Nonhomogeneous Poisson process (NHPP) models, frequently employed in reliability engineering, are used to estimate the number of software errors remaining a system. Traditionally, error detection rate NHPP models is usually assumed be continuous and monotonic function. The may, however, not smooth can change if testing environment, strategy or resource allocation changed. This paper describes with change-point models. Due irregularity imbedded model, classical maximum likelihood method...

Although nutrient deficiencies are thought to play roles in the development of depression, observational studies have yielded inconsistent results. This study aimed investigate whether multiple marginal associated with symptoms depression community-dwelling older Taiwanese. Data from 1371 elderly adults recruited Elderly Nutrition and Health Survey Taiwan was used this study. Depressive symptom scores on depressed mood emotions affecting daily life were derived Medical Outcomes Study Short...

Abstract Background Because of the rapid growth in elderly population, polypharmacy has become a serious public health issue worldwide. Although acute renal failure (ARF) is one negative consequence polypharmacy, association between duration and ARF remains unclear. We therefore assessed this using population-based database. Methods Data were collected from Taiwan National Health Insurance Research Database (NHIRD) 2003 through 2006. The case group included patients hospitalized for during...

Adopting social identity theory, this study examined the process linking relations between internal corporate responsibility (InCSR), work engagement, and turnover intention by focusing on mediating influence of organizational identification moderating role perceived hypocrisy. Data were obtained from 311 medical staff (excluding supervisors managers) a public regional teaching hospital in Taiwan. The results revealed that employees are more dedicated to less inclined leave firm if they...

Management of blood flow in arteriovenous fistula (AVF) is a critical clinical issue for hemodialysis (HD) patients. To determine the effect microcirculation AVF HD patients with photobiomodulation (PBM). Twenty were enrolled this study. PBM was used to radiate palm at total dose 126 J, and microcirculatory analysis investigated. Among <65 years old, there an increase 2.31% 1.37% average velocity flux AVF, respectively. This higher than those observed aged >65 old. Additionally, cumulative...

Diabetic nephropathy (DN), also known as diabetic kidney disease (DKD), is a major chronic complication of diabetes and the most frequent cause failure globally. A better understanding pathophysiology DN would lead to development novel therapeutic options. Acrolein, an α,β-unsaturated aldehyde, common dietary environmental pollutant.The role acrolein potential protective action scavengers in were investigated using high-fat diet/ streptozotocin-induced mice vitro cellular...

Recent progresses in quantitative proteomics have offered opportunities to discover plasma proteins as biomarkers for tracking the progression and understanding molecular mechanisms of uterine leiomyomas. In present study, samples were analyzed by fluorescence two-dimensional differential gel electrophoresis (2D-DIGE) differentially expressed identified matrix assisted laser desorption ionization-time flight mass spectrometry (MALDI-TOF MS). total, 20 been firmly representing 13 unique gene...

The Hyper-Geometric Distribution software reliability growth Model (HGDM) was developed to estimate the number of remaining faults after completing test/debug phase. An important problem in development process is determine when stop testing and release users. In this paper, cost optimal policy, which minimizes total expected cost, discussed. here includes penalty should be paid by manufacturer if delivered scheduled delivery time. underlying model our approach HGDM. Numerical examples are...

Considerable testing resources are required during software module testing. This paper, based on the 'hyper-geometric distribution reliability growth model' (HGDM) investigates two optimal resource allocation (OPT/RA) problems in testing: (1) minimization of number faults (NSF) still undetected system after testing, given a fixed amount resources; and (2) total required, NSF Based concepts average proportional allocation, simple methods introduced. Experimental results show that OPT/RA...

Deleted in AZoospermia-like (DAZL) is an autosomal homologue of Y chromosome-linked DAZ gene located on chromosome 3p24. DAZL only expressed the gonads and critical to germ cell development different species. However, regulation has not been explored. Reporter assays, electrophoretic mobility shift supershift assays bisulfate sequencing were used identify core promoter region DAZL. Sequence analysis was single-nucleotide polymorphisms (SNPs) region. A total 337 infertile men with abnormal...

This study assessed the feasibility of five separate machine learning (ML) classifiers for predicting disease progression in patients with pre-dialysis chronic kidney (CKD). The enrolled 858 CKD treated at a veteran's hospital Taiwan. After classification into early and advanced stages, patient demographics laboratory data were processed used to predict renal failure important features optimal prediction identified. random forest (RF) classifier synthetic minority over-sampling technique...

Chronic kidney disease (CKD) poses significant challenges to public health and healthcare systems, demanding a comprehensive understanding of its progressive nature. Prior methods have often fallen short in capturing the dynamic individual variability renal function. This study aims address this gap by introducing novel approach for individualized assessment CKD progression. A cohort 1042 patients, comprising 700 with stage 3a 342 3b 5 CKD, treated at veteran general hospital Taiwan from...

The hyper-geometric distribution software reliability growth model (HGDM) has been shown to be able estimate the number of faults initially resident in a program at beginning test-and-debug phase. A key factor HGDM is "sensitivity factor", which represents discovered and rediscovered application test instance. learning curve incorporated sensitivity generally assumed linear literature. However, this assumption apparently not realistic many applications. We propose two new factors based on...

Abstract Because children who are bullied by their peers at risk for a variety of psychosocial challenges, it is critical to better understand the nature and dynamics peer victimization. This paper defines victimization, examines forms classifies types victims, proposes model dynamic interplay among variables that serve develop maintain Findings from this review highlight cyclical problem prominent role peers, parents, school staff in

Controlled laboratory study.To measure Achilles tendon microcirculation (total hemoglobin [THb] and oxygen saturation [StO2]) before after the application of a physical agent in asymptomatic participants, to compare differences between location dosage.Tendon can be altered by superficial heating or cryotherapy.Fifty-one healthy adults (median age, 22 years; range, 20-34 years) were recruited randomly assigned into 1 4 groups. Participants each group received an intervention consisting...

The hyper-geometric distribution software-reliability growth model (HGDM) can estimate the number of initial faults in a software program. An important problem development is to determine when stop testing and then release software. This paper mainly investigates optimal policies which minimize mean total cost satisfy requirement based on HGDM. times are determined shown be finite. A numerical example illustrates these policies.

A considerable amount of testing resources is required during software module testing. In this paper, based on the HGDM (Hyper-Geometric Distribution Model) reliability growth model, we investigate following optimal resource allocation problems in testing: (1) minimization number faults still undetected system after given a total resources, and (2) repaired, Furthermore, concepts "average allocation" "proportional allocation", two simple methods are also introduced. Experimental results show...