A5010049545- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Circadian rhythm and melatonin
- Healthcare professionals’ stress and burnout
- Stress and Burnout Research
- Memory and Neural Mechanisms
- Workplace Health and Well-being
- Neural dynamics and brain function
- Ion channel regulation and function
- Neurotransmitter Receptor Influence on Behavior
Shandong University
2022-2025
Ningxia Medical University
2024
Second Hospital of Shandong University
2024
Major depression disorder (MDD) is a neuropsychiatric characterized by abnormal neuronal activity in specific brain regions. A factor that crucial maintaining normal functioning intracellular pH (pHi) homeostasis. In this study, we show chronic stress, which induces depression-like behaviors animal models, down-regulates the expression of hippocampal Na+/H+ exchanger isoform 1, NHE1, major determinant pHi neurons. Knockdown NHE1 CA1 pyramidal neurons leads to acidification, promotes...
Depression is a common psychological disease accompanied by mental disorders and somatic symptoms. However, the underlying mechanisms regarding pathogenesis of depression are still not clear. Neuronal damage resulting from inflammation considered to be one important risk factors for depression. Ginsenoside-Rg1, sterol extract extracted ginseng herbs, has been shown have neuroprotective effects against neurodegenerative diseases. Moreover, running exercise, simple behavioral therapy, recently...
Abstract Exercise is considered as playing a pivotal role in the modulation of emotional responses. However, precise circuit that mediates effects exercise on depression have yet to be elucidated. Here, molecularly defined tri‐synaptic pathway identified correlates motor inputs with antidepressant effects. With this pathway, initial from neurons within dorsal root ganglia (DRG) project excitatory gracile nucleus (GR), which turn connect 5‐HTergic raphe (DRN), eventually coursing pyramidal...
Major depressive disorder (MDD) is a common psychiatric characterized by significant mood disturbances and cognitive impairments. Chronic stress, particularly social defeat plays crucial role in the etiology of depression, with oxidative stress being pivotal factor its pathophysiology. Consequently, identifying effective strategies to mitigate prevent progression depression paramount importance. Agomelatine, an atypical antidepressant melatonergic serotonergic properties, has shown promise...
Abstract Background To explore the relationship between occupational stress, burnout and depressive symptoms among railroad workers in Fuzhou, to analyze interaction of stress on symptoms. Methods In this study, 861 railway employees Fuzhou bureau were randomly selected from January April, 2022. Occupational inventory revised edition (OSI-R), China job (CMBI) Symptom Checklist-90 (SCL-90) used investigate workers. Interactions associated with assessed by linear hierarchical regression...
Depression is a neuropsychiatric disorder characterized by persistent pleasure loss and behavioral despair. However, the potential mechanisms therapeutic targets for depression treatment remain unclear. Therefore, identifying underlying pathogenesis of would promote development novel provide effective antidepressant drugs. In this study, proteomics analysis showed that expression level phosphatase actin regulator 4 (Phactr4) was significantly increased in CA1 hippocampus depressed rats. The...