A5032190775- Lanthanide and Transition Metal Complexes
- Nanoparticle-Based Drug Delivery
- Radiopharmaceutical Chemistry and Applications
- Radioactive element chemistry and processing
- Advanced MRI Techniques and Applications
- Advanced Drug Delivery Systems
- Medical Imaging Techniques and Applications
- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Radiation Therapy and Dosimetry
- Nuclear Physics and Applications
- Nanoplatforms for cancer theranostics
- Mass Spectrometry Techniques and Applications
- Boron Compounds in Chemistry
- Advancements in Transdermal Drug Delivery
- Zebrafish Biomedical Research Applications
- Medical Imaging and Pathology Studies
- Drug Transport and Resistance Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Chemical Reactions and Isotopes
- Ginger and Zingiberaceae research
- Advanced Chemical Sensor Technologies
- Protein purification and stability
- Surfactants and Colloidal Systems
- Analytical Methods in Pharmaceuticals
University of North Carolina at Chapel Hill
2013-2024
National Alliance on Mental Illness
2024
Northwestern University
2019-2023
University of North Carolina Health Care
2022
UNC/NCSU Joint Department of Biomedical Engineering
2019
Hospital Garcia de Orta
2016-2018
University of North Carolina Hospitals
2016
University of Leicester
2014-2015
North Carolina State University
2010-2012
Burapha University
2012
"PEGylation" has become the most widely used method for imparting stealth properties to drug nanocarriers. PEGylation of nanoparticles provides a steric barrier adsorption opsonin proteins due neutrality, hydrophilicity, flexibility, and capacity hydration PEG moiety. particle surfaces can be achieved by simple or through covalent attachment activated functional groups on surface particles. molecules have also been modified enhance their uptake specific targets (e.g., tumors) achieve...
A major difficulty in treating cancer is the inability to differentiate between normal and tumor cells. The immune system differentiates from cells by T cell receptor (TCR) binding of tumor-associated peptides bound Major Histocompatibility Complex (pMHC) molecules. peptides, derived tumor-specific proteins, are presented MHC which then serve as markers. TCR a difficult protein use recombinant because production issues has poor affinity for pMHC; therefore, it not good choice identifier...
Dopamine (DA) has long been known to have modulatory effects on vertebrate motor circuits. However, the types of information encoded by supraspinal DAergic neurons and their relationship behavior remain unknown.By conducting electrophysiological recordings from awake, paralyzed zebrafish larvae that can produce behaviorally relevant activity patterns, we show generate two forms output: tonic spiking phasic bursting. Using paired DA neuron motoneuron recordings, further these firing modes are...
Objective The aim of this study was to examine and report 4 patients who developed symptomatology shortly after gadolinium-based contrast agent (GBCA) administration. Materials Methods History taking targeted physical examination were performed on subjects reported development new disease features within hours weeks having received an intravenous administration GBCA. Results Two assessed at 2 months (patient P2mo) 3 P3mo) GBCA (early stage), 7 years P7yr) 8 P8yr) (late stage). Clinical...
<i>Kaempferia parviflora</i> (KP) is an herbal plant in the family of Zingiberaceae. KP mainly contains methoxyflavones, especially 5,7-dimethoxyflavone (DMF), 5,7,4′-trimethoxyflavone (TMF), and 3,5,7,3′,4′-pentamethoxyflavone (PMF). The present study was designed to characterize pharmacokinetics, including bioavailability, distribution, excretion, identification metabolites after administration a ethanolic extract. Male rats were orally or intravenously administered 250 mg/kg concentration...
Mesoporous silica nanoparticles (MSNs) were explored as a carrier material for the stable isotope <sup>165</sup>Ho and, after neutron capture, its subsequent therapeutic radionuclide, <sup>166</sup>Ho (half-life, 26.8 h), use in radionuclide therapy of ovarian cancer metastasis. <b>Methods:</b><sup>165</sup>Ho-MSNs prepared using <sup>165</sup>Ho-acetylacetonate and MCM-41 particles, stability was determined irradiation nuclear reactor (reactor power, 1 MW; thermal flux approximately 5.5 ×...
Objectives: To optimize a lyophilization protocol for solid–lipid nanoparticles (SLNs) loaded with dexamethasone palmitate (Dex-P) and to compare the long-term stability of lyophilized SLNs aqueous SLN suspensions at two storage conditions.Materials Methods: The effect various parameters process on redispersibility was evaluated. A three month study conducted changes in particle size drug loading stored as either 4°C or 25°C/60% relative humidity (RH).Results Discussion: Of nine possible...
Antimicrobial photodynamic inactivation (PDI) is a promising therapeutic modality for the treatment of local infections. To increase efficacy PDI, chlorine e6 (Ce6) was encapsulated in cationic CTAB-liposomes composed various ratios dimyristoyl-sn-glycero-phosphatidylcholine (DMPC) and surfactant, cetyltrimethyl ammonium bromide (CTAB). The PDI liposomal-Ce6 assessed vitro against susceptible drug-resistant clinical isolates Candida albicans (C. albicans) as well infected burn wounds.Ce6 by...
The mechanism(s) of stress-induced hypoferremia and hypozincemia remains unclear. We studied the role granulocytes lactoferrin (LF) in endotoxin murine interleukin 1 (IL-1)-induced depression serum Fe Zn concentrations both rabbits rats. Both IL-1 administration induced significant (P less than 0.01) after 6 h species. Granulocyte depletion before infusion significantly diminished but not hypozincemia. Moreover, 5 or 15 mg human LF into caused 0.005) without Significant could only be...
The disposition of Witepsol H 15 suppositories radiolabelled with [99mTc] technetium hydroxymethyldiphosphonate was studied after rectal administration in volunteers. migration the radiolabel monitored continuously by external scintigraphy. resulting scintiphotos were superimposed on lower GI radiographs to determine extent spreading dosage form rectum. migrated approximately 5-7 cm into rectum nearly all studies and was, general, confined middle regions Since venous supply leads primarily...
The aim of this study was to report the use intravenous calcium (Ca)-/zinc (Zn)-diethylene triamine penta-acetic acid (DTPA) for treatment 25 symptomatic patients diagnosed with gadolinium deposition disease (GDD).Written informed consent obtained. Twenty-five (18 women; mean age, 46.8 ± 15.3 years) a diagnosis GDD were included. All had received at least 1 administration (Gd)-based contrast agent. Patients 3 sessions Ca-/Zn-DTPA, 15 treatments spaced month apart, and 10 week apart. In all...