A5072401403- Tuberculosis Research and Epidemiology
- Diagnosis and treatment of tuberculosis
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Diverse Scientific Research Studies
- Global Health and Epidemiology
- Mycobacterium research and diagnosis
- Thermal Regulation in Medicine
- Pneumocystis jirovecii pneumonia detection and treatment
- Vagus Nerve Stimulation Research
- Pneumonia and Respiratory Infections
- Pharmacological Effects of Natural Compounds
- Image Processing Techniques and Applications
- SARS-CoV-2 and COVID-19 Research
- Hematological disorders and diagnostics
- Tryptophan and brain disorders
- Dermatological and COVID-19 studies
- Biosimilars and Bioanalytical Methods
- Computational Drug Discovery Methods
- Pharmacovigilance and Adverse Drug Reactions
- Pleural and Pulmonary Diseases
Nicolae Testemițanu State University of Medicine and Pharmacy
2019-2023
Diagnostic methods of pulmonary tuberculosis (PTB) have a direct impact on the implementation prompt actions isolation source (TB) infection and initiation optimal treatment. The aim study was to establish clinical radiological peculiarities patients diagnosed with PTB through microbiological investigations in actual epidemiological context. It conducted case-control 172 PTB, new case, distributed into 2 groups, group 1 - 116 examination 56 methods. obtained results demonstrated that main...
The COVID-19 pandemic has surpassed any other health problem worldwide and disrupted the successes in tuberculosis (TB) control globally. aim of study was to assess clinical imaging characteristics patients with TB/COVID-19 co-infection. A retrospective on 80 co-infection (study group/SG) 113 TB (comparison group/CG) from Republic Moldova conducted. Clinical signs all both groups presented asthenia 100%, anorexia SG 100% vs. CG 82%, cough 93% 86%, fever 91% 3%, (p<0.05), low grade 9% 97%,...
Tuberculosis (TB) with multiple locations (TBML) is a severe form of TB, high mortality rate, particularly in the population recognized risk factors, including HIV infection and immunodeficiencies any origin. Aim was to analyze data from existing sources literature regarding TBML. The scientific publications PubMed Elsevier databases were studied. Review presented included on recent epidemiological situation, concepts pathogenesis mechanisms, clinical picture, imaging features, laboratory...
As a result of the analysis bibliographic sources, important information was elucidated regarding clinical manifestations and management patients with tuberculosis associated COVID-19 infection. The similarity these two diseases confirmed along importance investigations by presence “ground glass” opacities for diagnosis increased mortality among suffering from co-infection TB/COVID-19 argued cardiovascular endocrine comorbidities.
The data of 112 patients who died tuberculosis during 3 years (2018-2020) in the Municipal Hospital Phthisiopneumology Chisinau were studied. divided into two groups: 1 group — 73(65,9%) new cases pulmonary and 2 39(34,8%) re-treatment cases. It was found that 55(75,5%) 22(56,4%) from TB progression its complications. other diseases 18(24,7%) 17(45,6%) both groups, age between 41 more than 60 predominated, unemployed, singular status, people with severe forms (generalized, caseous...
The first case of COVID-19 in Moldova (MD) was diagnosed March 2020. Since then, 170186 cases were MD. aim to determine the epidemiological and clinical features patients Methodology: this prospective, descriptive study, analysed characteristics 145 admitted at Municipal Clinical Hospital Pneumophtisiology from 10th December 2020 till January 2021, which transformed centre. paired specimens throat nasal swabs collected all found positive for SARS-CoV-2 through RT-PCR assay. <b>Results:</b>...
Background: The surge demand and decreased availability of the health workers determined designation Clinical Municipal Hospital Phthisiopneumology (CMHP) into a hospital for case-management COVID-19 patients during period December 2020 – April 2021 treatment mild cases. aim study was to assess main peculiarities with through cross-sectional developed February-April in CMHP. Material methods: A cross-sectional, analytical prospective realized, which included 145 hospitalized CMHP 2021....
Introduction. Mortality among tuberculosis patients, both nationally and globally, has decreased significantly in the last 10 years, but current epidemiological situation allows to predict a new rise endemic state of disease due increase TB/HIV coinfection resistant tuberculosis. 
 Material methods. The patient’s reports were analyzed – cases, deaths progression registered Municipal Clinical Hospital Phthisiopneumology, Chisinau, 2 periods: 1st period 2001-2003 2nd 2018-2020. During...
Moldovan national policy allows 3 types of anti-TB treatment: 1. community observed delivered by the out-reacher; 2. DOT in hospitals; 3. Asynchronous video-supported (VST) with virtual management adverse drug effects. The aim was to assess impact VST on case-management and outcome TB. Was conducted a retrospective, selective, case-control study, 88 patients enrolled during 2020 y. Chisinau (R.Moldova). study group (SG) included 64 cases underwent continuation phase control (CG)-24 entirely...
Conventional laboratory assays proved various levels of sensibility in diagnosis TB pleural effusion (TPE), which is challenge early case-detection. The study aim was to establish the role criteria TPE. <b>Material and methods:</b> 69 adults diagnosed with TEP a single disease localization through clinical-radiological-laboratory tests during 2019-2022 Chisinau conducted. <b>Results:</b> male-female ratio 3,2/1, age between 18-24 yo established 5(7%), 25-44 38(55%), 45-64 16(23%) over...
In order to study the particularities of T lymphocyte content depending on indicators oxidative stress and antioxidant activity, in patients with pulmonary tuberculosis association COVID-19 coinfection, 42 were examined, which: a) baseline - 21 co-infection COVID-19, b) control group tuberculosis. At included study, there determined leukocyte formula, level CD3, CD4, CD8 lymphocytes, reaction as well activity. As a result, it was that at coinfection: particular, lymphocytes decreases...
The data of 164 patients who died from retreatment due to the progression tuberculosis in hospitals were subjected comparative analysis two periods: I period-120 (73.2%) years 2001-2003 (period introduction DOTS strategy) and II period - 44 (26.8%) 2018-2020. It was found that second compared more over age 55 died, HIV co-infection increased 6 times, therapeutic failure 7 times. Were infiltrative generalized forms decreased fibro-cavitary form. Over ½ deceased had resistant tuberculosis,...
The association of TB and diabetes mellitus (DM) counted 5% patients in 2017 the Republic Moldova (RM). aim was to identify impact DM associated risk factors (RF) on anti-TB treatment outcome. Was conducted a retrospective, selective, case-control study, which enrolled 252 patients registered with between 2016-2018 RM, distributed study group (SG) 93 diagnosed control (CG)-159 cases without glycemic disorders. Multivariable logistic regression estimated odds ratio (OR) 95% CI....
Patients with psychic pathologies (PP) have an increased risk for tuberculosis (TB) and constitute a group active screening in the Republic of Moldova (RM). The aim study was to identify factors (RF) for TB patients PP their treatment outcome. A selective, prospective case-control conducted, which included 212 TB patients, distributed (SG) 71 cases registered during 2015-2019 control (CG)-141 without mental disorders/PP duing 2019 RM. Multivariable logistic regression analysis...