A5103240464- Advanced materials and composites
- Advanced ceramic materials synthesis
- Aluminum Alloys Composites Properties
- High Entropy Alloys Studies
- Additive Manufacturing Materials and Processes
- Metal and Thin Film Mechanics
- High-Temperature Coating Behaviors
- Orthopaedic implants and arthroplasty
- Powder Metallurgy Techniques and Materials
- Intermetallics and Advanced Alloy Properties
- Cancer Treatment and Pharmacology
- Carbon Nanotubes in Composites
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Diamond and Carbon-based Materials Research
- Advanced machining processes and optimization
- Advanced Welding Techniques Analysis
- Ion-surface interactions and analysis
- PI3K/AKT/mTOR signaling in cancer
- Graphene research and applications
- MXene and MAX Phase Materials
- Advanced Surface Polishing Techniques
- Welding Techniques and Residual Stresses
- RNA and protein synthesis mechanisms
- Catalytic Processes in Materials Science
Jiangsu Maritime Institute
2014-2025
Nanjing University of Aeronautics and Astronautics
2013-2023
Taizhou University
2011-2019
Stony Brook University
2008-2012
State University of New York
2005-2012
Brookhaven National Laboratory
2008-2010
Albert Einstein College of Medicine
2008
A novel single-walled carbon nanotube (SWNT)-based tumor-targeted drug delivery system (DDS) has been developed, which consists of a functionalized SWNT linked to tumor-targeting modules as well prodrug modules. There are three key features this nanoscale DDS: (a) use SWNTs biocompatible platform for the therapeutic drugs or diagnostics, (b) conjugation an anticancer agent (taxoid with cleavable linker) that is activated its cytotoxic form inside tumor cells upon internalization and in situ...
An efficient mechanism-based tumor-targeting drug delivery system, based on tumor-specific vitamin-receptor mediated endocytosis, has been developed. The system is a conjugate of molecule (biotin: vitamin H or B-7), self-immolative linker and second-generation taxoid (SB-T-1214) as the cytotoxic agent. This (1) designed to be (i) specific receptors overexpressed tumor cell surface (ii) internalized efficiently through receptor-mediated followed by smooth release via glutathione-triggered...
Soil erosion on the slope is a major problem in northern region of Pakistan, causing hill instability and landslides. Previous research focused assessment soil hilly regions caused by intense flooding. However, there still gap investigating impact vegetation patterns densities reduction region. Therefore, current fills this with an experimental investigation various for using physical model regions. Experiments were performed under diverse scenarios including two Froude numbers (Fr = 0.17...
Novel second-generation taxoids with systematic modifications at the C2, C10, and C3′N positions were synthesized their structure−activity relationships studied. A number of these exhibited exceptionally high potency against multidrug-resistant cell lines, several virtually no difference in drug-sensitive drug-resistant lines. These potent termed “third-generation taxoids”. 19 (SB-T-1214), 14g (SB-T-121303), 14i (SB-T-1213031) excellent activity paclitaxel-resistant ovarian cancer lines...
Dual leucine zipper kinase (DLK, MAP3K12) was recently identified as an essential regulator of neuronal degeneration in multiple contexts. Here we describe the generation potent and selective DLK inhibitors starting from a high-throughput screening hit. Using proposed hinge-binding interactions to infer binding mode specific design parameters optimize for CNS druglike molecules, came focus on di(pyridin-2-yl)amines because their combination desirable potency good brain penetration following...
Signaling pathways intersecting with the p21-activated kinases (PAKs) play important roles in tumorigenesis and cancer progression. By recognizing that limitations of FRAX1036 (1) were chiefly associated highly basic amine it contained, we devised a mitigation strategy to address several issues such as hERG activity. The 5-amino-1,3-dioxanyl moiety was identified an effective means reducing pKa logP simultaneously. When positioned properly within scaffold, this group conferred benefits...
USP7 is a deubiquitinase implicated in destabilizing the tumor suppressor p53, and for this reason it has gained increasing attention as potential oncology target small molecule inhibitors. Herein we describe biophysical, biochemical, computational approaches that led to identification of 4-(2-aminopyridin-3-yl)phenol compounds described by Kategaya (Nature 2017, 550, 534–538) specific inhibitors USP7. Fragment based lead discovery (FBLD) NMR combined with virtual screening re-mining...
Aberrant activation of the PI3K-Akt-mTOR signaling pathway has been observed in human tumors and tumor cell lines, indicating that these protein kinases may be attractive therapeutic targets for treating cancer. Optimization advanced lead 1 culminated discovery clinical development candidate 8h, GDC-0349, a potent selective ATP-competitive inhibitor mTOR. GDC-0349 demonstrates modulation dose-dependent efficacy mouse xenograft cancer models.
Purpose The aim of this study is to investigate the effects laser cladding process on microstructure, hardness and corrosion resistance properties high-entropy alloys (HEA). Design/methodology/approach Laser technology was used, using AlCoCrFeNiCu HEA powder as material. coatings were prepared surface 45 steel a coaxial feeding method. phase composition, layer analyzed optical microscopy (OM), X-ray diffractometer, digital microhardness tester electrochemical workstation. Findings power...
Based on the flexible adjustment of seven-wire, this study will assemble a new toughened seven-wire which is combined with common single welding wire and existing containing ductile alloy element (Ni element), microstructure properties, mechanical properties toughening mechanism seams were studied. The results show that four combinatorial mainly composed coarse proeutectoid ferrite (PF) fine acicular (AF). Among them, core inclusions induce AF nucleation growth are Al, Ti, Si, Mn-based...
Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative diseases, but it has been difficult to develop selective inhibitors against caspases. We report the discovery and characterization potent inhibitor that acts by an uncompetitive binding mode unprecedented mechanism inhibition this target class. Biochemical assays demonstrate that, while exquisitely over caspase-3 -7, compound's inhibitory activity also dependent on amino acid sequence P1' character peptide...
In situ Ti(C,N)-based cermets with white core/gray rim and black structures were synthesized from a Co–Ti–C–TiN–W system. addition, the reaction mechanism was explored. Results showed that allotropic transformation of εCo into αCo initially occurred. Then, αCo–Ti solid state to fabricate CoTi2 took place. Subsequently, Co–Ti liquid formed by peritectic CoTi2. With spreading liquid, C atoms dissolved melt, resulting in presence Co–Ti–C ternary liquid. reacted Ti yield TiC. increasing...