaled medication from in vitro data is lacking spite of many attempts correlate and vivo outcomes. By using an vivo-like setup analyzing inhalers the same batches, both vivo, we wanted create a situation where information outcomes could be analyzed at time.Nine inhalation products containing either budesonide or AZD4818 were evaluated. These comprised two pressurized metered dose (pMDIs), pMDI plus spacer, four dry powder inhalers,...
Abstract Thirteen laboratories participated in an interlaboratory method performance (collaborative) study on a for the determination of arsenic, cadmium, mercury, and lead by inductively coupled plasma/mass spectrometry (ICP/MS) after pressure digestion including microwave heating technique. Prior to study, were able practice samples with defined element levels (pretrial test). The was tested total 7 foodstuffs: carrot puree, fish muscle, mushroom, graham flour, simulated diet, scampi,...
In comparison with pressurized metered dose inhalers (pMDIs), dry powder (DPIs) emit a semistable aerosol cloud and are inspiratory flow actuated driven. vitro studies show that different DPIs vary in their efficiency as delivery systems of fine drug particles (aerodynamic diameter < 5 μm). The may according to the force used generate aerosol. other DPIs, Turbuhaler® has been shown be an efficient particle generator at weak, moderate strong forces. Deposition using human throat casts have...
Abstract Background Phosphatidylethanol (PEth) is an abnormal phospholipid formed slowly in cell membranes by a transphosphatidylation reaction from phosphatidylcholine the presence of ethanol and catalyzed enzyme phospholipase D. PEth blood promising new marker abuse depending on high specificity sensitivity this marker. None biological markers used clinical routine at present time are sensitive specific enough for diagnosis alcohol abuse. The method analysis includes lipid extraction whole...
Magnetic resonance imaging (MRI) of the oropharyngeal region from 20 adult volunteers using four model inhalation devices (varying mouthpiece diameters, airflow resistances) and tidal breathing was carried out. Statistical analysis (convex hull method) selected 12 scans 80 data sets representing extremes all dimensions in population. Twelve physical mouth–throat models were made by stereolithography exact scan data. The aim to produce with varying span population, investigate if affected...
Exposure following oral inhalation depends on the deposition pattern of inhaled aerosol, extent and rate pulmonary absorption, as well systemic distribution clearance. For lipophilic compounds with low water solubility high permeability, absorption can be assumed dependent dissolution rate.A mechanistic model airway deposition, mucociliary clearance, dissolution, dissipation was applied to simulate exposure novel selective glucocorticoid receptor modulator, AZD5423, when dosed healthy...
Powder inhalers rely on the patient's inspiratory flow for delivery and aerosolization of medicament. Different offer different resistances to inspiration through device. The rate attained by a patient depends effort expended air resistance device; is thus device-dependent variable. A comparison between powder should therefore take their into account. An empirical relation peak device has been developed using results from healthy subjects verified limited extent data asthmatic patients. was...
ABSTRACT The multistage liquid impinger (MLI) is an impactor suitable for size-selective characterization and testing of pharmaceutical inhalation products, especially dry powder inhalers (DPIs). four-stage version the MLI, which was adopted by European Pharmacopoeia at 60 L/min, has been calibrated two different laboratories (Astra Draco AB, Sweden, AEA Technology, UK), reaching consistent results. MLI extended with additional impaction stage all stages have flow rates 30, 40, 50, 60, 80,...
Abstract The respiratory tract deposited fraction (DF) is the link between exposure and health effects of airborne particles. Here, we investigate how breathing pattern alterations at increasing physical activity affect DF in different regions compare adults children (5 10 years old). We performed a literature review on alteration tidal volume with minute ventilation used results to model size resolved (0.001–10 µm) DF, primarily using deposition models from NCRP Yeh Schum (1980), but also...
To investigate the impact of inhalation effort on peak inspiratory flow through Turbuhaler, 100 asthmatics having a wide range asthma severity (baseline forced expiratory volume in one second 28-127% predicted normal) were studied. Each patient inhaled four modifications empty Turbuhaler inhalers, using first "deep" and then "forceful deep" manoeuvre. Peak increased by an average 20% as compared to inhalation, with markedly higher increase for patients who had low deep inhalation. Virtually...
An empirical relation between the peak inspiratory flow through a device and resistance of has been developed using results from healthy subjects verified to limited extent data asthmatic patients. The can be used predict change in resulting resistance. Matching rates, representing equal force, may thus calculated for different inhalation devices. fine particle dose generated by variety commercial powder inhalers was tested in-vitro at rates representing, each device, weak, medium forceful...
In addition to aerosol particle size and mode of inhalation, the time-point dose delivery during inhalation may be an important factor governing intrapulmonary distribution aerosolized drug. To generate different deposition patterns a drug model aerosol, device with capability delivering small amounts technetium-99m-labeled lactose dry powder at pre-set time-points was developed. A single radioaerosol delivered after 20% (A) or 70% (B) vital capacity inhaled through device. Twelve healthy...
Background: Mechanistic computer models for calculation of total and regional deposition aerosols in the lungs are important tools predicting or understanding clinical studies facilitating development pharmaceutical inhalation products. Validation such must be indirect since generational vivo data lacking. Planar scintigraphy is probably most common method addressing lung humans. Scintigraphic regions interest (ROI) contain mixtures airway generations can therefore not directly compared to...