A5019446903- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Lipid Membrane Structure and Behavior
- Analytical Methods in Pharmaceuticals
- Graphene and Nanomaterials Applications
- Bacterial Infections and Vaccines
- Estrogen and related hormone effects
- Bacteriophages and microbial interactions
- Dendrimers and Hyperbranched Polymers
- Electrospun Nanofibers in Biomedical Applications
- HER2/EGFR in Cancer Research
- Carbon Nanotubes in Composites
- Hydrogels: synthesis, properties, applications
- biodegradable polymer synthesis and properties
- RNA Interference and Gene Delivery
- Cell death mechanisms and regulation
- Polymer Nanocomposite Synthesis and Irradiation
- Inflammatory mediators and NSAID effects
- Endodontics and Root Canal Treatments
- Medical and Biological Ozone Research
- Diabetes Treatment and Management
- Pharmacological Effects and Assays
- Urinary Bladder and Prostate Research
Ankara University
2016-2025
Context: The inhibitors of cyclooxygenase (COX)-2 play an important role in cancer chemoprevention. Certain COX-2 exert antiproliferative and pro-apoptotic effects on cells.Objective: In this study, meloxicam, which is enolic acid-type preferential inhibitor, was encapsulated poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) to maintain local high concentration, its efficacy determined.Methods: NPs were prepared by using salting-out emulsion-evaporation steps. Meloxicam-loaded NP...
Bu çalışmanın amacı, çözücü buharlaştırma yöntemi ile poli (DL-laktid-ko-glikolid) (PLGA) nanopartiküllerinin hazırlanması ve bu nanopartiküllerin özellikleri üzerine çeşitli stabilizasyon ajanlarının etkilerinin aydınlatılmasıdır. Stabilizasyon kullanılması, nanopartikül üretim işlemi sırasında stabil emülsiyonların elde edilebilmesi için gereklidir. ajanının tipi oranı, final ürünün partikül boyutu üzerinde çok etkilidir. Polivinil alkol (PVA) Pluronik polimerleri PLGA üretiminde yaygın...
The objective of this research was to develop microsphere-based once-daily modified release tablet formulations diltiazem hydrochloride (DH), a potent calcium channel blocker used in angina pectoris. For purpose, DH-loaded microspheres were prepared by the solvent evaporation technique using Eudragit RS 100. effect variation drug/polymer ratio on physical and characteristics investigated. After selection suitable microspheres, tablets compressed Compritol 888 ATO, Ludipress Cellactose 80 as...
ABSTRACT Fulvestrant is used for the treatment of hormone receptor‐positive metastatic breast cancer in postmenopausal women with disease progression following anti‐estrogen therapy. Several reversed‐phase columns variable silica materials, diameters, lengths, etc., were tested optimization study. A good chromatographic separation was achieved using a Waters X‐Terra RP 18 column (250 × 4.6 mm i.d. 5 µm) and mobile phase, consisting mixture acetonitrile–water (65:35; v/v) containing...
Dermal application of various active substances is widely preferred for topical or systemic delivery. SLNs consist biocompatible and non-toxic lipids have a great potential in drugs. In this study, semisolid SLN formulations were successfully prepared by novel one-step production method as delivery system etofenamate, an anti-inflammatory drug. Compritol 888 ATO Precirol 5 chosen lipid materials the fabrication formulations. In-vitro evaluation was performed terms encapsulation efficiency,...