A5060728886- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Photodynamic Therapy Research Studies
- Cancer-related molecular mechanisms research
- Luminescence and Fluorescent Materials
- Metabolism, Diabetes, and Cancer
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
- Cytokine Signaling Pathways and Interactions
- Graphene and Nanomaterials Applications
- Cancer Cells and Metastasis
- Nanoparticle-Based Drug Delivery
- Carbon and Quantum Dots Applications
- Epigenetics and DNA Methylation
- Protein Interaction Studies and Fluorescence Analysis
- TGF-β signaling in diseases
- PI3K/AKT/mTOR signaling in cancer
- Pancreatic function and diabetes
- Phosphodiesterase function and regulation
MUSC Hollings Cancer Center
2023-2025
Medical University of South Carolina
2023-2025
Hacettepe University
2018-2024
Hacettepe University Hospital
2019-2024
Abstract Fibroblasts turn into cancer associated fibroblasts (CAFs) in the tumour microenvironment. CAFs have recently attracted attention for their function as a regulator of immune cell recruitment and addition to tumour-promoting roles. In this study, we aimed determine role on monocyte macrophage polarization breast cancer. CAFs, which were α-SMA expressing contrast normal (NFs), effectively recruited monocytes. Recruitment monocytes by might be mediated chemotactic protein-1 (MCP-1)...
Trastuzumab emtansine (T-DM1) was the first and one of most successful antibody-drug conjugates (ADC) approved for treating refractory HER2-positive breast cancer. Despite its initial clinical efficacy, resistance is unfortunately common, necessitating approaches to improve response. Here, we found that in sensitive cells, T-DM1 induced spindle assembly checkpoint (SAC)-dependent immunogenic cell death (ICD), an immune-priming form death. The payload mediated ICD by inducing eIF2α...
Abstract Tamoxifen has been the mainstay therapy to treat early, locally advanced, and metastatic estrogen receptor-positive (ER + ) breast cancer, constituting around 75% of all cases. However, emergence resistance is common, necessitating identification novel therapeutic targets. Here, we demonstrated that long-noncoding RNA LINC00152 confers tamoxifen by blocking tamoxifen-induced ferroptosis, an iron-mediated cell death. Mechanistically, inhibiting reduces mRNA stability...
Singlet oxygen, which is stored in the form of an endoperoxide, released under hypoxic conditions typically prevalent most tumors.
Nanotheranostic tailor-made carriers are potent platforms for the treatment of cancer that propound a number advantages over conventional agents photodynamic therapy (PDT). Herein, four new heavy atom free amphiphilic glucose-BODIPY-fullerene dyads (14-17) endowed with carbohydrate units in styryl units, which can also form nanomicelles (14-17NM) Tween 80 PDT reported. Glucose-BODIPY-fullerene systems and related have been prepared to emcee efficient singlet oxygen generation upon light...
Abstract Two red‐absorbing, water‐soluble and mitochondria (MT)‐targeting selenophene‐substituted BODIPY‐based photosensitizers (PSs) were realized ( BOD − Se , I ), their potential as photodynamic therapy (PDT) agents evaluated. showed higher 1 O 2 generation yield thanks to the enhanced heavy‐atom effect, this derivative was further tested in detail cell culture studies under both normoxic hypoxic conditions. not only effectively functioned conditions, but also highly selective...
The properties of graphene oxide (GO) have received much attention and been applied to the exploration potential applications in disease-related diagnostics non-invasive therapy. One application, photodynamic therapy (PDT), involves killing cancer cells where singlet oxygen is generated with light irradiation appropriate wavelength. In this work, three new BODIPY derivatives (13-15), decorated carbohydrate moieties for active targeting branched ethylene glycol biocompatibility, their GO...
Abstract Centrosome amplification (CA) is highly prevalent in cancer. It strongly associated with tumor progression and worse prognosis a variety of different cancers. Preclinical studies have demonstrated that CA can trigger initiation as well cancer cell invasion. Thus, known to be promising therapeutic target. We previously identified Transforming Acidic Coiled-Coil Containing Protein 3 (TACC3) being overexpressed tumors CA. TACC3 forms distinct functional interactomes regulating spindle...
Abstract Phosphodiesterase 4D (PDE4D) is a member of the phosphodiesterase family enzymes, catalyzing hydrolysis cAMP second messenger and inhibiting signaling. Targeting PDE4D raises intracellular levels, leading to apoptosis cell cycle arrest in different tumor types. However, its contribution drug resistance metastasis still elusive. lncRNAs are more than 200 nucleotides length carry out diverse functions including transcriptional regulation, regulation proteins or RNA molecules by direct...
Three multifunctional targeted NI-BODIPYs (10-12) and GO-(10-12) nanocarriers were fabricated. are designed to facilitate non-covalent interaction with graphene oxide (GO) target toward cancer cells for specific recognition glucose moieties while efficiently producing singlet oxygen. We probed detailed characterization, fundamental photophysical/photochemical properties, interactions GO of such triplet photosensitizers nanocarriers. The effect the formation nanohybrids on oxygen as well...
Abstract Background Intriguingly, liver regeneration after injury does not induce uncontrolled growth and the underlying mechanisms of such a “ hepatostat ” are still clear. Endocan, proteoglycan, was implicated in regeneration. It can support function hepatocyte factor/scatter factor tissue repair injury. Endostatin, 20 kDa C-terminal fragment collagen XVIII, may modulate cessation eEF2K, protein kinase that regulates synthesis, regulate angiogenesis. Thus, we investigated role endocan,...
Abstract Objective AMP-activated-protein-kinase (AMPK) regulates cellular energy-homeostasis. Eukaryotic-elongation-factor-2-kinase (eEF2K) plays important roles in regulating protein-synthesis, functions similarly to AMPK protect cancer-cells from metabolic stress. Tumor-hypoxia induces angiogenesis with activation of hypoxia-inducible-factor-1-alpha (HIF-1α). might be implicated both regulation protein-translation and response-to-hypoxia. We aimed investigate the effects modulation on...
Angiogenesis is indeed a vital process in the progression of carcinomas, including that larynx. Therefore, this study (AngLaC) aimed to identify candidate angiogenesis-related biomarkers laryngeal carcinoma patients.Prospective controlled cohort study.Tertiary referral center.In silico analyses genes were performed determine biomarkers. Serum levels determined via enzyme-linked immunosorbent assay patients as well an age and gender-matched control group. The associations with clinical...
<b><i>Introduction:</i></b> Uveal melanoma (UM) responds poorly to targeted therapies or immune checkpoint inhibitors. Adenosine monophosphate-activated protein kinase (AMPK) is a pivotal serine/threonine that coordinates vital processes such as cell growth. Targeting AMPK pathway, which represents critical mechanism mediating the survival of UM cells, may prove be novel treatment strategy for UM. We aimed demonstrate effects modulation on cells....
Abstract Immunogenic cell death (ICD), an immune-priming form of death, has been shown to be induced by several different anti-cancer therapies. Despite being the first and one most successful antibody-drug conjugates (ADCs) approved for refractory HER2-positive breast cancer, little is known if response resistance trastuzumab emtansine (T-DM1) involves ICD modulation that can leveraged enhance T-DM1 response. Here, we report induces spindle assembly checkpoint (SAC)-dependent in sensitive...
Abstract Tamoxifen has been the mainstay therapy to treat early, locally advanced, and metastatic estrogen receptor-positive (ER+) breast cancer, constituting around 75% of all cases. However, emergence resistance is common, necessitating identification novel therapeutic targets. Here, we demonstrated that long-noncoding RNA LINC00152 confers tamoxifen via blocking tamoxifen-induced ferroptosis, an iron-mediated cell death. Mechanistically, inhibiting reduces mRNA stability phosphodiesterase...
Abstract Immunogenic cell death (ICD) is a specific form of that characterized by the release danger-associated molecular patterns (DAMPs), such as surface exposure calreticulin, ATP and HMGB1 release, can be induced several different anti-cancer therapies. This, in turn, evokes strong anti-tumor immune response, leading to reduced tumor growth. Despite being first one most successful antibody-drug conjugates (ADCs) approved for refractory HER2-positive breast cancer, little known if...
<div>Abstract<p>Trastuzumab emtansine (T-DM1) was the first and one of most successful antibody–drug conjugates (ADC) approved for treating refractory HER2-positive breast cancer. Despite its initial clinical efficacy, resistance is unfortunately common, necessitating approaches to improve response. Here, we found that in sensitive cells, T-DM1 induced spindle assembly checkpoint (SAC)-dependent immunogenic cell death (ICD), an immune-priming form death. The payload mediated ICD...