A5010483792- Hormonal Regulation and Hypertension
- Human Health and Disease
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Healthcare Systems and Public Health
- Nutrition, Genetics, and Disease
- Cardiac, Anesthesia and Surgical Outcomes
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Appendicitis Diagnosis and Management
- Hernia repair and management
- Neurological Disorders and Treatments
- Sepsis Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Cardiovascular Disease and Adiposity
- Eicosanoids and Hypertension Pharmacology
- Gastrointestinal disorders and treatments
- Hemodynamic Monitoring and Therapy
- Biomarkers in Disease Mechanisms
- Pancreatitis Pathology and Treatment
- Inflammasome and immune disorders
- COVID-19 and healthcare impacts
- Atherosclerosis and Cardiovascular Diseases
- Gastric Cancer Management and Outcomes
- Congenital Diaphragmatic Hernia Studies
Bukovinian State Medical University
2015-2024
Fluor (United States)
2024
Yuriy Fedkovych Chernivtsi National University
2022
ORCID
2020
Ukrainian Medical Stomatological Academy
2019
Objective. The aim of the present study was to clarify endothelial function biomarkers and carotid "intima media" thickness (IMT) changes in relation GNB3 (rs5443) NOS3 (rs2070744) genes polymorphism essential arterial hypertension (EAH). Methods. One-hundred EAH patients (48 - control) participated case-control study. Soluble vascular cell adhesion molecule (sVCAM-1), total NO metabolites (NO2-+NO3-), transcriptional activity gene, endothelium-dependent flow-mediated dilation brachial...
Acute mesenteric ischaemia (AMI) is a condition with high mortality. This survey assesses current attitudes and practices to manage AMI worldwide.A questionnaire about the of diagnosing managing AMI, endorsed by several specialist societies, was sent different medical specialists hospitals worldwide. Data from individual health care professionals teams were collected.We collected 493 forms 71 countries 94 team 34 countries. Almost half respondents surgeons, most responding (70%) led...
The mechanisms orchestrating the balance between nitric oxide and endothelium-derived contracting factors, genetic predisposition to endothelial dysfunction in hypertensive patients remain be determined. One-hundred participated case-control study clarify risk of carotid "intima media" thickness (IMT) changes depending on NOS3 (rs2070744) GNB3 (rs5443) genes' polymorphisms. It is found that presence gene's С-allele significantly elevates atherosclerotic plaques arteries (OR95%CI: 1.24-11.20;...
Immunocompromised patients with acute diverticulitis are at increased risk of morbidity and mortality. The aim this study was to compare clinical presentations, types treatment, outcomes between immunocompromised immunocompetent diverticulitis.We compared the data extracted from Web-based International Registry Emergency Surgery Trauma (WIRES-T) January 2018 December 2021. First, two groups were identified: medical therapy (A) surgical (B). Each group divided into three subgroups:...
Abstract Objective. The cytochrome 11B2 aldosterone synthase gene ( CYP11B2 ) that links to enzyme synthesis changes and blood pressure regulation is of particular interest among the renin-angiotensin-aldosterone system encoding genes. Methods. One-hundred hypertensive patients with target-organ damaging (2nd stage), moderate, high or very cardiovascular risk were involved in case-control study. Mean age was 59.87±8.02 years. Diabetes Mellitus type 2 (DM2) 28 persons. Chronic kidney disease...
The study aim was to analyse the frequency of polymorphic variants angiotensinogen gene polymorphism (AGT 704T>C, rs699) in essential arterial hypertension (EAH) patients.Seventy-two individuals with EAH and hypertension‑mediated organ damage (stage 2), moderate, high or very cardiovascular risks were involved case-control study. Among them, 70.84 % (51) females 29.16 (21) males; mean age 59.87±7.98 y. control group consisted fifty practically healthy at relevant (49.13±6.28 y) sex...
The frequency of purulent-septic complications in diseases the genitourinary system remains quite high, without a noticeable tendency to decrease, which negatively affects results their treatment. number and relapses especially patients working age. aim study is research levels adaptive stress cellular reactivity body with acute purulent-inflammatory kidneys paranephral tissue. Material methods. involved 145 tissue (APIDKPT). average age was 45.20±12.81 years. level assessed by indices,...
The purpose of this study was to investigate polymorphic variants the genes FGB (rs1800790), NOS3 (rs2070744) and TMPRSS2 (rs12329760) in patients with coronavirus infection determine their role development clinical forms COVID-19 on background antiviral therapy. Real-time polymerase chain reaction (RT-PCR) used genotype polymorphism selected genes. GS-5734 (Remdesivir) prescribed as basic drug. Binary logistic regression confirmed a low probability developing carriers mutational A-allele...
Summary. Introduction. As is known, sepsis among the top ten leading causes of death in world, and mortality rate high remains at 9-32%. According to modern concepts, an excessive life-threatening reaction body infection, which leads disruption many organ systems characterized by multiple failure. The aim study. research assess prognostic diagnostic value various clinical laboratory parameters order substantiate a complex for patients with abdominal (AS). Materials methods. study involved...
Summary. Introduction. Hemorrhoids are one of the most common diseases rectoanal area, in particular, USA alone, about 2.2 million cases this disease recorded annually, significantly affecting quality life patients and is considered leading cause non-fatal bleeding from distal gastrointestinal tract. In addition, hemorrhoids significant discomfort impaired work capacity. According to literature, number people suffering world reaches 50-85%, affects any gender at age. The aim study. analyze...
The purpose of this study was to investigate polymorphic variants the genes FGB (rs1800790), NOS3 (rs2070744) and TMPRSS2 (rs12329760) in patients with SARS-CoV-2 determine their role COVID-19 severity course against background antiviral therapy. Real-time polymerase chain reaction (RT-PCR) used genotype polymorphism selected genes. GS-5734 (remdesivir) prescribed as basic drug. Binary logistic regression confirmed a low probability developing carriers A-allele gene. highest moderate severe...
Renin-angiotensin aldosterone system (RAAS) holds a crucial role in blood pressure regulation. Aldosterone is encoded by the cytochrome 11B2 synthase gene (CYP11B2). The study aim was to analyze association of Chronic Kidney Disease (CKD) with allelic polymorphism CYP11B2 at position -344 (-344C/T) promoter patients essential arterial hypertension (EAH). 72 subjects EAH and target-organ damaging (2nd stage), moderate, high or very cardiovascular risk were involved case-control study. Among...
Objective: Obesity is a major risk factor of essential arterial hypertension (EAH). Therefore, we studied the dependence 25-OH vitamin D (VitD), parathyroid hormone (PTH), Adiponectine, Leptin and ionized calcium blood values on degrees in EAH patients. Design method: Study involves 100 patients with hypertensive-mediated organ damage (moderate-very-high cardiovascular risks, aged 45-65). was determined by body mass index (BMI) >30 kg/m 2 : 1st obesity degree – 30-34.9 , 2nd 35-39.9 3rd...
As a result of determining the reactive response neutrophils in 34 patients with acute bronchitis we found out that disease is accompanied by an increase shift index, reactivity index and leukocytes index. Increasing secretory activity respect interleukins 6 8, tumor necrosis factor alpha interferon occurs inhibition bactericidal neutrophils.
The aim: To clarify the efficacy of probiotics use as a preventive measure for post-antibiotic treatment in acute peritonitis and increase staff awareness related to antibiotic probiotic use. Materials methods: study design included determination proper strain combination clinical application strains. control group consisted 63 (48.46%) patients who underwent traditional multimodal 67 (51.54%) individuals, with inclusion different antibiotic/probiotic combinations. Results: Prior...
The aim – to ascertain the etiological role of various taxonomic groups autochthonousand allochthonous microorganisms in origin acute purulent- inflammatory diseasesof urinary system as a prerequisite abdominal sepsis.Materials and methods. study covers 145 patients with inflammatorydiseases system. When studying microbiota system,standard microbiological methods were used, number colony- forming units(CFU) was counted, determining population level each species or group themicroorganisms,...
Chronic non‑healing wounds (CNHW) are very common and often incorrectly treated, the morbidity associated costs of chronic management highlight need to implement wound prevention treatment concepts. Objective — evaluate possibility different metal nanooxide polymer nanofilms use for CNHW’ local treatment. Materials methods. The study design is based on evaluation various types dressing materials considering their option in CNHW Samples biodegradable films (with an optimal composition...
Abstract Objective. The aim of this study was to evaluate the association α-adducin-1 gene ( ADD1 ) (Gly460Trp [rs4961]) polymorphism and its expression in with renal dysfunction sodium sensitivity hypertensive patients western Ukrainian population. Methods. One-hundred essential arterial hypertension (EAH) hypertensive-mediated target organ damage (stage 2), moderate, high, very high cardiovascular risk were enrolled case-control study. Sixty healthy individuals assigned as controls. Sodium...
Objective To establish the association of SEPP1 gene’s (rs7579) polymorphism with enzymatic, metabolic and hormonal activity in patients chronic pancreatitis (CP) primary hypothyroidism. Materials methods Eighty CP (40 comorbid hypothyroidism) 30 healthy controls participated case-control study. Pancreatic enzymes, Selenoprotein P, NO metabolites (NO2 -+NO3 -), glucose, total cholesterol (TC), triglycerides (TG) low/high density lipoprotein (LDL-, HDL-C), Atherogenicity Index (AI),...
Kidneys are sensitive to damage by pathogenic factors of dysbiotic syndrome, among which lipopolysaccharide is the main one. However, influence syndrome on formation nephropathy has not been studied enough. The aim study determine effect kidneys rats an experimental was modeled using antibiotic lincomycin in combination with administration epinephrine. Material and methods. Experimental (systemic dysbiosis) reproduced 21 Wistar (female, 11 months old, average weight 310±25 g) adrenaline...
The vascular endothelium is one of the earliest damage-targeted hypertensive-mediated organs. study aims to analyze link metabolic disorders with endothelial dysfunction (ED) and NOS3 (rs2070744) GNB3 (rs5443) genes polymorphism in essential arterial hypertension (EAH). One hundred EAH patients (48 – healthy control) participated case-control study. Creatinine, glucose, triglycerides, total cholesterol (TC), low/high-density lipoproteins values (LDL-C, HDL-C), Atherogenicity Index (AI),...