A5019156974- Amino Acid Enzymes and Metabolism
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Chemical Synthesis and Analysis
- Biochemical and Molecular Research
- Polyamine Metabolism and Applications
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
KU Leuven
2020-2023
Abstract Metabolic rewiring is a hallmark of cancer that supports tumor growth, survival, and chemotherapy resistance. Although normal cells often rely on extracellular serine glycine supply, significant subset cancers becomes addicted to intracellular serine/glycine synthesis, offering an attractive drug target. Previously developed inhibitors synthesis enzymes did not reach clinical trials due unfavorable pharmacokinetic profiles, implying further efforts identify clinically applicable...
Abstract Background One-third of cancers activate endogenous synthesis serine/glycine, and can become addicted to this pathway sustain proliferation survival. Mechanisms driving metabolic rewiring remain largely unknown. Methods NKX2–1 overexpressing knockdown/knockout T-cell leukaemia lung cancer cell line models were established study using ChIP-qPCR, immunoblotting, mass spectrometry, invasion assays. Findings therapeutic relevance validated in mouse confirmed patient datasets. Results...
ABSTRACT Metabolic rewiring is a hallmark of cancer that supports tumor growth, survival and chemotherapy resistance. While normal cells often rely on extracellular serine glycine supply, significant subset cancers becomes addicted to intracellular serine/glycine synthesis, offering an attractive drug target. Previously developed inhibitors synthesis enzymes did not reach clinical trials due unfavorable pharmacokinetic profiles, implying further efforts identify clinically applicable drugs...
<p>This file describes all yeast experiments and includes supplementary tables S1-S3 figures S1-S10.</p>
<p>This file describes all yeast experiments and includes supplementary tables S1-S3 figures S1-S10.</p>
<div>Abstract<p>Metabolic rewiring is a hallmark of cancer that supports tumor growth, survival, and chemotherapy resistance. Although normal cells often rely on extracellular serine glycine supply, significant subset cancers becomes addicted to intracellular serine/glycine synthesis, offering an attractive drug target. Previously developed inhibitors synthesis enzymes did not reach clinical trials due unfavorable pharmacokinetic profiles, implying further efforts identify...
<div>Abstract<p>Metabolic rewiring is a hallmark of cancer that supports tumor growth, survival, and chemotherapy resistance. Although normal cells often rely on extracellular serine glycine supply, significant subset cancers becomes addicted to intracellular serine/glycine synthesis, offering an attractive drug target. Previously developed inhibitors synthesis enzymes did not reach clinical trials due unfavorable pharmacokinetic profiles, implying further efforts identify...
Abstract Metabolic reprogramming is a well-established hallmark of cancer cells, which supports tumor growth, survival, and chemotherapy resistance. In this respect, subset cancers gets addicted to intracellular serine/glycine synthesis via overexpression the enzymes PHGDH, PSAT1, PSPH or SHMT1/2. This cancer-specific dependency highlights novel therapeutic opportunity, as normal cells solely rely on serine glycine uptake from their environment. Well established examples...