Lithium remains first choice as maintenance treatment for bipolar affective disorder. Yet, about half of all individuals may stop their at some point, despite lithium’s proven benefits concerning the prevention severe episodes and suicide. Retrospective cohort study in Swedish region Norrbotten into causes lithium discontinuation. The was set up to (1) test whether patients with disorder or schizoaffective disorder, treated therapy, were more likely discontinue because adverse effects than...

Rural communities have a higher burden of cardiovascular risk factors than urban communities. In Sweden, socioeconomic transition and urbanization led to decreased populations in rural areas changing characteristics the remaining inhabitants. We investigated Northern Sweden. The 2009 Sweden MONICA Study invited random sample 2,500 people, 25 74 years 69.2% participated. Community size was classified as = <1,000 inhabitants, town 1,000-15,000, or urban/city= >15,000. adjusted our analysis for...

Abstract Background Tularemia is an important reemerging disease with a multimodal transmission pattern. Treatment outcomes of current recommended antibiotic regimens (including ciprofloxacin and doxycycline) remain unclear. In this retrospective cohort study, we report clinical, laboratory, geographical, treatment laboratory-confirmed tularemia cases over 11-year period in Northern Sweden. Methods Data from reported (aged &amp;gt;10 years at time study) Norrbotten county between 2011 2021...

Background: The association between lithium and thyroid dysfunction has long been known. However, it remains unknown if lithium-associated hypothyroidism is reversible once treatment stopped. Aims: To determine whether was in patients who subsequently discontinued lithium. Methods: A retrospective cohort study the Swedish region of Norrbotten into effects side- other drugs for relapse prevention (Lithium – Study Effects Side Effects). For this particular study, we reviewed medical records...

Background Prospective birth cohorts are essential for identifying associations between exposures and outcomes. However, voluntary participation introduces a potential bias due to self selection since the persons that chose participate may differ in background characteristics behaviors.Objectives To investigate self-selection Nutritional impact on Immunological maturation during Childhood relation Environment (NICE) cohort northern Sweden.Methods Women NICE (N = 621) were compared...

Background The effect of primary prevention cardiovascular disease is debated. Västerbotten Intervention Programme (VIP) an individual and community-based public health programme that comprises the whole county (VB). In neighbouring Norrbotten (NB), no programmes have been implemented. Method Between 1994 2014, five surveys were performed in two counties on persons aged 40 to 75 years within Northern Sweden MONICA Study. number subjects participating was 6600 (75.4%). We compared time trends...

Abstract Background The incidence of post-traumatic osteoarthritis (OA) following intraarticular knee fractures has been estimated to be relatively high but it varies substantially between different reports. In this study we sought assess the prevalence radiographic OA secondary tibial plateau (TPF). second aim was report medium- and long-term functional outcomes investigate whether there were any risk factors associated with these outcomes. Methods We retrospectively reviewed documentation...

Objective To investigate the relationship between self-rated health, adjusted for standard risk factors, and myocardial infarction. Design Population-based prospective cohort study. Setting Enrolment took place 1990 2004 in Västerbotten County, Sweden Participants Every year, persons total population, aged 40, 50 or 60 were invited. Participation rate was 60%. The consisted of 75 386 men women. After exclusion stroke infarction before, within 12 months after enrolment death enrolment, 72 530...

Type 2 diabetes has been linked to fatigue, but results on type 1 are ambiguous. Our aim was determine if is associated with fatigue and whether the due complications or disease itself.The Multidimensional Fatigue Inventory (MFI-20), submitted all 435 adult patients in National Diabetes Register at Sunderby Hospital clinic a control group of 2500 persons. The participation rate 62% both groups.Type greater 1.4-point difference (0.9-1.9, 95% CI) general scale 4-20. an independent predictor as...

Currently, the evidence for lithium as a maintenance treatment bipolar disorder type II (BD-II) remains limited. Guidelines commonly extrapolate recommendations BD-II from available I (BD-I). Comparing impact of discontinuation is one way assessing effectiveness in both groups.To compare on hospital admissions and self-harm patients with BD-I or schizoaffective (SZD) other disorder.Mirror-image study, examining within 2 years before after patient groups. This study was part retrospective...

Introduction Mood stabilisers and other psychotropic drugs can lead to serious adverse drug events (ADEs). However, the incidence remains unknown. We aimed (a) determine of ADEs in patients with bipolar or schizoaffective disorders, (b) explore role lithium exposure, (c) describe aetiology. Methods This study is part LiSIE (Lithium—Study into Effects Side Effects) retrospective cohort study. Between 2001 2017, Swedish region Norrbotten, a diagnosis disorder, were screened for drugs, having...

Background: Lithium-associated hyperthyroidism is much rarer than lithium-associated hypothyroidism. Yet, it may be of substantial clinical significance for affected individuals. For instance, could destabilise mood, mimic manic episodes and impact physical health. Only few studies have explored incidence rates hyperthyroidism. Even fewer compared according to lithium exposure history. Objectives: To determine the treatment on rate in patients with bipolar or schizoaffective disorder assess...

Self-rated health (SRH) accounts comprehensively for many domains. The aim of this paper was to investigate time trends and associations between age-comparative self-rated some known determinants in a general population aged 24-34 years. Population-based cross-sectional surveys were performed 1990, 1994, 1999, 2004, 2009 2014 Northern Sweden. Out 3500 invited persons, 1811 responded. Comparative SRH measured on three-grade ordinal scale by the question: "How would you assess your condition...

Several studies have examined various parameters and experiences when patients suffer their first myocardial infarction (MI), but knowledge about they second MI is limited. To compare risk factors for MI, that is, diabetes, hypertension smoking, the events in men women affected by two MIs to analyse time intervals between MIs. A retrospective cohort study of 1017 aged 25–74 years with from 1990 through 2009 registered Northern Sweden MONICA registry. More than diabetes are smokers at MI....

The main objective was to report mechanisms and precursors for post-endovascular aneurysm repair (EVAR) rupture. second apply a structured protocol explore whether these factors were identifiable on follow up computed tomography (CT) prior third study the incidence, treatment, outcome of post-EVAR rupture.This multicentre, retrospective patients treated with standard EVAR at five Swedish hospitals from 2008 2018. Patients identified Swedvasc registry. Medical records reviewed 2020. Index...

(1) Background: Few studies have explored the impact of lithium intoxication on heart. (2) Methods: We examined electrocardiogram (ECG) changes associated with in framework LiSIE (Lithium—Study into Effects and Side Effects) retrospective cohort study. analysed ECGs before, during, after intoxication. (3) Results: Of 1136 patients included, 92 had experienced 112 episodes For 55 episodes, there was an ECG available at time; for 48 a reference before and/or Lithium led to statistically...

To evaluate patient-reported outcome measures in 2 different multimodal pain rehabilitation programmes and to determine whether outcomes are related sex or age at 1-year follow-up.Longitudinal retrospective study.Patients who had participated 1 of centres. A total 356 women 83 men, divided into 3 groups.Data from the Swedish Quality Registry for Pain Rehabilitation regarding activity physical functions, intensity, health status emotional functions analysed with descriptive...

Objectives: To examine if tooth loss or treatment with different prosthetic replacements are associated oral health-related quality of life (OHRQoL HRQoL) among persons dependency and functional limitations.Material Methods: Comparisons between results questionnaires clinical data (number teeth, Eichner index, presence, type, condition replacements) from a population 180 individuals limitations sampled the register increased financial support in Norrbotten County, Sweden.Results: The...

Background: At the beginning of COVID-19 pandemic, concerns arose about a possible rise in alcohol consumption. Early surveys, however, more commonly pointed towards decrease use. But studies based on self-reports may underestimate They also depend population sampled. Because border closures and gastronomy restrictions, countries with centralised sales provided unique opportunity to study total domestic consumption during pandemic without influence private import or reliance self-reports....

Breast cancer liver metastases (BCLM) is a common cause of breast cancer-related death. The prognostic and predictive value receptor expression St Gallen classification challenged by status discordance in distant metastases. aim this study was to determine the rate conversion from BCLM impact on survival.Patients registered with two Swedish national registers were recruited retrospectively. Data primary collected, as well information about factors for survival. subtype analyzed. A Cox...

Background: Knowledge is limited concerning the type of symptoms and time from onset to first medical contact at second myocardial infarction in same patient. Aim: This study aimed describe infarctions men women affected by two infarctions. Furthermore, aim was identify factors associated with prehospital delays ≥2 h infarction. Methods: A retrospective cohort 820 patients aged 31–74 years a 1986 through 2009 registered Northern Sweden MONICA registry. Results: The most common reported among...

The aim of this study was to compare the prevalence tooth loss and prosthetic treatments in dependent, functionally impaired individuals with general population.Data collected from 250 subjects a register covering dependent Sweden were compared data matched controls. variables included number teeth, loss, different jaw regions.The group had lower mean teeth higher proportion complete than control group. Dentures more common group, fixed prostheses, including dental implants, Gender-based...