A5000513039- Virus-based gene therapy research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Blood Pressure and Hypertension Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Hepatitis C virus research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Imaging and Diagnostics
- Emergency and Acute Care Studies
- Animal Genetics and Reproduction
- Cardiac Health and Mental Health
- Coronary Interventions and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Shoulder Injury and Treatment
- Cytomegalovirus and herpesvirus research
- Healthcare Systems and Technology
- Ovarian cancer diagnosis and treatment
- Telemedicine and Telehealth Implementation
- Diabetes Management and Education
- Trauma Management and Diagnosis
- HIV/AIDS drug development and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Health Systems, Economic Evaluations, Quality of Life
- Shoulder and Clavicle Injuries
- Endometrial and Cervical Cancer Treatments
Baylor University Medical Center
1997-2023
HealthPartners
2016-2022
Cincinnati Children's Hospital Medical Center
2011-2022
Pasadena City College
2018
Regions Hospital
2017
GNS Healthcare (United States)
2014-2017
Harvard University
2012
Cancer Research And Biostatistics
2009
University of Massachusetts Chan Medical School
2008
Baylor Jack and Jane Hamilton Heart and Vascular Hospital
2006
Application of novel machine learning approaches to electronic health record (EHR) data could provide valuable insights into disease processes. We utilized this approach build predictive models for progression prediabetes and type 2 diabetes (T2D).Using a analytical platform (Reverse Engineering Forward Simulation [REFS]), we built prediction model ensembles or T2D from an aggregated EHR sample. REFS relies on Bayesian scoring algorithm explore wide space, outputs distribution risk estimates...
A team approach is one of the most effective ways to lower blood pressure (BP) in uncontrolled hypertension, but different models for organizing team-based care have not been compared directly.A pragmatic, cluster-randomized trial 2 interventions adult patients with moderately severe hypertension (BP≥150/95 mm Hg): (1) clinic-based using best practices and face-to-face visits physicians medical assistants; (2) telehealth adding home BP telemonitoring home-based coordinated by a clinical...
Veterans with chronic posttraumatic stress disorder were evaluated for a history of blast concussion, controlling confounding conditions. Electroencephalograms analyzed by discriminant function traumatic brain injury. A difference was found in scores between veterans and without concussion. More members the group had attentional symptoms dysfunction. Combat remote injury have persistent electroencephalographic features as well problems. The authors hypothesize that these constitute type...
Abstract BACKGROUND Reports on the relation between anthropometric variables (height, weight) and physical activity with ovarian cancer have been inconclusive. The objective of current study was to extend investigation potential associations in Iowa Women's Health Study cohort. METHODS self‐reported incident studied a prospective cohort women ages 55–69 years who were followed for 15 years. Two hundred twenty‐three cases epithelial identified by linkage registry. RESULTS No association found...
Background. Human immunodeficiency virus (HIV) coinfection accelerates the rate of liver disease outcomes in individuals chronically infected with hepatitis C (HCV). It remains unclear to what degree combination antiretroviral therapy (ART) protects against HCV-associated failure. Methods. We evaluated 10 090 HIV/HCV-coinfected males from Veterans Aging Cohort Study Virtual Cohort, who had not initiated ART at entry, for incident hepatic decompensation between 1996 and 2010. defined...
Gaucher's disease, according to the present conception, may be defined as a nonhereditary congenital familial disease due disturbed lipoid metabolism with production of an abnormal substance (kerasin). This is stored by histiocytes reticulo-endothelial origin, giving rise typical Gaucher cell, which found in all tissues, chiefly spleen, lymph glands, liver and bone marrow, reticulo-endothelium present. Clinically, characterized splenomegaly, hepatomegaly, pigmentation skin, pinguecula-like...
Background: A recent meta-analysis concluded that there was no overall association between estrogen replacement therapy (ERT) and risk of epithelial ovarian cancer. However, several subsequent studies have suggested long-term ERT could increase cancer risk. Methods: We prospectively examined the with among 31,381 postmenopausal women in Iowa followed for 15 years. Results: Women who were using at baseline had an elevated multivariate-adjusted relative (1.7; 95% confidence interval [CI] =...
Background: Known possible consequences of proximal humerus fractures include impaired shoulder function, decreased independence, and increased risk for mortality. The purpose this report is to describe the survival independence elderly patients with humerus, treated in our institution, relative patient characteristics treatment method. Methods: Retrospective cohort study from 2006 2012. Setting: Community-based hospital level 1 designation. Patients/Participants: Three hundred nineteen ≥60...
Highly active antiretroviral therapy (HAART) has reduced herpes zoster (HZ) incidence in HIV-infected children, yet it remains common.
Nonadherence to antipsychotic treatment increases the likelihood of relapse and progressive symptomatology in patients with schizophrenia. Atypical long-acting injectables, including paliperidone palmitate (PP), may increase adherence improve symptoms. This study compared assessed predictors patterns symptom remission among schizophrenia treated PP versus atypical oral therapy (OAT) community behavioral health organizations (CBHOs).This retrospective cohort analysis evaluated 763 new (PP-N;...
For patients with epidermal growth factor receptor-mutated (EGFRm) locally advanced/metastatic non-small cell lung cancer (mNSCLC) whose disease has progressed on or after osimertinib and platinum-based chemotherapy (PBC), no uniformly accepted standard of care exists. Moreover, limited efficacy treatments indicates an unmet medical need, which is being addressed by ongoing clinical investigations, including the HERTHENA-Lung01 (NCT04619004) study patritumab deruxtecan (HER3‑DXd). However,...
Chicken-embryo-lethal-orphan (CELO) virus was shown to transform hamster-embryo fibroblastic cells in vitro. The first signs of infection were at 24 hours when pyramidal or stellate cell forms observed a disorganized growth pattern. After 4 passages elements gave way epithelioid-like cells. Virus production decreased as the number transformed increased. A virus-specific intranuclear “T” antigen most by immunofluorescent techniques. Cells from seventh and twelfth induced fibrosarcomas...
To examine the relationship of parent and child ratings illness uncertainty to depressive symptomotology in children with a chronic using mediational model framework.Mother-child dyads (N = 103 pairs) each completed measures perceived uncertainty, while youth also measure symptomotology.Maternal was directly related symptoms; however, this mediated by uncertainty.It would appear that key mechanism which parent-related influences symptoms is through underscoring importance examining cognitive...
This study has shown that chicken-embryo-lethal-orphan virus (CELO), an avian adenovirus, can transform human amnion cells. Cellular changes were evident 21 days after infection, when areas of rapidly proliferating pleomorphic cells observed. Three continuous lines isolated which consisted mainly spindle-shaped All contained the CELO-specific “T” antigen. Inoculations hamsters with 1–6.5 × 106 in cheek pouch produced growing fibrosarcomas.
To evaluate the utility of monitoring emergency medical services (EMS) call patterns to identify older adults who may benefit from targeted fall prevention and strategies.Retrospective chart review EMS fall-related care. The HealthEMS database for community surveyed was queried January 1, 2007, through December 31, 2016. Fall-related calls individuals aged 60 were identified used determine which had subsequent needed transport hospital over study time period.Medium-sized suburban...
The coronavirus disease 2019 (COVID-19) pandemic instigated major changes in care delivery, but our understanding of how the rapid transition from in-person to telehealth encounters affected patients with chronic conditions such as type 2 diabetes remains incomplete. This study examined primary encounters, A1C testing rates, and likelihood meeting guidelines before during first 9 months COVID-19 a large health system. It found significant decreases utilization rates guidelines, primarily...
Introduction Periodontitis is a common oral disease associated with coronary artery (CAD), cerebrovascular (CBVD) and type 2 diabetes (T2D). We studied if periodontitis treatment improves clinical outcomes reduces medical care costs in patients CAD, CBVD or T2D. Methods used clinic records claims data from health system to identify T2D, assess periodontal treatments, hospitalizations, (total, inpatient, outpatient, pharmacy), glycated hemoglobin, cardiovascular events, death following...
Abstract Background Central nervous system (CNS) vasculopathy has been reported in human immunodeficiency virus–infected (HIV+) adults and children. In children, it often presents with HIV encephalopathy, stroke, or intracerebral aneurysms. The etiology, incidence, risk factors of HIV-associated CNS children are unknown. Methods We identified HIV+ a diagnosis other cerebrovascular events among enrolled between 1993 2004 2 prospective, multicenter cohort studies. Demographic laboratory data,...