A5052980724- Palliative Care and End-of-Life Issues
- Childhood Cancer Survivors' Quality of Life
- Cancer survivorship and care
- Patient Dignity and Privacy
- Ethics in medical practice
- Grief, Bereavement, and Mental Health
- Pain Management and Opioid Use
- Cancer-related cognitive impairment studies
- Family Support in Illness
- Psychosomatic Disorders and Their Treatments
- Schizophrenia research and treatment
- Immune cells in cancer
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Psychotherapy Techniques and Applications
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Electroconvulsive Therapy Studies
- Hippo pathway signaling and YAP/TAZ
- Family and Patient Care in Intensive Care Units
- Exercise and Physiological Responses
- Treatment of Major Depression
- Pharmacological Effects and Toxicity Studies
- Coenzyme Q10 studies and effects
- vaccines and immunoinformatics approaches
Oregon Health & Science University
2021-2025
Dana-Farber Cancer Institute
2021-2022
Harvard University
2022
Pennsylvania State University
2021
Duke University
2014-2021
Duke University Health System
2016-2020
Ithaca College
2019
OHSU Knight Cancer Institute
2018
Cancer Institute (WIA)
2018
Durham VA Medical Center
2015-2016
<h3>Importance</h3> Patients with acute myeloid leukemia (AML) receiving intensive chemotherapy experience substantial decline in their quality of life (QOL) and mood during hospitalization for induction often receive aggressive care at the end (EOL). However, role specialty palliative improving QOL this population is currently unknown. <h3>Objective</h3> To assess effect integrated oncology (IPC) on patient-reported EOL outcomes patients AML. <h3>Design, Setting, Participants</h3> We...
Telemedicine-based diabetes management improves outcomes versus clinic care but is seldom implemented by healthcare systems. In order to advance telemedicine-based as a practical option for veterans with persistent poorly controlled mellitus (PPDM) despite clinic-based care, we evaluated comprehensive telemedicine intervention that specifically designed delivery using existing Veterans Health Administration (VHA) clinical staffing and equipment.We conducted 6-month randomized trial among 50...
Palliative care (PC) providers often prescribe psychotropic medications to address psychological and physical suffering of patients with serious medical illness. Consideration must be given the significant comorbidities patient when selecting a medication. This article seeks provide guidance on how safely effectively select agent for depression, anxiety, other distressing symptoms To do so, we draw upon team physicians pharmacist training in psychiatry PC highlight "Top 10" tips medication relief
Skeletal muscle sarcoplasmic reticulum (SR) is shown to contain an NADH-dependent oxidase (NOX) that reduces molecular oxygen generate superoxide. Its activity coupled activation of the Ca 2 + release mechanism, as evident by stimulation in rate high-affinity ryanodine binding. NOX activity, production superoxide, not derived from mitochondria but SR origin. The preparation also contains a significant NADH which superoxide and appears be mitochondrial This component preferentially associated...
Analysis of The Cancer Genome Atlas and other published data head neck squamous cell carcinoma (HNSCC) reveals somatic alterations the Hippo-YAP pathway in approximately 50% HNSCC. Better strategies to target YAP1 transcriptional complex are sought. Here, we show that FAT1, an upstream inhibitor YAP1, is mutated either by missense or truncating mutation 29% Comprehensive proteomic drug-screening studies across pan-cancer models confirm FAT1-mutant HNSCC exhibits selective higher sensitivity...
In a head and neck squamous cell carcinoma (HNSCC) "window of opportunity" clinical trial, we reported that trametinib reduced MEK-Erk1/2 activation resulted in tumor responses subset patients. Here, investigated resistance to molecular correlates HNSCC lines patient samples.HNSCC were treated with generate resistant lines. Candidate bypass pathways assessed using immunoblotting, CRISPR knockout, survival assays. Effectiveness combined verteporfin targeting was evaluated. Patient-derived...
Background It has been shown previously that integrated palliative care for patients with acute myeloid leukemia (AML) during intensive chemotherapy leads to improvements in quality of life (QOL) and mood. Coping mediate interventions advanced cancer; the mechanisms by which occur among AML remain unexplained. Methods The authors conducted a secondary analysis data from multisite randomized trial oncology (IPC; n = 86) versus usual (n 74) hospitalized undergoing chemotherapy. IPC met at...
Mental health issues are widespread and significant among individuals with serious illness. Among patients receiving palliative care (PC), psychiatric comorbidities common impact patient quality of life. Despite their prevalence, PC clinicians face challenges in effectively addressing the intricate relationship between medical disorders due to complex, intertwined bidirectionally influential nature. This article, created collaboratively a team psychiatric-palliative experts, is second...
Limited data exist on factors associated with early quality of life (QOL) response to palliative care (PC) in patients undergoing hematopoietic cell transplantation (HCT). We conducted a secondary analysis from two randomized clinical trials PC versus usual adults hematologic malignancies HCT. measured patient-reported QOL, physical and psychological symptoms, coping (categorized as approach-oriented avoidant) at time HCT admission, 2-weeks, 3- 6- months post-HCT. clinicians completed weekly...
12011 Background: Patients (pts) with high HCT-Comorbidity Index scores (HCT-CI of ≥3), older age (≥65 years), and/or who are frail per gait speed (<0.8 meters/second) have increased morbidity and mortality after allo-HCT compared to younger healthier counterparts. We report the phase II analysis (PIIA) interim III primary outcome (PIIIA) a seamless II/III prospective, randomized clinical trial conducted at 11 transplant centers test new approaches improve quality life (QOL) in this...
BACKGROUND Patients with acute myeloid leukemia (AML) receiving intensive chemotherapy face a life‐threatening illness, isolating hospitalization, and substantial physical psychological symptoms. However, data are limited regarding risk factors of posttraumatic stress disorder (PTSD) symptoms in this population. METHODS The authors conducted secondary analysis from 160 patients high‐risk AML who were enrolled supportive care trial. PTSD Checklist‐Civilian Version was used to assess at 1...
Head and neck squamous cell carcinomas (HNSCC) are well suited for cancer vaccination strategies. In addition to tumor-associated antigens (TAAs) endogenous retrovirus (ERV) encoded proteins, HNSCCs have a relatively high tumor mutational burden encoding potential neoepitopes. Peptide vaccine candidates prioritized by predicted high-affinity major histocompatibility complex (MHC) class I with MHC-II affinity largely not being considered. Herein, we extend previous studies evaluate...
Addressing the psychiatric aspects of serious illness in palliative care (PC) is crucial to both delivery and outcomes. Psychiatric comorbidities are common among patients with PC needs can significantly impact their total burden symptomatic distress, overall quality life, functional independence, healthcare utilization. Yet, these often deferred mental health consultant teams context busy services limited human resources. To provide comprehensive person-centered care, clinicians must...
12000 Background: Patients with AML receiving intensive chemotherapy experience substantial decline in their quality of life (QOL) and mood during hospitalization for induction often receive aggressive care at the end (EOL). We sought to examine effect integrated palliative oncology on QOL, mood, post-traumatic stress (PTSD) symptoms, EOL outcomes patients AML. Methods: conducted a multi-site randomized trial (n = 86) versus usual 74) undergoing chemotherapy. assigned intervention were seen...
We have previously demonstrated that H 2 O at millimolar concentrations induces Ca 2+ release from actively loaded sarcoplasmic reticulum (SR) vesicles and biphasic [ 3 H]ryanodine binding behavior. Considering hypochlorous acid (HOCl) is a related free radical has been to be more effective oxidant of proteins, we evaluated the effects HOCl on -channel mechanism. In concentration-dependent manner, activates SR channel rapid vesicles. HOCl-induced inhibited in presence DMSO. High-affinity...
Hematologic malignancies differ in several important ways from solid organ cancers, and warrant a unique approach to palliative care (PC) integration. As PC has moved upstream end-of-life care, clinicians are increasingly asked see patients with hematologic malignancies. Unfortunately, many specialists have limited knowledge of these diseases, had few prior opportunities participate their care. This article, written by oncologists specialists, seeks educate teams about the features...
Background: Patients (≥60 years) with acute myeloid leukemia (AML) often receive intense health care utilization at the end of life (EOL). However, factors associated their use EOL are unknown. Methods: We conducted a secondary analysis 168 deceased patients AML within United States. assessed quality (QOL) (Functional-Assessment-Cancer-Therapy-Leukemia), and psychological distress (Hospital-Anxiety-and-Depression Scale [HADS]; Patient-Health-Questionnaire-9 [PHQ-9]) diagnosis. used...