A5081276440- Drug Transport and Resistance Mechanisms
- Algal biology and biofuel production
- Biocrusts and Microbial Ecology
- Skin Protection and Aging
- Genomics, phytochemicals, and oxidative stress
- melanin and skin pigmentation
- Cancer therapeutics and mechanisms
- Laser Applications in Dentistry and Medicine
- Photosynthetic Processes and Mechanisms
- Environmental Toxicology and Ecotoxicology
- Synthesis of Organic Compounds
- DNA and Nucleic Acid Chemistry
- Phytochemicals and Antioxidant Activities
- Fatty Acid Research and Health
- Photodynamic Therapy Research Studies
- RNA Interference and Gene Delivery
- Aquaculture Nutrition and Growth
- Garlic and Onion Studies
- Aquatic Ecosystems and Phytoplankton Dynamics
- Neuroscience and Neuropharmacology Research
- DNA Repair Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Synthesis and biological activity
- Cardiac Ischemia and Reperfusion
- Phytochemistry and biological activity of medicinal plants
Universidade Federal do Rio Grande
2016-2025
Universidade Federal do Rio Grande do Sul
2007-2010
Objective: C-Phycocyanin (C-PC) is a photosynthetic pigment with interesting therapeutic properties. However, its effectiveness in modulating the immune system cell populations has not been elucidated. We analyzed action of C-PC on modulation mice system.
Onion (Allium cepa) is being studied as a potential anticancer agent, but little known regarding its effect in multidrug resistance (MDR) cells.In this work, the cytotoxicity of crude onion extract (OE) and fractioned (aqueous, methanolic ethyl acetate), well some compounds (quercetin propyl disulfide) were evaluated Lucena MDR human erythroleukemic K562 parental cell line.The capacity OE to induce apoptosis and/or necrosis these cells, possible participation oxidative stress DNA damage also...
Background:: Quercetin has potential against the Multidrug Resistance (MDR) phenotype, but with low bioavailability. The increase in bioavailability can be obtained nanostructures. Objective:: To analyze effects of quercetin and its nanoemulsion on MDR non-MDR cells. Methods: We used high-pressure homogenization for production; Trypan Blue cytostatic/cytotoxicity assays; Epifluorescence microscope (with specific probes) apoptosis DNA damage; Real-Time PCR gene expression; AutoDock Vina...
The gene expression of Oct-4, a transcription factor and hematopoietic stem cell marker, is higher in Lucena lines, which MDR, the Alox-5 has also been implicated differentiation some lines. aim this study was to compare response PMA-induced MDR non-MDR cells. We observed megakaryocytes K562 line, non-MDR. Nanog genes downregulated that Mdr-1 upregulated line contained number than non-MDR, but not altered by PMA, as well expression. However, downregulated. Alox-5, Mdr-1, Nanog, Oct-4 Sox-2...
Abstract Multidrug resistance (MDR) is an obstacle in cancer treatment. An understanding of how tumoral cells react to oxidants can help us elucidate the cellular mechanism involved resistance. Microcystins are cyanobacteria hepatotoxins known generate oxidative stress. The aim this study was compare sensitivity microcystins human cell lines with (Lucena) and without (K562) MDR phenotype. Endpoints analyzed were effective concentration 50% exposed (EC 50 ), antioxidant enzyme activity, lipid...
ASA (acetylsalicylic acid) is an NSAID (non-steroidal anti-inflammatory drug). has gained attention as a potential chemopreventive and chemotherapeutic agent for several neoplasms. The aim of this study was to analyse the possible antitumoural effects in two erythroleukaemic cell lines, with or without MDR (multidrug resistance) phenotype. mechanism action different concentrations were compared K562 (non-MDR) Lucena (MDR) cells by analysing viability, apoptosis necrosis, intracellular ROS...
Benzo[a]pyrene (BaP) is ubiquitously distributed in the environment, being considered most phototoxic element among polycyclic aromatic hydrocarbon (PAHs). In presence of oxygen, PAHs can act as a photosensitizer by means promoting photo-oxidation biological molecules (photodynamic action, PDA). Thus, present study analyzed photodynamic action BaP under UVA irradiation (BaP + UVA) and its oxidative effects on K562 cells. The evaluation kinetics showed that highest intracellular concentration...
The recently developed therapeutic strategies have led to unprecedented improvements in the control of metastatic melanoma and survival specific subgroups patients. However, drug resistance, low response rates, undesired side effects make these treatments not suitable or tolerable for all patients, chemotherapeutic appear still indispensable, at least New combinatory are also under investigation as tailored salvage therapies, including combined immunotherapy with conventional chemotherapy....
Abstract Healthcare‐associated infections (HAI) are illnesses acquired during healthcare and often the most important adverse event healthcare. With aim of increasing effectiveness disinfection/decontamination processes in health service with safe not promote microbial resistance, we propose development portable equipment associated type C ultraviolet light (UVC). The efficiency irradiance emitted by (at dosages 3.5, 5.0, 60 mJ/cm 2 ) was determined action exerted after exposure against four...
Saxitoxins (STXs) are potent neurotoxins that also induce cytotoxicity through the generation of reactive oxygen species. Carbon nanotubes (CNTs) nanomaterials can promote a Trojan horse effect, facilitating entry toxic molecules to cells when adsorbed nanomaterials. The interaction pristine single-walled (SW)CNTs and carboxylated (SWCNT-COOH) with STX was evaluated by ab initio simulation bioassays using cell line HT-22. Cells (5 × 104 cells/mL) were exposed SWCNT SWCNT-COOH μg mL-1 ), (200...
Neste estudo foram estabelecidas a composição específica e sazonalidade da ocorrência das aves na área do Campus Carreiros Fundação Universidade Federal Rio Grande (FURG), Grande, RS. Para isso realizadas saídas de campo entre maio 1999 agosto 2005. Em média, 15 observações cada estação ano pelo menos uma seção mensal captura com redes neblina, partir novembro 2003. A foi percorrida modo amostrar os diferentes tipos ambientes existentes no local. identificação espécies feita por análise...
O aprendizado da Biologia vai além memorização de informações, necessitando do entendimento dos conceitos e termos área. Entretanto, o terminologia científica se apresenta como um desafio para os estudantes, pois a maioria não familiariza com significado termos. Desta forma, estudantes acabam por memorizar forma superficial que poderia ser aprendido através lógica. Assim, objetivo trabalho foi mostrar Etimologia pode contribuir ensino aprendizagem significativa vocabulário esses podem formar...
This study analyzed water quality in regions around Patos lagoon (Southern Brazil) that are under anthropogenic pressure. Water samples were collected from five different sites, including one used as a source for human consumption (COR) and others known to be influenced by activities (IP). Danio rerio (Teleostei, Cyprinidae) organisms exposed 24h these samples, plus control group. It was observed that: (1) reactive oxygen species levels lower COR IP than the group; (2) glutamate-cysteine...