A5068569515- Microbial Natural Products and Biosynthesis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Marine Sponges and Natural Products
- Fungal Biology and Applications
- Phytochemistry and Biological Activities
- Synthesis of Organic Compounds
- Antimicrobial Peptides and Activities
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Plant biochemistry and biosynthesis
- Plant Pathogens and Fungal Diseases
- Traditional and Medicinal Uses of Annonaceae
- Natural product bioactivities and synthesis
- Multicomponent Synthesis of Heterocycles
- Seaweed-derived Bioactive Compounds
- vaccines and immunoinformatics approaches
- Plant-Microbe Interactions and Immunity
- Signaling Pathways in Disease
- Tannin, Tannase and Anticancer Activities
- Insect Pest Control Strategies
- Phytochemistry Medicinal Plant Applications
- Phytochemical compounds biological activities
- Synthesis and Biological Activity
- Ethnobotanical and Medicinal Plants Studies
Al-Azhar University
2016-2024
Bielefeld University
2016-2023
Universidade de São Paulo
2022
Over the last decades, endophytic fungi represent a new source of pharmacologically active secondary metabolites based on underlying assumption that they live symbiotically within their plant host. In present study, fungus was isolated from Rauwolfia macrophylla, medicinal Cameroon. The showed highest homology to Curvularia sp. complete nucleotide sequence data generated internal transcribed spacer (ITS) ribosomal DNA region. Large scale fermentation, working-up and separation strain extract...
The crystal structure and unambiguous absolute configuration of meleagrin (1) isolated from fungus Emericella dentata Nq45 is reported herein to first time on the bases single X-ray diffraction. Together with 1, haenamindole (2), isorugulosuvine (3), secalonic acid D (4), ergosterol (5) cerebroside A (6) were obtained their structures determined by ESI MS NMR data analysis. Diverse biological activity was investigated. Compound 1 pronounced potent cytotoxicity against human cervix carcinoma...
Terretonin N (1), a new highly oxygenated and unique tetracyclic 6-hydroxymeroterpenoid, was isolated together with seven known compounds from the ethyl acetate extract of solid-state fermented culture Nocardiopsis sp. Their structures were elucidated by spectroscopic analysis. The structure absolute configuration 1 unambiguously determined X-ray crystallography. isolation taxonomic characterization is reported. antimicrobial activity cytotoxicity strain compound studied using different...
A series of aryl-substituted 3-amino-1-aryl-8-methoxy-1 H -benzo[ f ]chromene-2-carbonitriles (4a–4q) were designed and synthesized via reaction 6-methoxy-2-naphthol with a mixture appropriate aromatic aldehydes malononitrile under microwave conditions. The structures the novel compounds 4b, 4c, 4f, 4g, 4i, 4l, 4m, 4o–4q established according to IR, 1 H-NMR, 13 C-NMR/ C-NMR-DEPT, MS. benzochromene derivative 4c single chlorine at meta position phenyl ring and, lesser extent, other...
This work aimed to synthesize a new antihyperglycemic thiazolidinedione based on the spectral data. The DFT\B3LYP\6-311G** level of theory was used investigate frontier molecular orbitals (FMOs), chemical reactivity and map electrostatic potentials (MEPs) explain how synthesized compounds interacted with receptor. docking simulations into active sites PPAR-γ α-amylase were performed. in vitro potency these via radical scavenging evaluated. data revealed that (4-6) have higher than reference...
The anticancer, antimicrobial, and insecticidal activities of sarcotrocheliol (1) cholesterol (2) obtained from the soft coral Sarcophyton trocheliophorum (S. trocheliophorum) were intensively studied. According to this study, both compounds 1 2 showed potential cytotoxicity towards human colorectal carcinomaHCT-116 (IC50 10.4, 11.8 µg/mL) liver carcinoma HepG2 cell lines 8.8, 12.0 µg/mL), respectively. Compounds evaluated as inhibitors caspase-3, a member cysteine protease family, which is...
Isoshamixanthone (1), a new stereoisomeric pyrano xanthone together with the previously known fungal metabolites, epiisoshamixanthone (2), sterigmatocystin (3), arugosin C (4), norlichexanthone (5), diorcinol (6), ergosterol and methyllinoleate, were obtained from endophytic strain Aspergillus sp. ASCLA isolated leaf tissues of medicinal plant Callistemon subulatus. The chemical structure (1) was elucidated by extensive 1D, 2D NMR, ESI HR mass measurements, comparison literature data....
Terretonin O (1), a new meroterpenoid, was isolated individually from both methanolic extracts of thermophilic Aspergillus terreus TM8 and marine LGO13. The recently reported terretonins M (2) N (3) were further the fungus LGO13 along with nine known compounds, terrelumamide A (4), terrein (5), methyl-3,4,5-trimethoxyl-2-[2-(nicotinamide)benzamido] benzoate (6), butyrolactones I-III (7–9), aspulvinone (10), ergosterol, ergost-4-ene-3-one methyl linoleate. Structure terretonin (1) established...
Abstract In the course of our screening program for new bioactive compounds, a naturally 18-membered macrolide antibiotic, N -acetylborrelidin B ( 1 ) along with borrelidin 2 were obtained from marine Streptomyces mutabilis sp. MII. The strain was isolated sediment sample collected in Red Sea at Hurghada Coast and characterized taxonomically. Additional nine diverse compounds reported: 6-prenyl-indole-3-acetonitrile 3 ), sitosteryl-3 β - d -glucoside, campesterol, ferulic acid, linoleic acid...
Abstract During our search for novel bioactive compounds from extremophilic actinomycetes, the new Streptomyces griseorubens sp. ASMR4 was isolated a soft coral collected in Red Sea at Hurghada coast, Egypt, and characterized taxonomically. It fermented on large scale using modified solid rice medium as first example actinomycetes so far. Work-up purification of strain extract different chromatographic techniques afforded oxaphenalene derivative,...
This study deals with the ecology, phytochemistry, and biological activity investigation of Euphorbia retusa, belonging to Euphorbiaceae family, obtained from Egypt. Ecologically, retusa secretes white sap inhibiting growth other species, so is forming complete patches. Phytochemical plant was visualized intensively based on its extraction a protic organic solvent, working up purifying entire bioactive compounds using series different chromatographic techniques. A broad range diverse were...
In this study, the crude extract and its isolated compounds from stem bark of Annickia chlorantha were tested for their larvicidal, developmental, repellent activity against mosquito vector, Culex pipiens, besides toxicity to non-target aquatic organism, zebrafish (Danio rerio). The acute larvicidal compounds; namely, palmatine, jatrorrhizine, columbamine, β-sitosterol, methanolic (AC), was observed. Developmentally, larval duration significantly prolonged when palmatine β-sitosterol...
During our continual searching programme for novel bioactive metabolites from Sarcophyton trocheliophorum, collected Red Sea, we describe herein the isolation and structural elucidation of further two new pyrane-based cembranoid diterpenes: 9-hydroxy-7,8-dehydro-sarcotrocheliol (1) 8,9-expoy-sarcotrocheliol acetate (2), along with well-known sarcotrocheliol (3), (+)-sarcophine (4), (+)-sarcophytoxide (5) (-)-sarcophytoxide (6). The chemical structures compounds 1 2 were determined on basis...
A re-cultivation of the thermophilic fungus Aspergillus terreus TM8, and working up its extract afforded dichloro-benzophenone derivative, dihydrogeodin (1) in addition to butyrolactones I (2), V (3) VI (4). literature surveying revealed one recent structural assignment trial for (1), however, with some inaccuracies. We report herein a full using extensive study 1D, 2D NMR ESI HR mass data. For first time as well, we planar structure 1 X-ray crystallography. Docking molecular dynamic...
Herein, we report the isolation and stereo-structure of rare pyrane-based cembranoid diterpenes, 9-hydroxy-7,8-dehydro-sarcotrocheliol (1) sarcotrocheliol (2), from Sarcophyton trocheliophorum collected Red Sea. Absolute configurations both compounds were revised based on single crystal X-ray analyses.
Abstract The marine Iotrochoto purpurea derived Streptomyces sp. IOPU produced ten diverse bioactive compounds: hexahydro‐menaquinone MK‐9 ( 1 ), borrelidin 2 ferulic acid 3 N‐acetylanthranilic 4 uracil 5 uridine 6 ) , thymidine 7 sitosteryl‐3 β ‐D‐glucoside, linoleic and methyl linoleate. Structures of the obtained compounds were assigned by NMR mass spectrometric means. cytotoxic antimicrobial activities extract visualized against KB‐3‐1 KB‐V1 cell lines, a set microorganisms. Borrelidin...
Abstract Owing to its high interest as prolific source of diverse bioactive compounds referred in our previous research work, we have scaled-up the fermentation marine Aspergillus terreus LGO13 on a liquid culture medium isolate and identify very minor/further promising secondary metabolites study their antibacterial, cytotoxic, antiviral properties. Twenty-three known metabolites, including recently discovered microbial natural product N -benzoyl-tryptophan ( 1 ), were obtained herein....