A5033561415- Atrial Fibrillation Management and Outcomes
- Galectins and Cancer Biology
- Cancer Cells and Metastasis
- Cardiac Valve Diseases and Treatments
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Immune Cell Function and Interaction
- Cardiac electrophysiology and arrhythmias
- Vitamin D Research Studies
- Cell Adhesion Molecules Research
- Advanced Drug Delivery Systems
- Cardiac Arrhythmias and Treatments
- Immunotherapy and Immune Responses
- Asthma and respiratory diseases
- Infective Endocarditis Diagnosis and Management
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Autoimmune and Inflammatory Disorders Research
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Cardiovascular Disease and Adiposity
- Vitamin C and Antioxidants Research
- Cardiac and Coronary Surgery Techniques
Hacettepe University
2010-2023
Trakya University
2023
Dokuz Eylül Üniversitesi Hastanesi
2023
Sağlık Bilimleri Üniversitesi
2023
Hacettepe University Hospital
2006-2021
Cancer Institute (WIA)
2015
Scientific and Technological Research Council of Turkey
2011
Middle East Technical University
2005
Radiation Oncology Institute
2005
The in silico design of tetraradical S1 states was validated experimentally through synthesis, followed by characterization including phosphorescence measurements, use trap molecules, and cell culture studies, leading to a series orthogonal dimers Bodipy chromophores with remarkable singlet oxygen efficiencies (see picture). A new path for the rational development efficient photosensitizers is thus revealed.
Abstract Fibroblasts turn into cancer associated fibroblasts (CAFs) in the tumour microenvironment. CAFs have recently attracted attention for their function as a regulator of immune cell recruitment and addition to tumour-promoting roles. In this study, we aimed determine role on monocyte macrophage polarization breast cancer. CAFs, which were α-SMA expressing contrast normal (NFs), effectively recruited monocytes. Recruitment monocytes by might be mediated chemotactic protein-1 (MCP-1)...
We introduce a novel class of water soluble, extended conjugation boradiazaindacene dyes which are efficient singlet oxygen generators and have spectacular photoinduced cytotoxicity when excited in the "therapeutic window" electromagnetic spectrum.
A series of water-soluble green perylenediimide (PDI) dyes have been synthesized. On red light excitation, these were shown to be efficient generators singlet oxygen, and in cell culture media, they display significant light-induced cytotoxic effects on the human erythroleukemia line (K-562). It appears that highly versatile PDI are likely find new applications photodynamic therapy.
Left atrial (LA) interstitial fibrosis is known to have a role in the initiation and maintenance of fibrillation (AF). The galectin-3 pathogenesis cardiac has been demonstrated previous studies. We aimed determine whether serum level associated with markers remodeling, including extent LA detected by delayed enhancement magnetic resonance imaging (DE-MRI) electromechanical delay (AEMD) paroxysmal AF patients preserved left ventricular (LV) functions.Thirty-three (58 [28-74] years, 51.5%...
Das rechnergestützte Design tetraradikalischer S1-Zustände wurde experimentell durch Synthese und anschließende Charakterisierung einschließlich Phosphoreszenzmessungen, Gebrauch von Einfangmolekülen Zellkultur-Untersuchungen bestätigt. Dies führte zu einer Reihe orthogonaler Bodipy-Chromophor-Dimere mit bemerkenswerten Singulett-Sauerstoff-Effizienzen (siehe Bild). Ein neuer Weg für die rationale Entwicklung effizienter Photosensibilisatoren wird somit vorgestellt. Detailed facts of...
Circulating fibrocytes were reported to represent a novel myeloid-derived suppressor cell (MDSC) subset and they also proposed be involved in the tumor immune escape. This fibrocyte had surface phenotype resembling non-monocytic MDSCs (CD14−CD11chiCD123−) exhibited immunomodulatory roles. Most effector functions of (circulating fibroblast-progenitors) are accomplished as tissue fibroblasts, likewise microenvironment. Therefore, fibroblasts at tissues should evaluated whether display similar...
Context: The inhibitors of cyclooxygenase (COX)-2 play an important role in cancer chemoprevention. Certain COX-2 exert antiproliferative and pro-apoptotic effects on cells.Objective: In this study, meloxicam, which is enolic acid-type preferential inhibitor, was encapsulated poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) to maintain local high concentration, its efficacy determined.Methods: NPs were prepared by using salting-out emulsion-evaporation steps. Meloxicam-loaded NP...
To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular growth factor receptor-3 (VEGFR-3) and CD44 genes relationship between their clinicopathological parameters in gastric cancer.Tissue samples were obtained from 33 patients (8 females) with cancer. mRNA LYVE-1, VEGFR-3 normal tumor tissues quantitatively measured using real time polymerase chain reaction. The results correlated lymph node metastasis, histological type differentiation...
This study compared the smear layer removing capability and cytotoxicity of NaOCl, EDTA Oxidative Potential Water (OPW). Fifteen extracted single-rooted human upper incisors were examined in three groups. The root canals enlarged to apical foramen with K files size #60 irrigated : (a) NaOCl followed by OPW, (b) OPW during after instrumentation (c) NaOCl. effect these irrigants on was evaluated using a scanning electron microscope. In vitro MTT colorimetric assay. We found that combination as...
Atrial fibrosis has been found to be associated with recurrent atrial fibrillation (AF) following catheter ablation. Autoantibodies against M2-muscarinic receptors (anti-M2-R) may play a role in the development of AF by inducing left (LA) fibrosis. In this study, we aim compare anti-M2-R levels between paroxysmal lone patients and healthy control subjects investigate relationship pre-ablation level, LA quantified delayed enhancement magnetic resonance imaging (DE-MRI), recurrence...
The hereditary hemochromatosis gene HFE plays a pivotal role in iron homeostasis. association between cancer and hetero- or homozygosity has previously been shown including hepatocellular nonhepatocellular malignancies. This study was performed to compare frequencies of C282Y H63D variants Turkish women with breast healthy controls.Archived DNA samples Hacettepe University Oncology Institute were used this study. investigated by PCR-RFLP.All subjects studied free from mutation. Thirty-nine...
Abstract: Host cells are protected from the lytic effect of complement system by regulatory proteins. This study was designed to investigate expression proteins on leukemic blasts which may be susceptible effects in circulation. The surface expressions proteins, receptor 1 (CR1, CD35), decay accelerating factor (DAF, CD55), and homologous restriction 20 (HRF20, CD59), peripheral blood bone marrow were evaluated using flow cytometry 16 acute myeloblastic leukemia (AML), lymphoblastic (ALL), 4...
The aim of this study was to comparatively investigate the effects 5-azacytidine-C (5-Aza), trichostatin-A (TSA), and all-trans retinoic acid (ATRA) on mRNA expressions Na/I symporter (NIS), thyroglobulin (Tg), thyroid peroxidase (TPO), stimulating hormone receptor (TSH-R), radioiodine (RAI) uptake in cancer (B-CPAP) normal (Nthy-ori 3-1) cell lines. Cell lines were treated with 10 ng/mL TSA, 5 μM 5-Aza, 1 ATRA, according MTT (methyl-thiazol-tetrazolium) test results. Additionally,...