The paper presents epidemiological process modeling, with a focus on tuberculosis utilizing multi-agent system. This study involves the development of an algorithm that harnesses potential artificial intelligence to create geospatial model highlights different pathways TB transmission. modeling itself is characterized by series key stages, including initialization city, calibration health parameters, simulation working day, propagation spread infection, evolution disease trajectories,...

Background. Glutathione (L-gamma-glutamyl-L-cysteinyl-glycine, GSH) and the enzymes of glutathione cycle play an important role in immune response against Mycobacterium tuberculosis infection. The purpose study was to assess main peculiarities differences thiol-disulfide metabolism patients with drug-susceptible multidrug-resistant (MDR-TB) developed on background diabetes mellitus (DM). Materials methods. A prospective case-control conducted between 2018 2022 included 173 TB divided into 3...

Tuberculosis (TB) remains one of the most pressing public health issues, especially in developing countries. The high incidence rate and spread multidrug-resistant strains “Mycobacterium tuberculosis” pose significant challenges to modern medicine. India is countries with highest TB burden, making optimization disease prediction methods crucial for effective implementation prevention treatment measures. application machine learning (ML) enables automation large-scale data analysis...

Ukraine is currently experiencing a new, ongoing tuberculosis offensive. Our study analyzes the impact of various socioeconomic and medical factors, including number specialized hospitals, fluoroscopic examinations population, healthcare workers, level alcohol drug abuse, others, on prevalence among different demographic groups in Ukraine. Artificial intelligence methods made it possible to identify key factors contributing growth or decline incidence. The results SHAP (SHapley Additive...

Hypertension and dyslipidemia represent two of the most relevant modifiable cardiovascular risk factors they often coexist. The aim research was to study lipid disorders essential arterial hypertension (EAH) depending on AGTR1 (rs5186) VDR (rs2228570) genes polymorphism.100 subjects with EAH target-organ damaging (2nd stage), moderate, high or very were involved in case-control study. Among them, 70,83% females 29,17% males, mean age 57,86 ± 7,81y.o. Control group consisted 60 practically...

The review contains an analysis of the latest research on molecular genetic aspects formation resistance in tuberculosis patients to avoid it during use modern treatment programs. Objective — assess situation with evolution Mycobacteria and stages drug development using materials from available databases. Materials methods. has been completed for period 2014 2024. next stage establishment a systemic topological metric computer results allowed us see most informative sections topic that are...

Objective — to assess the prospects for effects of interaction between COVID-19 and tuberculosis strategize risks infection in a coronavirus pandemic.Materials methods. Test access such full-text abstract databases was used: single information base package EBSCO; world's largest database scientometric platform Scopus; free search engine Google Scholar; MEDLINE with Full Text; Complete; Dyna Med Plus; EBSCO eBooks Clinical Collection; scientific publications project Web Know ledge companies...

La dynamique du niveau de l'aldostérone, la réorganisation tissu conjonctif et taux glucose comme marqueurs l'efficacité traitement tuberculose Objectif.L'étude visait à évaluer conjonctif, les d'aldostérone en tant que l'évolution favorable pulmonaire multirésistante.Matériels méthodes.L'étude a été réalisée sur 84 patients atteints multirésistante diagnostiquée pour première fois.Les d'aldostérone, d'hydroxyproline libres liés aux protéines ont mesurés chez tous patients.

Objective — systematic analysis of the results questionnaire and review available scientific databases to summarize achievements highlight complex TB issues in Ukraine.Materials methods. By communicating with doctors different specialties, on specializa­tion-courses, pre¬certification cycles thematic improvement specialty «phthisiology», «pulmonology», «general practice family medicine», «therapy», conducting their questionnaires, we conducted study priorities formulated questions problems...

OBJECTIVE. The purpose of our comprehensive analysis is to assess the prospects for effects interaction between coronavirus disease 2019 (COVID‑19) and tuberculosis (TB) strategize risks spreading TB infection in a pandemic. MATERIALS AND METHODS. Test access full-text abstract databases was used. RESULTS DISCUSSION. An available literature has shown that 3-month lockdown long 10-month recovery worldwide could lead an additional 6.3 million cases another 1.4 deaths 2020 2025. On average,...

To date, the COVID-19 pandemic has surpassed all other health issues around world. The interaction between and tuberculosis (TB), which remains leading cause of death from a single infectious disease in world, is important, as it can have serious consequences for both confirmed underdiagnosed TB patients worldwide, especially low- middle-income countries, where endemic services are poorly equipped. aim study to assess prospects epidemiology context SARS-CoV-2 Mycobacterium tuberculosis,...

Essential arterial hypertension (EAH) is a polygenic disease due to environmental, genetic, and epigenomic factors. The study aimed establish the association of single nucleotide polymorphism (SNP) AGTR1 (rs5186) VDR (rs2228570) genes with blood pressure (BP) elevation in EAH patients. 100 subjects hypertensive-mediated organ damaging (2nd stage), moderate, high, or very high cardiovascular risk were recruited into case-control study. There 70.83% females 29.17% males, mean age 57.86±7.81...

The aim of the study: to determine prognostic impact polymorphism glutathione-S-transferase genes on efficiency treatment comorbidity diabetes mellitus and multidrug-resistant tuberculosis. Subject. We have examined 100 patients with tuberculosis (MDR-TB) mellitus. <b>Methods:</b> Polymorphism GSTM1 areas were isolated using complex multi PCR for M. Arana et all (1996). <b>Results:</b> Patients pulmonary MDR-TB who are carriers wild alleles (GSTM1 + / GSTT1 +) experienced bacterioexcretion...

BACKGROUND. One of the important reasons treatment falures tuberculosis (TB) is insufficient serum concentration anti-TB drugs in blood patients which contributes to development drug resistance strains M. and formation multidrug-resistant (MDR-TB), as well a significant number forms resistant isoniazid. THE PURPOSE study was assess role determining type acetylator according N-acetyltransferase 2 genotype influence M1 class glutathione-S-transferase gene on efficacy for TB individual dose...

Background. A statistical analysis published in the WHO report for 2019 showed that almost 10.0 million people (about 9.0-11.1 million) fell ill with tuberculosis (TB) worldwide 2018. The purpose of a systematic examination and is to summarize achievements study complex issues overcoming world at present stage, need more attention, scrutiny, or change approach addressing specific challenges towards achieving strategic global goals eradicating this infection. Materials methods. We used test...

Objective: Objective of the study is establish prevalence and influence diabetes on course pulmonary tuberculosis. Design method: Our based an analysis statistical data obtained from a retrospective 762 case histories cases MDR-TB in register tuberculosis patients different regions Ukraine Grodno region Republic Belarus for 2016-2020. Results: The showed that included study, mellitus was detected 28 (31.2%) simultaneously with tuberculosis; 60 (68.8%) developed before background...

INTRODUCTION: Therapeutic drug monitoring (TDM) could improve TB treatment outcomes by avoiding toxicity or underdosing. In this study, we describe the patient burden in three centres Romania and Ukraine with a TDM indication, as per current guidelines, order to estimate feasibility of implementing TDM.METHODS: A retrospective multi-centre study was conducted at Iasi Lung Hospital (Iasi, Romania), Bucharest Marius Nasta Institute (Bucharest, Romania) Chernivtsi Centre (Chernivtsi, Ukraine)...

Historically, human migration has had a major impact on the spread of tuberculosis (TB). Ukraine and EU in general are experiencing largest crisis since Second World War. As 11/15/2022, 7.6 million Ukrainians remain abroad due to Russo-Ukrainian war. According UN data, there almost 5 Ukrainian refugees Europe. By end 2022, Poland granted status temporary protection 1.5 migrants, Germany more than 1 Czech Republic approximately 450.000. More 100.000 registered Italy, Spain, Great Britain,...

HIV infection induces severe immunosuppression, considered the major risk factor for tuberculosis (TB). Objective — to evaluate clinical characteristics of patients with TB-HIV co-infection based on level immune deficiency establish recommendations improving case management. Materials and methods. A prospective, selective study included 86 TB patients, divided into group 38 cases evolved acquired immunodeficiency syndrome (AIDS), established a CD4+ ≤ 200/μL control 48 having ≥ 200/μL....

BACKGROUND. The paper presents epidemiological process modeling, with a focus on tuberculosis utilizing multi-agent system. MATERIALS AND METHODS. This study involves the development of an algorithm that uses potential artificial intelligence to create geospatial model highlights different routes transmission. simulation itself is characterized by number key stages, including initialization city, calibration health parameters, working day, spread infection, evolution disease trajectories,...