A5008912825- Hormonal Regulation and Hypertension
- Human Health and Disease
- Blood Pressure and Hypertension Studies
- Nutrition, Genetics, and Disease
- Pancreatitis Pathology and Treatment
- Healthcare Systems and Public Health
- Sodium Intake and Health
- Technology and Human Factors in Education and Health
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Lipoproteins and Cardiovascular Health
- Biomarkers in Disease Mechanisms
- Selenium in Biological Systems
- COVID-19 and healthcare impacts
- Diet, Metabolism, and Disease
- Vitamin D Research Studies
- Appendicitis Diagnosis and Management
- Nutrition and Health Studies
- Cardiovascular Function and Risk Factors
- COVID-19 Clinical Research Studies
- Inflammatory Bowel Disease
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Renin-Angiotensin System Studies
- Cardiovascular Disease and Adiposity
Yuriy Fedkovych Chernivtsi National University
2025
Bukovinian State Medical University
2019-2023
Ministry of Health
2020
Objective. The aim of the present study was to clarify endothelial function biomarkers and carotid "intima media" thickness (IMT) changes in relation GNB3 (rs5443) NOS3 (rs2070744) genes polymorphism essential arterial hypertension (EAH). Methods. One-hundred EAH patients (48 - control) participated case-control study. Soluble vascular cell adhesion molecule (sVCAM-1), total NO metabolites (NO2-+NO3-), transcriptional activity gene, endothelium-dependent flow-mediated dilation brachial...
The mechanisms orchestrating the balance between nitric oxide and endothelium-derived contracting factors, genetic predisposition to endothelial dysfunction in hypertensive patients remain be determined. One-hundred participated case-control study clarify risk of carotid "intima media" thickness (IMT) changes depending on NOS3 (rs2070744) GNB3 (rs5443) genes' polymorphisms. It is found that presence gene's С-allele significantly elevates atherosclerotic plaques arteries (OR95%CI: 1.24-11.20;...
Abstract Objective. The cytochrome 11B2 aldosterone synthase gene ( CYP11B2 ) that links to enzyme synthesis changes and blood pressure regulation is of particular interest among the renin-angiotensin-aldosterone system encoding genes. Methods. One-hundred hypertensive patients with target-organ damaging (2nd stage), moderate, high or very cardiovascular risk were involved in case-control study. Mean age was 59.87±8.02 years. Diabetes Mellitus type 2 (DM2) 28 persons. Chronic kidney disease...
The study aim was to analyse the frequency of polymorphic variants angiotensinogen gene polymorphism (AGT 704T>C, rs699) in essential arterial hypertension (EAH) patients.Seventy-two individuals with EAH and hypertension‑mediated organ damage (stage 2), moderate, high or very cardiovascular risks were involved case-control study. Among them, 70.84 % (51) females 29.16 (21) males; mean age 59.87±7.98 y. control group consisted fifty practically healthy at relevant (49.13±6.28 y) sex...
This paper explores the integration of generative AI tools, particularly ChatGPT, into second language training programs. With rapid advancements in artificial intelligence, these tools offer innovative opportunities for enhancing learning by providing draft translations, clarifying vocabulary and grammar, delivering real-time feedback on production. The study examines potential AI-assisted to improve efficiency, linguistic accuracy, cultural adaptability both academic professional settings....
Renin-angiotensin aldosterone system (RAAS) holds a crucial role in blood pressure regulation. Aldosterone is encoded by the cytochrome 11B2 synthase gene (CYP11B2). The study aim was to analyze association of Chronic Kidney Disease (CKD) with allelic polymorphism CYP11B2 at position -344 (-344C/T) promoter patients essential arterial hypertension (EAH). 72 subjects EAH and target-organ damaging (2nd stage), moderate, high or very cardiovascular risk were involved case-control study. Among...
Objective To establish the association of SEPP1 gene’s (rs7579) polymorphism with enzymatic, metabolic and hormonal activity in patients chronic pancreatitis (CP) primary hypothyroidism. Materials methods Eighty CP (40 comorbid hypothyroidism) 30 healthy controls participated case-control study. Pancreatic enzymes, Selenoprotein P, NO metabolites (NO2 -+NO3 -), glucose, total cholesterol (TC), triglycerides (TG) low/high density lipoprotein (LDL-, HDL-C), Atherogenicity Index (AI),...
The vascular endothelium is one of the earliest damage-targeted hypertensive-mediated organs. study aims to analyze link metabolic disorders with endothelial dysfunction (ED) and NOS3 (rs2070744) GNB3 (rs5443) genes polymorphism in essential arterial hypertension (EAH). One hundred EAH patients (48 – healthy control) participated case-control study. Creatinine, glucose, triglycerides, total cholesterol (TC), low/high-density lipoproteins values (LDL-C, HDL-C), Atherogenicity Index (AI),...
Background: Left ventricular hypertrophy (LVH) is not only complications or the damaged appearance of target organ patients with essential arterial hypertension (EAH), but at same time, it also a prognostic factor. Aim: The aim to evaluate echocardiographic (Echo-CG) changes in EAH depending on genes AGT (rs4762), GNB3 (rs5443), and some humoral markers. Methods: A total 100 were recruited for this study. (rs4762) (rs5443) genotyping performed by Real-Time PCR. All individuals tested serum...
BACKGROUND: Cardiovascular (CV) diseases are the most spread cause of mortality in world. Essential arterial hypertension (EAH), as a major risk factor for development CV diseases, is multifactorial disease involving environmental and genetic factors together with risk-conferring behaviors. AIM: The purpose this study was to analyze lipid metabolism changes patients EAH depending on Vitamin D receptor (VDR rs2228570 (aka rs10735810)) angiotensinogen (AGT rs699) genes polymorphism. MATERIALS...
Objective: Metabolic changes and obesity play important roles in arterial hypertension pathogenesis progression. Whereas hepatic steatosis (HS) AH have multiple common mechanisms of development involving metabolic immune changes, the aim study was to investigate influence Pro12Ala polymorphism PPAR-↖2 gene I/D ACE on profile cytokines obese patients with HS AH. Design method: Study involved 154 (87 males, 67 females, age 50.06±7.34). Duration 1-5 years, 3-21 years. disorders were defined...
One of the most important reasons health status deterioration among child population is infraction diet structure and decrease its Quality. The purpose research to study analyze Quantitative Qualitative composition daily dietary intakes preschool children attending children's educational establishments, followed by a hygienic assessment their balance with main nutrients. intake has been assessed comparing received data state normative documents international recommendations. Analysis...
A prospective study covered 102 children aged from 6 to 18 years (on average 11,5±3,15 years) with hearing impairment, nincluding 68 sensorineural damage, 34 – conductive. The role of concomitant chronic otorhinolaryngologic diseases, burdened family history as risk factors for or conductive deafness / loss in were investigated. tonsillitis increased the by 3,46 times older than 12 years, and otitis, tubootitis likelihood 10.6 6.8 all age groups. relative developing impairments increases...
Qualitative and quantitative composition of the daily nutrition ration children at preschool institutions Chernivtsi was investigated analyzed. Hygienic evaluation fats polyunsaturated fatty acids constituent provided. Analysis children’s diets in 9 showed that their food variable, order intervals between meals were kept, as well sequence taking dishes distribution energy value. In insufficient content products are sources fats vegetable animal origin (meat, fish, eggs, oil, milk, dairy...
Qualitative and quantitative composition of the daily nutrition ration children at preschool institutions Chernivtsi was investigated analyzed. Hygienic evaluation carbohydrate constituent provided. Analysis children’s diets in 9 showed that percentage content simple carbohydrates diet twice more than recommended norm. The dietary fiber all lower one. main reasons disbalance food are increase consumption white bread, macaroni confectionery products, absence rye deficiency fresh fruits...
Objective: Endothelial dysfunction (ED) is an initial step to vascular insufficiency, atherosclerosis. The study aimed clarify the risk of ED and carotid arteries (CA) intima media thickness (IMT) changes depending on guanine-nucleotide-binding-protein-beta-3 (GNB3, rs5443) endothelial-nitric-oxide-synthase (NOS3, rs2070744) genes’ polymorphisms in essential arterial hypertension (EAH). Design method: One-hundred EAH patients with target-organ damage, moderate/high/very high cardiovascular...
Objective: Obesity is a major risk factor of essential arterial hypertension (EAH) because neuro-hormonal, sympathoadrenal and renin-angiotensin-aldosterone system activation, as well endothelial dysfunction systemic low grade inflammation. However, genetic mechanisms obesity development in EAH patients remained unclear. Therefore, we studied the guanine nucleotide-binding protein-↓3 (GNB3, rs5443) nitric oxide synthase (NOS3, rs2070744) genes’ polymorphisms possible harbingers particularly...
Objective: Metabolic violations, obesity and other related comorbidities are obvious in arterial hypertension. It is known that Hepatic Steatosis (HS) Arterial hypertension (AH) has to some extend common pathogenesis realized through metabolic immune mechanisms involving vascular digestive system injury, forming Gut-Liver axis, which remain mostly untouched recent studies. We aimed on evaluating the endothelial function mesenteric vessels remodeling depending I/D polymorphism of...
Objective: to evaluate the gene-gene interaction, assess risks and develop some approximation models of hearing loss / deafness occurrence in children, depending on genes polymorphism gab junction B2 (GJB2, rs80338939), interleukin-4 (IL-4, rs 2243250) other risk factors. Materials methods: Study included 102 children with impairment: 68 sensorineural (SNHL) 34 conductive (CHL), among them 36 (35.29%) girls 66 (64.71%) boys. The patients' age vary from 8 18 yo (on average 13.90±3.11 yo)....
Поєднання есенціальної артеріальної гіпертензії (ЕАГ) та цукрового діабету – провідна незалежна причина ураження нирок, на їх частку припадає 63 % усіх випадків хронічної хвороби нирок (ХХН).
 Мета оцінити кореляції розробити моделі апроксимації появи ХХН у хворих ЕАГ з урахуванням алельного стану гена цитохрому 11b2 альдостерон-синтетази (CYP11B2, rs1799998).
 Матеріал і методи. Скринінг пройшли 100 ЕАГ, яким виконали комплекс клінічно-лабораторних обстежень із наступним...