A5012816521- Aluminum toxicity and tolerance in plants and animals
- Radiopharmaceutical Chemistry and Applications
- Plant Stress Responses and Tolerance
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Plant Micronutrient Interactions and Effects
- Silicon Effects in Agriculture
- Nanoplatforms for cancer theranostics
- Magnesium in Health and Disease
- Metal complexes synthesis and properties
- Esophageal and GI Pathology
- Plant nutrient uptake and metabolism
- Neuroendocrine Tumor Research Advances
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Plant Genetic and Mutation Studies
- Drug Transport and Resistance Mechanisms
- Advanced MRI Techniques and Applications
- Cancer Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Clay minerals and soil interactions
- Gastric Cancer Management and Outcomes
- Medical Imaging and Pathology Studies
National Institutes for Quantum Science and Technology
2017-2024
Kawasaki Medical School Hospital
2019-2024
Kanagawa Cancer Center
2021-2024
Maebashi Institute of Technology
2019-2024
Kanagawa Prefectural Hospital Organization
2021-2024
Kin-ikyo Chuo Hospital
2024
Chiba University
2020-2023
Kisarazu Hospital
2023
Ehime University
2022
Nihon Medi-Physics (Japan)
1999-2020
An internal detoxification mechanism for Al was investigated in an Al-accumulating plant, hydrangea (Hydrangea macrophylla), focusing on forms present the cells. The leaves of contained as much 15.7 mmol kg-1 fresh weight, and more than two-thirds found cell sap. Using 27Al- nuclear magnetic resonance, dominant peak observed at a chemical shift 11 to 12 parts per million both intact extracted sap, which is good accordance with 1:1 Al-citrate complex. Purification sap by molecular sieve...
Journal Article Localization of absorbed aluminium in pea root and its binding to nucleic acids Get access H. Matsumoto, Matsumoto Department Agricultural Chemistry, Kyoto UniversityKyoto, 606, Japan Search for other works by this author on: Oxford Academic Google Scholar E. Hirasawa, Hirasawa Torikai, Torikai Takahashi Plant Cell Physiology, Volume 17, Issue 1, February 1976, Pages 127–137, https://doi.org/10.1093/oxfordjournals.pcp.a075252 Published: 01 1976 history Received: 29 September 1975
ABSTRACT In nutrient medium, aluminium (Al) accumulation in tobacco cells occurs only the presence of ferrous ion [Fe(II)]. The localization Al was examined to elucidate a mechanism accumulation. After digestion Al‐treated with cellulase and pectolyase together, resulting spheroplasts contained as much intact cells. However, cell walls isolated from also Comparison sugar contents polysaccharide components extracted chemically revealed that enzymes digested most cellulose hemicellulose, but...
Ascorbate content and the activities of ascorbate free-radical reductase (AFR-R) peroxidase (APX) were investigated in order to determine whether they are affected under Fe deficiency. Plasma membrane vesicles, cell wall cytosolic fractions isolated from roots cucumber (Cucumis sativus L.) plants grown absence or presence Fe. vesicles showed NADH-dependent reducing with Fe3+-citrate, ferricyanide AFR as electron acceptors. Only AFR-R activity was stimulated ca. 3-fold deficient plasma...
Although adrenal vein sampling is the standard method to distinguish unilateral from bilateral forms of primary aldosteronism, it an invasive and technically difficult procedure. 11C-metomidate (MTO)-positron emission tomography was reported as a potential replacement for sampling. However, MTO has low selectivity CYP11B2 over CYP11B1. This study aimed determine 18F-CDP2230, new imaging agent, CYP11B1 whether biodistribution profile 18F-CDP2230 favorable CYP11B2. The IC50 CDP2230 enzymatic...
Aluminum (Al) and ferrous iron [Fe(II)] are separately non-toxic to cultured tobacco cells in nutrient solution. However, Al Fe(II) together cause the peroxidation of membrane iipids, accumulation Fe, loss viability [Ono et al. (1995) Plant Cell Physiol. 36: 115]. We investigated cause-and-effect relationships these various responses. In exposed Fe(TT) or Fe(III)-EDTA, both ipids were similarly enhanced by AlCl3 a dose-dependent manner. During exposure AlCl3, became apparent rapidly...
• This study aims to clarify the effect of aluminum (Al) on surface potential and plasma membrane (PM) H+-ATPase activity, as linked exudation organic acid anions, using near-isogenic Al-tolerant (ET8) Al-sensitive (ES8) wheat (Triticum aestivum) lines. We examined (ζ potential) activity PM vesicles obtained from root tips (10 mm) region distal tip treated with Al either in vivo or vitro. After 4-h treatment (2.6 µm), H+ transport rate were decreased ζ was depolarized ES8 but not ET8. In 50...
Glioblastoma is the most aggressive malignant brain tumor in humans and difficult to cure using current treatment options. Hypoxic regions are frequently found glioblastoma, increased levels of hypoxia associated with poor clinical outcomes glioblastoma patients. Hypoxia plays important roles progression recurrence because drug delivery deficiencies induction hypoxia-inducible factor-1α cells, which lead prognosis. We focused on a promising hypoxia-targeted internal radiotherapy agent,...
Pancreatic cancer (PC) has a very poor prognosis. Surgery is the primary treatment for patients with resectable PC; however, local recurrence, hepatic metastasis, and peritoneal dissemination often occur even after extensive surgery. Adjuvant chemotherapy, typically gemcitabine, been used clinically but only modest survival benefit. To achieve better outcome, we investigated efficacy of <sup>64</sup>Cu-intraperitoneal radioimmunotherapy (ipRIT) <sup>64</sup>Cu-labeled antiepidermal growth...
Abstract This work is a study of the metabolic disorder due to ammonium toxicity in cucumber ( Cucumis sativus L. cv. suisei No. 2) leaves. The was cultured with 20 and 200 mg/l NH 3 ‐N for 5 days. In first half this experiment, plant leaves were photosynthesized hours distribution 14 C starch other fractions. incorporation into not only but also higher polymers suppressed by toxicity. On band, rate 80 % ethanol soluble fraction treatment ‐N. latter phosphate esters loaves analyzed column...
Purpose 64Cu-diacetyl-bis (N4-methylthiosemicarbazone) (64Cu-ATSM) is a promising theranostic agent that targets hypoxic regions in tumors related to malignant characteristics. Its diagnostic usefulness has been recognized clinical studies. Internal radiotherapy (IRT) with 64Cu-ATSM reportedly effective preclinical studies; however, for applications, improvements reduce radiation exposure non-target organs, particularly the liver, are required. We developed strategy doses critical organs...
To facilitate hypoxia imaging in a clinical setting, we developed 1-(2,2-dihydroxymethyl-3-[18F]-fluoropropyl)-2-nitroimidazole ([18F]DiFA) as new tracer that targets tumor with its lower lipophilicity and efficient radiosynthesis. Here, evaluated the radiation dosage, biodistribution, human safety, tolerability, early elimination after injection of [18F]DiFA healthy subjects, performed preliminary study patients malignant tumors comparison [18F]fluoromisonidazole ([18F]FMISO). The single...
Al inhibits root elongation at micromolar concentrations, but the mechanisms leading to this process are unknown. In these studies, Al-induced inhibition of cell was examined using hypocotyl okra (Abelmoschus esculentus Moench cv. Clemson Spineless) as an experimental model. One-h exposure (0.5 mM A1Cl3) in presence 10 μM auxin 0.5 CaCl2, pH 4.0 significantly inhibited auxin-induced segments. Elongation further suppressed with increasing concentrations up 1 mM. Treatment citrate for minutes...
// Yukie Yoshii 1 , Mitsuyoshi Yoshimoto 2 Hiroki Matsumoto 3 Hideaki Tashima Yuma Iwao Hiroyuki Takuwa Eiji Yoshida Hidekatsu Wakizaka Taiga Yamaya Ming-Rong Zhang Aya Sugyo Sayaka Hanadate Atsushi B. Tsuji and Tatsuya Higashi National Institute of Radiological Sciences, Institutes for Quantum Science Technology, Chiba, Japan Division Functional Imaging, Cancer Center Hospital East, Research Center, Nihon Medi-Physics Co., Ltd., Correspondence to: Yoshii, email: yoshii.yukie@qst.go.jp...
The chromosomal histone and non-histone proteins from embryo induced carrot cell cultures were analyzed by polyacrylamide gel electrophoresis compared with those non-induced cultures. 16 protein bands detected in the of control their patterns remained stable throughout culture period. Generally, similar found However, limited but distinct differences observed. A group low molecular weight was observed to be missing samples shortly after induction embryogenesis. In contrast, no changes histones
Abstract Pancreatic cancer (PC) has a poor prognosis owing to difficulties in the diagnosis of resectable PC at early stages. Several clinical studies have indicated that detection and surgery small (<1 cm) can significantly improve survival; however, imaging accurate resection remain challenging. Here, we report feasibility “immuno-OpenPET” as novel approach enabling not only but also image-guided surgery, using orthotopic xenograft mouse model. For immuno-OpenPET, utilized our original...
Abstract A series of linear-chain complexes molybdenum(II) acetate linked by bidentate bridging ligands, [Mo2(O2CCH3)4L]n (L = pyrazine (pyz), 4,4′ -bipyridine (4,4′-bpy), and 1,4-diazabicyclo[2.2.2]octane (dabco)), have been prepared, their crystal structures determined an X-ray diffraction method. It has shown that the relatively weak coordinations ligands at axial positions Mo2(O2CCH3)4 (Mo–N 2.619 (8)—2.658(6) Å) can effectively control arrangement dimer units to give chain with good...