A5030167667- Nutrition, Genetics, and Disease
- Hormonal Regulation and Hypertension
- Vitamin D Research Studies
- Blood Pressure and Hypertension Studies
- Cancer, Lipids, and Metabolism
- Biomarkers in Disease Mechanisms
- Birth, Development, and Health
- Eicosanoids and Hypertension Pharmacology
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Genetic Associations and Epidemiology
- Regulation of Appetite and Obesity
- Sodium Intake and Health
- Health and Lifestyle Studies
- Lipoproteins and Cardiovascular Health
- Human Health and Disease
- Pulmonary Hypertension Research and Treatments
- Digestive system and related health
- Cytokine Signaling Pathways and Interactions
- Atherosclerosis and Cardiovascular Diseases
- Nutritional Studies and Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
Bukovinian State Medical University
2020-2024
The study aim was to analyse the frequency of polymorphic variants angiotensinogen gene polymorphism (AGT 704T>C, rs699) in essential arterial hypertension (EAH) patients.Seventy-two individuals with EAH and hypertension‑mediated organ damage (stage 2), moderate, high or very cardiovascular risks were involved case-control study. Among them, 70.84 % (51) females 29.16 (21) males; mean age 59.87±7.98 y. control group consisted fifty practically healthy at relevant (49.13±6.28 y) sex...
Renin-angiotensin aldosterone system (RAAS) holds a crucial role in blood pressure regulation. Aldosterone is encoded by the cytochrome 11B2 synthase gene (CYP11B2). The study aim was to analyze association of Chronic Kidney Disease (CKD) with allelic polymorphism CYP11B2 at position -344 (-344C/T) promoter patients essential arterial hypertension (EAH). 72 subjects EAH and target-organ damaging (2nd stage), moderate, high or very cardiovascular risk were involved case-control study. Among...
Hypertension and dyslipidemia represent two of the most relevant modifiable cardiovascular risk factors they often coexist. The aim research was to study lipid disorders essential arterial hypertension (EAH) depending on AGTR1 (rs5186) VDR (rs2228570) genes polymorphism.100 subjects with EAH target-organ damaging (2nd stage), moderate, high or very were involved in case-control study. Among them, 70,83% females 29,17% males, mean age 57,86 ± 7,81y.o. Control group consisted 60 practically...
Objective: Obesity is a major risk factor of essential arterial hypertension (EAH). Therefore, we studied the dependence 25-OH vitamin D (VitD), parathyroid hormone (PTH), Adiponectine, Leptin and ionized calcium blood values on degrees in EAH patients. Design method: Study involves 100 patients with hypertensive-mediated organ damage (moderate-very-high cardiovascular risks, aged 45-65). was determined by body mass index (BMI) >30 kg/m 2 : 1st obesity degree – 30-34.9 , 2nd 35-39.9 3rd...
Background: Left ventricular hypertrophy (LVH) is not only complications or the damaged appearance of target organ patients with essential arterial hypertension (EAH), but at same time, it also a prognostic factor. Aim: The aim to evaluate echocardiographic (Echo-CG) changes in EAH depending on genes AGT (rs4762), GNB3 (rs5443), and some humoral markers. Methods: A total 100 were recruited for this study. (rs4762) (rs5443) genotyping performed by Real-Time PCR. All individuals tested serum...
BACKGROUND: Cardiovascular (CV) diseases are the most spread cause of mortality in world. Essential arterial hypertension (EAH), as a major risk factor for development CV diseases, is multifactorial disease involving environmental and genetic factors together with risk-conferring behaviors. AIM: The purpose this study was to analyze lipid metabolism changes patients EAH depending on Vitamin D receptor (VDR rs2228570 (aka rs10735810)) angiotensinogen (AGT rs699) genes polymorphism. MATERIALS...
Objective: To evaluate the role of polymorphism AGT genes (rs4762) and GNB3 (rs5443) in development essential arterial hypertension separately by combining their polymorphic variants. Design method: The case-control study involved 100 patients with EAH stage II, 1-3 degrees blood pressure (BP), high very cardiovascular risk. Among there were 21% (21) men, 79% (79) women. mean age was 59.86±6.22y.o. control group consisted 60 almost healthy individuals, relevant (49.13±6.28y.o.) gender...
Objective: Metabolic changes and obesity play important roles in arterial hypertension pathogenesis progression. Whereas hepatic steatosis (HS) AH have multiple common mechanisms of development involving metabolic immune changes, the aim study was to investigate influence Pro12Ala polymorphism PPAR-↖2 gene I/D ACE on profile cytokines obese patients with HS AH. Design method: Study involved 154 (87 males, 67 females, age 50.06±7.34). Duration 1-5 years, 3-21 years. disorders were defined...
Objective: The aim of the study was to analyze correlations between body mass index (BMI) and clinical laboratory parameters in patients with essential hypertension (EH) depending on angiotensinogen gene (AGT, rs699) polymorphism. Design method: case-control involved 72 stage II EH, 1–3 degrees blood pressure (BP) elevation, high very cardiovascular risk (CVR) (29.16% men, 70.84% women). mean age 59.87±7.98 yo. control group consisted 48 healthy individuals comparable gender. Polymorphism...
Objective: Obesity is a major risk factor of essential arterial hypertension (EAH) because neuro-hormonal, sympathoadrenal and renin-angiotensin-aldosterone system activation, as well endothelial dysfunction systemic low grade inflammation. However, genetic mechanisms obesity development in EAH patients remained unclear. Therefore, we studied the guanine nucleotide-binding protein-↓3 (GNB3, rs5443) nitric oxide synthase (NOS3, rs2070744) genes’ polymorphisms possible harbingers particularly...
Objective: The aim of the study was to evaluate changes in clinical and laboratory parameters analyze linkage between blood pressure (BP), body mass index (BMI) anthropometric, metabolic, hormonal patients with essential arterial hypertension (EAH). Design method: 100 subjects EAH target-organ damaging (2nd stage), moderate, high, very high cardiovascular risk were involved case-control study. There 70.84% females, 29.16% males, mean age 57.86±7,81 yo. control group consisted 60 healthy...
Objective: The aim of the study was to analyze lipids` changes in patients with essential arterial hypertension (EAH) depending on vitamin D receptor gene (VDR, rs2228570) polymorphism. Design and method: involved 100 suffering from EAH target-organ damaging, moderate, high, or very high cardiovascular risk. Among them were 79.0% (79) women 21.0% (21) men, average age 59.87±8.02 yo. control group 60 practically healthy persons, matched by gender distribution. All enrolled/screened signed...
Objective: To analyze the association of hypertrophic geometric models left ventricle (LV) with changes in clinical, anthropometric and metabolic-hormonal parameters mineral metabolism data patients essential arterial hypertension (EAH). Design method: The case-control study involved 100 EAH stage II, 1-3 degrees blood pressure value (BP), high very cardiovascular risk. Among there were 21% (21) men, 79% (79) women, mean age 59.86±6.22y.o. control group consisted 60 practically healthy...
Objective: Metabolic violations, obesity and other related comorbidities are obvious in arterial hypertension. It is known that Hepatic Steatosis (HS) Arterial hypertension (AH) has to some extend common pathogenesis realized through metabolic immune mechanisms involving vascular digestive system injury, forming Gut-Liver axis, which remain mostly untouched recent studies. We aimed on evaluating the endothelial function mesenteric vessels remodeling depending I/D polymorphism of...
Objective: The aim of this study was to establish the role clinical complains and symptoms as risk factors for severe essential arterial hypertension (EAH) in patients with vitamin D deficiency. Design method: 100 EAH target-organ damage, moderate, high-very high cardiovascular were involved case-control study. 79.0% females 21.0% males, mean age 59.87 ± 8.02. They tested total serum 25-hydroxyvitamin concentration (immune luminescent test “MAGLUMI”, “SNIB”, China). All recruited taken...
Objective: The aim of the study was to analyze metabolic and hormonal parameters changes in patients with essential arterial hypertension (EAH) depending on vitamin D receptor gene (VDR, rs2228570) polymorphism. Design method: involved 100 suffering from EAH target-organ damaging, moderate, high or very cardiovascular risk. Among them were 79.0% (79) women 21.0% (21) men, an average age 59.87±8.02 yo. control group 60 practically healthy persons, matched by gender distribution. All...
Objective: The aim of our study was to evaluate the role AGT (rs4762) and GNB3 (rs5443) gene polymorphisms as risk factors for severe hypertension. Design method: case-control involved 100 patients with EAH stage II, 1-3 degrees blood pressure (BP), high very cardiovascular risk. Among there were 21% (21) men, 79% (79) women. mean age 59.86±6.22 y.o. control group consisted 60 almost healthy individuals relevant (49.13±6.28y.o.) gender distribution (63% - women, 37% men). polymorphism...
Primary/essential hypertension (PH) is the most common cause of left ventricular hypertrophy (LVH) and often associated with metabolic disorders. The aim study was to analyse dependence parameters on guanine nucleotide binding protein (G-protein) 3 subunit gene polymorphism (GN3, rs5443) in hypertensive patients.A cross-sectional involved 72 PH patients high very cardiovascular risk (29.16% men 70.84% women); average age 59.87 ± 7.98 y. control group included 48 healthy individuals (aged...
Renin-angiotensin aldosterone system plays a major role in blood pressure regulation. Aldosterone, synthesized the adrenal cortex by synthase is encoded cytochrome 11B2 gene (CYP11B2). The aim of study was to analyze association (CYP11B2) biallelic polymorphism (-344C/T) with Chronic Kidney Disease (CKD) patients essential arterial hypertension (EAH) West-Ukrainian population.One-hundred subjects EAH and target-organ damaging (2nd stage), moderate, high or very cardiovascular risk were...
The aim of the study was to analyze association CYP11B2 (-344C/T) gene polymorphism with lipids profile and aldosterone level changes in patients essential arterial hypertension (EAH).One-hundred subjects EAH target-organ damaging (2nd stage), moderate, high or very cardiovascular risk were involved case-control study. Among them 79.0% females 21.0% males, mean age 59.87 ± 8.02; disease duration from 6 25 years. Control group included 48 practically healthy persons relevant age. Gene...
To analyze the vitamin D and ionized calcium levels in patients with essential arterial hypertension (EAH) depending on AGT gene (rs699) polymorphism.72 subjects EAH target-organ damaging (2nd stage), moderate, high or very cardiovascular risk were involved case-control study. Among them, 70.84% (51) females 29.16% (21) males, mean age 59.87 ± 7.98 y o. Control group consisted of forty-eight practically healthy individuals relevant (49.13 6.28 o) sex distribution (62% females, 38% males)....
The crucial function of endothelium's regulatory mechanisms is to maintain the balance between Monoxide Nitrogen (NO) release and endothelium-derived contracting factors production. Therefore, it prognostically important clarify endothelial (EF) deterioration pathway through early biomarkers EF carotid intima media thickness (IMT) changes depending on GNB3 (rs5443) NOS3 (rs2070744) genes' polymorphism in essential arterial hypertension (EAH).One-hundred EAH patients with...
The study purpose was to analyze the association of angiotensinogen AGT (rs699) gene polymorphism with lipids` metabolism in patients essential arterial hypertension (EAH).The involved 72 suffering from EAH target-organ damaging, moderate, high or very cardiovascular risk. Among them, 70.84% (51) women and 29.16% (21) men, mean age 59.87 ± 7,98 y o. control group 50 practically healthy persons, matched by sex distribution. To examine a qualitative polymerase chain reaction made real-time...