A5025481013- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Liver Disease and Transplantation
- Pharmaceutical Practices and Patient Outcomes
- Pharmacological Effects and Toxicity Studies
- Organ Donation and Transplantation
- Pregnancy and Medication Impact
- Neurological Complications and Syndromes
- Medication Adherence and Compliance
- Polyomavirus and related diseases
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Renal and Vascular Pathologies
- Liver Disease Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Cytomegalovirus and herpesvirus research
- Organ and Tissue Transplantation Research
- Opioid Use Disorder Treatment
- Complement system in diseases
- Prenatal Substance Exposure Effects
- Patient Safety and Medication Errors
- Blood donation and transfusion practices
- Potassium and Related Disorders
- Parvovirus B19 Infection Studies
Medical University of South Carolina
2014-2024
Astellas Pharma (Japan)
2020
Kidney Health Australia
2019
Zhaotong University
2019
National Cancer Registry
2019
RWTH Aachen University
2018
SUNY Upstate Medical University
2015
Syracuse VA Medical Center
2015
Background Medication reconciliation is one of the more challenging aspects inpatient care, and its accuracy paramount to safe transitions care. Studies have shown that pharmacists a role in medication through improving patient safety avoiding costs associated with errors. The wide-scale use this process has been limited by time constraints, cost, lack resources. Objective This study evaluates impact resolving errors, decreasing readmission rates, reducing institutional during discharge...
Although kidney transplant recipients at the authors' institution had a short length of stay (LOS), delayed discharges and early readmissions were common; medication use safety core these issues. A multidisciplinary quality improvement initiative was developed that targeted eliminating The team key initiatives including improved reconciliation, development diabetes management service, discharge dispensing, delivery, education, scrutiny. Follow-up analysis demonstrated reduced discrepancies...
Abstract The aim of this study was to assess the long‐term safety and clinical outcomes associated with utilization highly steatotic donor livers utilizing a specific donor/recipient matching algorithm. This prospective, observational, single‐center, 10‐yr follow‐up study. Highly were utilized according algorithm that guided surgeon use organs judiciously in low‐risk recipients. initially compared fat assessment based on frozen‐section Ehrlich's hematoxylin eosin (H&E) reperfusion biopsy...
Abstract The aim of this study was to examine the impact pre‐existing diabetes mellitus ( DM ) on acute rejection, graft loss, and mortality following kidney transplant whether glycemic control or cardiovascular disease CVD risk with medications influenced outcomes. This a cohort 1002 renal transplants conducted between 2000 2008. Patients were included if they received within allotted time at least 18 yr age. Cox regression used assess failure, death controlling for relevant...
In Brief Objective: The aim of this study was to determine the safety and efficacy induction with rabbit antithymocyte globulin (RATG) compared interleukin-2 receptor antagonists in a racially diverse kidney transplant patient population under modern immunosuppression. Background: optimal therapy patients at risk for rejection, particularly black recipients, era immunosuppression flow cytometry-based cross-matching is unclear. Methods: This prospective, risk-stratified, randomized,...
Abstract Studies have continued to evaluate risk factors associated with post‐transplant non‐adherence in pediatric patients. However, many of these studies fail how can be utilized predict MNA . The aims this study were (i) determine salient develop an adequate predictive model and (ii) assess transplant outcomes based on the presence a large, diverse cohort KTX recipients. One hundred seventy‐five solitary recipients transplanted from 1999 2013 included. AA, males, older patients, those...
Summary Background and objectives BK virus is an infection in kidney transplantation patients jeopardizing graft survival. Unfortunately, there no consensus on treatment of viremia nephropathy. Leflunomide has been studied for the nephropathy, but are limited data utility leflunomide therapeutic drug monitoring. This study aimed to determine if a pharmacodynamic relationship exists between viral load reduction metabolite, A77 1726, serum concentrations. Design, setting, participants, &...
The development, testing, and preliminary validation of a technology-enabled, pharmacist-led intervention aimed at improving medication safety outcomes in kidney transplant recipients are described.Medication issues, encompassing errors (MEs), nonadherence, adverse drug events (ADEs), predominant cause poor after transplantation. However, limited number clinical trials assessing the effectiveness technology have been conducted. Through an iterative, evidence-based approach,...
Graft thrombosis following pancreas transplantation is the leading non-immunologic cause of graft loss. Routine systemic anticoagulation controversial because an increased bleeding risk.This was a retrospective, single-center analysis including all transplants performed over 9 years evaluating use low-dose heparin in early postoperative period. Clinical outcomes were partial and complete within 30 days, events, relaparotomy rates, 30-day patient survival. Multivariate regression to identify...
Modern immunosuppressant regimens have significantly decreased acute rejection rates, but may increased the risk of graft loss driven by adverse drug reactions (ADRs) and medication errors (MEs). The objectives this study were to determine incidence factors for MEs ADRs association between transplant outcomes these events.This was a post hoc analysis prospective, randomized trial that included patients aged>18 years received solitary renal at an academic medical center recruited March 2009...
A lack of research exploring post-transplant process optimization to reduce readmissions and increasing readmission rates at our center from 2009 2013 led this study, aimed assessing the effect patient factors on 30-d after kidney transplantation. This was a retrospective case-control study in adult transplant recipients. Univariate multivariate analyses were utilized assess determinants readmissions. 384 patients included; significantly associated with graft loss death (p = 0.001). Diabetes...
Study Objective To determine the incidence, risk factors, and clinical outcomes associated with clinically significant medication errors or adverse drug events in kidney transplant recipients. Design Retrospective observational study. Setting Transplant center at an academic medical center. Patients A total of 476 adults who received transplants between June 2006 July 2009. Measurements Main Results Severe (medication‐related problems [ MRP s]) were identified by record review. Only...
Abstract Background Cytomegalovirus ( CMV ) infection is one of the most common and important opportunistic infections following kidney transplantation. It causes significant morbidity mortality. Valganciclovir VGCV drug choice for prophylaxis to prevent infection. Methods We conducted a post‐hoc analysis randomized controlled trial in 187 transplant recipients evaluate impact dosing renal function on development Results conclusion The results demonstrate that variables were independent risk...
The complex life-cycle of the human malaria parasite Plasmodium falciparum requires a high degree tight coordination allowing to adapt changing environments. One major challenges for is human-to-mosquito transmission, which starts with differentiation blood stage parasites into transmissible gametocytes, followed by rapid conversion gametocytes gametes, once they are taken up blood-feeding Anopheles vector. In order pre-adapt this change host, store transcripts in stress granules that encode...
<b><i>Background/Aims:</i></b> There are no published studies assessing the safety and efficacy of thiazides as antihypertensives in kidney transplantation (KTX). <b><i>Methods:</i></b> This was a longitudinal retrospective cohort study conducted adult KTX recipients. Patients were grouped based on receiving following KTX. Safety comparisons made between thiazide recipients unexposed patients, well change blood pressure (BP) within patients....
Integration of pharmacists into multidisciplinary transplant patient care has advanced in recent years, with limited data available to evaluate the current status profession. This was a national survey developed as an AST Pharmacy COP initiative. Responses were solicited from practicing at U.S. programs based on UNOS listing; 176 participants 113 centers (41%) responded, 79% ≤10 years. There is median 1.4 pharmacist full-time equivalents (FTEs) (range 0.1–7.1) for every 100 transplants. The...
Hepatitis C is the leading indication for liver transplantation in USA and recurrence universal. The impact of preexisting diabetes, new-onset diabetes after transplant (NODAT), glycemic control on fibrosis progression has not been studied. This retrospective longitudinal cohort study included adult recipients with hepatitis transplanted between 2000 2011. Patients were divided into three groups: (n = 41), NODAT 59), no 103). (70%) or (59%) more likely to develop (≥stage 1 fibrosis), as...
Laparoscopic cholecystectomy is the gold standard treatment for vast majority of patients with symptomatic cholelithiasis. Although cirrhotic are twice as likely to develop gallstones compared noncirrhotic patients, cirrhosis has historically been considered a relative, if not absolute, contraindication laparoscopic cholecystectomy. More recently number authors have reported on safety in patients. We reviewed our retrospectively and assessed noncirrhotics at large liver transplant center. A...