A5063303512- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Platelet Disorders and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Disease and Adiposity
- Eosinophilic Disorders and Syndromes
- Cancer Genomics and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Hippo pathway signaling and YAP/TAZ
- Blood properties and coagulation
- Cardiac Valve Diseases and Treatments
- RNA Research and Splicing
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
George Washington University
2019-2025
Platelet-like particles (PLPs), derived from megakaryocytic cell lines MEG-01 and K-562, are widely used as a surrogate to study platelet formation function. We demonstrate by RNA-Seq that PLPs transcriptionally distinct platelets. Expression of key genes in signaling pathways promoting activation/aggregation, such the PI3K/AKT, protein kinase A, phospholipase C, α-adrenergic GP6 receptor pathways, was missing or under-expressed PLPs. Functionally, do not aggregate following epinephrine,...
Abstract Platelets play a crucial role in cancer and thrombosis. However, the receptor-ligand repertoire mediating prostate (PCa) cell-platelet interactions ensuing consequences have not been fully elucidated. Microvilli emanating from plasma membrane of PCa cell lines (RC77 T/E, MDA 2b) directly contacted individual platelets platelet aggregates. were associated with calcium mobilization platelets, translocation P-selectin integrin α IIb β 3 onto surface. reciprocally promoted invasion...
Alternative splicing (AS) has been shown to participate in prostate cancer development and progression; however, a link between AS health disparities largely unexplored. Here we report on the cloning of novel splice variant FGFR3 that is preferentially expressed African American (AA) cancer. This (FGFR3-S) omits exon 14, comprising 123 nucleotides encode activation loop intracellular split kinase domain. Ectopic overexpression FGFR3-S European (EA) cell lines (PC-3 LNCaP) led enhanced...
The African American (AA) population displays a 1.6 to 3‐fold higher incidence of thrombosis and stroke mortality compared with European Americans (EAs). Current antiplatelet therapies target the ADP‐mediated signaling pathway, which significant pharmacogenetic variation for platelet reactivity. focus this study was define underlying differences in function an effort identify novel molecular targets future therapy. We performed deep coverage RNA‐Seq compare gene expression levels platelets...
<p>S1. Prostate cancer cells overexpressing FGFR3-S are resistance to the combination of dovitinib- and docetaxel-induced apoptotic activity.</p>
<p>Figure and Table legends for supplemental data.</p>
<p>S2. Common FGFR3 alterations by cancer type.</p>
<p>Figure and Table legends for supplemental data.</p>
<p>S2. Common FGFR3 alterations by cancer type.</p>
<p>S1. Prostate cancer cells overexpressing FGFR3-S are resistance to the combination of dovitinib- and docetaxel-induced apoptotic activity.</p>
<div>Abstract<p>Alternative splicing (AS) has been shown to participate in prostate cancer development and progression; however, a link between AS health disparities largely unexplored. Here we report on the cloning of novel splice variant <i>FGFR3</i> that is preferentially expressed African American (AA) cancer. This (<i>FGFR3-S</i>) omits exon 14, comprising 123 nucleotides encode activation loop intracellular split kinase domain. Ectopic overexpression...
<div>Abstract<p>Alternative splicing (AS) has been shown to participate in prostate cancer development and progression; however, a link between AS health disparities largely unexplored. Here we report on the cloning of novel splice variant <i>FGFR3</i> that is preferentially expressed African American (AA) cancer. This (<i>FGFR3-S</i>) omits exon 14, comprising 123 nucleotides encode activation loop intracellular split kinase domain. Ectopic overexpression...