A5049888989- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Medical Imaging and Pathology Studies
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immunodeficiency and Autoimmune Disorders
- Occupational and environmental lung diseases
- Protein Degradation and Inhibitors
- Sarcoidosis and Beryllium Toxicity Research
- Fibroblast Growth Factor Research
- Molecular Biology Techniques and Applications
- Diverticular Disease and Complications
- Lung Cancer Treatments and Mutations
- Infrared Thermography in Medicine
- Immune Cell Function and Interaction
- Rheumatoid Arthritis Research and Therapies
- Respiratory and Cough-Related Research
- Cancer-related gene regulation
- Monoclonal and Polyclonal Antibodies Research
- IL-33, ST2, and ILC Pathways
- Extracellular vesicles in disease
- Biomarkers in Disease Mechanisms
Royal Brompton Hospital
2013-2025
Imperial College London
2016-2025
Guy's and St Thomas' NHS Foundation Trust
2021-2024
Harefield Hospital
2024
Royal Brompton & Harefield NHS Foundation Trust
2020
KU Leuven
2019
Hôpital Louis Pradel
2019
University of Padua
2019
Lung Institute
2013-2016
Zimmer Biomet (Germany)
2014
<h3>Background</h3> A polymorphism (rs35705950) 3 kb upstream of <i>MUC5B</i>, the gene encoding Mucin 5 subtype B, has been shown to be associated with familial and sporadic idiopathic pulmonary fibrosis (IPF). We set out verify whether this variant is also a risk factor for fibrotic lung disease in other settings confirm published findings UK Caucasian IPF population. <h3>Methods</h3> healthy controls (n=416) patients (n=110), sarcoidosis (n=180) systemic sclerosis (SSc) (n=440) were...
Changes in the respiratory microbiome are associated with disease progression idiopathic pulmonary fibrosis (IPF). The role of host response to remains unknown.To explore host-microbial interactions IPF.Sixty patients diagnosed IPF were prospectively enrolled together 20 matched control subjects. Subjects underwent bronchoalveolar lavage (BAL), and peripheral whole blood was collected into PAXgene tubes for all subjects at baseline. For IPF, additional samples taken 1, 3, 6 months (if alive)...
Systemic sclerosis (scleroderma) is a life-threatening autoimmune disease that characterized by the presence of specific autoantibodies and fibrosis skin major internal organs.We genotyped polymorphism (G-945C) in promoter connective-tissue growth factor (CTGF) gene 1000 subjects two groups: group 1, consisting 200 patients with systemic 188 control subjects; 2, 300 312 subjects. The combined groups represented an estimated 10% United Kingdom. We tested effect on transcription CTGF.The GG...
Abstract Juvenile idiopathic arthritis (JIA) is the most common cause of chronic childhood disability and encompasses a number disease subgroups. In this study we have focused on systemic JIA (sJIA), which accounts for approximately 11% UK cases. This reports investigation three members IL10 gene family as candidate susceptibility loci in children with sJIA. DNA from 473 unaffected controls 172 patients sJIA was genotyped single nucleotide polymorphism (SNP) IL19 IL20 two SNPs IL10. We...
The clinical course of systemic sclerosis‐associated interstitial lung disease (SSc‐ILD) is highly variable and easily measurable biomarkers are needed to predict progression. Serum epithelial biomarker KL‐6 predictive progression measured by a decline in DL CO , regardless ILD severity, could provide increased prognostic ability inform risk stratification SSc‐ILD. See related Editorial
Cough is a commonly reported symptom in idiopathic pulmonary fibrosis (IPF) that negatively impacts patient-reported quality of life (QoL). However, both the burden cough at diagnosis and behavior over time have not been systematically described patients with IPF.
Cytokines released by infiltrating T cells may promote mechanisms leading to fibrosis in scleroderma. The aim of this study was investigate the role Th2 cytokine IL-31, and its receptor IL-31RA, scleroderma skin lung fibrosis.IL-31 measured ELISA plasma, immunochemistry fibrotic tissue patients. receptor, assayed qPCR resident cells. Next-generation sequencing used profile responses normal fibroblasts IL-31. In wild-type Balb/c mice, IL-31 administered subcutaneous mini pump, with or without...
Abstract Background and Objective The acute‐phase protein C‐reactive (CRP) is known to be associated with poor outcomes in cancer cardiovascular disease, but there limited evidence of its prognostic implications interstitial lung diseases (ILDs). We therefore set out test whether baseline serum CRP levels are mortality four different ILDs. Methods In this retrospective study, clinically measured levels, as well demographics function measures, were collected for ILD patients first presenting...
Progressive pulmonary fibrosis is the main cause of death in patients with systemic sclerosis (SSc) interstitial lung disease (ILD) and those idiopathic (IPF). Transforming growth factor-β (TGF-β) NADPH oxidase- (NOX-) derived reactive oxygen species (ROS) are drivers fibrosis. We aimed to determine role epigenetic readers, bromodomain extraterminal (BET) proteins regulation redox balance activated myofibroblasts.In TGF-β-stimulated fibroblasts, we investigated effect BET inhibitor JQ1 on...
Abstract Background and objective A proportion of patients with fibrotic hypersensitivity pneumonitis (fHP) follow a progressive disease course despite immunosuppressive treatment. Little is known about predictors mortality in fHP. We aimed to investigate the impact short‐term lung function changes fHP on mortality. Methods Baseline demographics for 145 consecutive multi‐disciplinary team diagnosis fHP, as well baseline 1‐year follow‐up function, echocardiographic findings, bronchoalveolar...
The impact of autoantibody profiles on prognosis idiopathic inflammatory myositis associated interstitial lung disease (IIM-ILD) and spectrum ILD with Myositis Specific Antibodies (MSA) remains unclear. This retrospective cohort study examines whether serological are mortality longitudinal function change.Baseline clinical/demographic characteristics follow-up consecutive adult patients IIM-ILD or Interstitial Pneumonia Autoimmune Features (IPAF) positive for MSAs were extracted from three...
To investigate free interleukin-18 (fIL-18) levels, and variation within the IL-18 system genes, in heart surgery patients, healthy men.fIL-18 was calculated from binding protein (BP) 421 men 196 post-coronary artery bypass graft (CABG) patients. After surgery, fIL-18 peaked at 6 hours (from 117 to 331 pg/mL) but fell below presurgery levels 24 (99 pg/mL), because of changes total IL-18BP. postsurgery significantly higher those who suffered a major complication after (125 versus 80 pg/mL,...
Abstract Although several genetic associations with scleroderma (SSc) are defined, very little is known on susceptibility to SSc-associated interstitial lung disease (SSc-ILD). A number of common polymorphisms have been associated SSc-ILD, but most not replicated in separate populations. Four SNPs IRF5 , and one each STAT4 CD226 IRAK1 selected as having previously the consistently were genotyped 612 SSc patients, European descent, whom 394 had ILD. The control population ( n = 503) comprised...
Abstract Background and Objective The minor T‐allele of the MUC5B promoter polymorphism rs35705950 is strongly associated with idiopathic pulmonary fibrosis (IPF). However, conflicting results have been reported on relationship between allele survival it unknown whether a specific subgroup IPF patients might benefit from carriage. We investigated association rs35705950, patient characteristics in real‐world population European patients. Methods In this retrospective study, 1751 8 centres...