A5044841484- Mental Health Research Topics
- Neural dynamics and brain function
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychosomatic Disorders and Their Treatments
- Functional Brain Connectivity Studies
- Visual perception and processing mechanisms
- Mental Health and Psychiatry
- Gambling Behavior and Treatments
- Obsessive-Compulsive Spectrum Disorders
- Neural and Behavioral Psychology Studies
- Action Observation and Synchronization
- Multisensory perception and integration
- Schizophrenia research and treatment
- EEG and Brain-Computer Interfaces
- Stalking, Cyberstalking, and Harassment
- Pain Management and Placebo Effect
- Digital Mental Health Interventions
- Musculoskeletal pain and rehabilitation
- Behavioral and Psychological Studies
- Decision-Making and Behavioral Economics
- Restraint-Related Deaths
- Motor Control and Adaptation
- User Authentication and Security Systems
- Body Image and Dysmorphia Studies
- Freedom of Expression and Defamation
Brown University
2022-2025
Allen Institute for Brain Science
2022-2025
John Brown University
2023-2024
University of Zurich
2014-2023
ETH Zurich
2014-2023
Institute for Biomedical Engineering
2014-2023
Lifespan
2023
Bernstein Center for Computational Neuroscience Munich
2011-2012
Ludwig-Maximilians-Universität München
2011-2012
University of Würzburg
2011
This paper outlines a hierarchical Bayesian framework for interoception, homeostatic/allostatic control, and meta-cognition that connects fatigue depression to the experience of chronic dyshomeostasis. Specifically, viewing interoception as inversion generative model viscerosensory inputs allows formal definition dyshomeostasis (as chronically enhanced surprise about bodily signals, or, equivalently, low evidence brain’s states) allostasis change in prior beliefs or predictions which define...
Theoretical frameworks such as predictive coding suggest that the perception of body and world – interoception exteroception involve intertwined processes inference, learning, prediction. In this framework, attention is thought to gate influence sensory information on perception. contrast exteroception, there limited evidence for purely attentional effects interoception. Here, we empirically tested if focus modulates cortical processing single heartbeats, using a newly-developed experimental...
Interoception, the perception of internal bodily states, is thought to be inextricably linked affective qualities such as anxiety. Although interoception spans sensory metacognitive processing, it not clear whether anxiety differentially related these processing levels. Here we investigated this question in domain breathing, using computational modeling and high-field (7 T) fMRI assess brain activity relating dynamic changes inspiratory resistance varying predictability. Notably, anterior...
Systematic errors in human path integration were previously associated with processing deficits the of space and time. In present work, we hypothesized that these are de facto result a system aims to optimize its performance by incorporating knowledge about prior experience into current estimate displacement. We tested linear angular displacement estimation behavior production–reproduction task under three different conditions where samples drawn from overlapping sample distributions. found...
The prediction of individual treatment responses with machine learning faces hurdles.
Abstract Quantification of magnetic resonance parameters plays an increasingly important role in clinical applications, such as the detection and classification neurodegenerative diseases. The major obstacle that remains for its widespread use routine is long scanning times. Therefore, strategies allow significant decreases scan time are highly desired. Recently, k ‐ t principal component analysis method was introduced dynamic cardiac imaging to accelerate data acquisition. This done by...
Many decisions arise through an accumulation of evidence to a terminating threshold. The process, termed bounded (or drift diffusion), provides unified account decision speed and accuracy, it is supported by neurophysiology in human animal models. In many situations, maker may not communicate immediately yet feel that at some point she had made up her mind. We hypothesized this occurs when reaches termination threshold, registered, subjectively, as "aha" moment. asked participants make...
OCD has been conceptualized as a disorder arising from dysfunctional beliefs, such overestimating threats or pathological doubts. Yet, how these beliefs lead to compulsions and obsessions remains unclear. Here, we develop computational model examine the specific that trigger sustain compulsive behavior in simple symptom-provoking scenario. Our results demonstrate single belief disturbance–a lack of confidence effectiveness one’s preventive (harm-avoiding) actions–can maintain is directly...
ABSTRACT Psychiatry faces fundamental challenges with regard to mechanistically guided differential diagnosis, as well prediction of clinical trajectories and treatment response individual patients. This has motivated the genesis two closely intertwined fields: (i) Translational Neuromodeling (TN), which develops “computational assays” for inferring patient-specific disease processes from neuroimaging, electrophysiological, behavioral data; (ii) Computational (CP), goal incorporating...
Abstract How individuals process and respond to uncertainty has important implications for cognition mental health. Here we use computational phenotyping examine individualised “uncertainty fingerprints” in relation neurometabolites trait anxiety humans. We introduce a novel categorical state-transition extension of the Hierarchical Gaussian Filter (HGF) capture implicit learning four-choice probabilistic sensorimotor reversal task by tracking beliefs about stimulus transitions. Using...
Impulsivity plays a key role in decision-making under uncertainty. It is significant contributor to problem and pathological gambling (PG). Standard assessments of impulsivity by questionnaires, however, have various limitations, partly because broad, multi-faceted concept. What remains unclear which these facets contribute shaping behavior. In the present study, we investigated as expressed setting applying computational modeling data from 47 healthy male volunteers who played realistic,...
Abstract Background Bayesian theories of perception have provided a variety alternative mechanistic explanations for autistic symptoms, including (1) overprecise sensations, (2) imprecise priors, (3) inflexible and (4) altered hierarchical learning. Here, we designed set experiments to systematically test predictions from each the four hypotheses in individuals with autism spectrum disorder (ASD). Methods Two versions two-alternative forced-choice (2AFC) random dot motion task were developed...
Perception and action are the result of an integration various sources information, such as current sensory input, prior experience, or context in which a stimulus occurs. Often, interpretation is not trivial hence needs to be learned from co-occurrence stimuli. Yet, how do we combine diverse information guide our action? Here use distance production-reproduction task investigate influence auxiliary, symbolic cues, experience on human performance under three different conditions that vary...
Summary Interoception, the perception of internal bodily states, is thought to be inextricably linked affective qualities such as anxiety. While interoception spans sensory metacognitive processing, it not clear whether anxiety differentially related these processing levels. Here we investigated this question in domain breathing, using computational modelling and high-field (7 Tesla) fMRI assess brain activity relating dynamic changes inspiratory resistance varying predictability. Notably,...
Rewards play a crucial role in sculpting all motivated behavior. Traditionally, research on reinforcement learning has centered how rewards guide and decision-making. Here, we examine the origins of themselves. Specifically, it is now well-recognized that critical reinforcing signal for food generated internally subliminally during process digestion. As such, shift our understanding as an immediate sensory gratification to state-dependent evaluation action's impact vital physiological...
Abstract Similar to many addiction disorders, pathological gambling is associated with an increased preference for immediate rewards (steep temporal discounting). In healthy participants, episodic future thinking has been shown reduce impulsivity during intertemporal choice. Here, we examine the first time a modulation of discounting via in group gamblers. We investigated sample 24 gamblers and matched controls functional magnetic resonance imaging (fMRI). Participants made choices two...
Interoception and homeostatic/allostatic control are intertwined branches of closed-loop brain-body interactions (BBI). Given their importance in mental psychosomatic disorders, establishing computational assays BBI represents a clinically important but methodologically challenging endeavor. This technical note presents novel approach, derived from generic model that underpins (meta)cognitive theories affective disorders. views homeostatic setpoints as probability distributions ("homeostatic...
Abstract Theoretical frameworks such as predictive coding suggest that the perception of body and world – interoception exteroception involve intertwined processes inference, learning, prediction. In this framework, attention is thought to gate influence sensory information on perception. contrast exteroception, there limited evidence for purely attentional effects interoception. Here, we empirically tested if focus modulates cortical processing single heartbeats, using a newly-developed...