A5025969569- Estrogen and related hormone effects
- Advanced Adaptive Filtering Techniques
- Energy Efficient Wireless Sensor Networks
- Infant Health and Development
- Crystallization and Solubility Studies
- Chronic Lymphocytic Leukemia Research
- Drug Transport and Resistance Mechanisms
- X-ray Diffraction in Crystallography
- Melanoma and MAPK Pathways
- Pharmacogenetics and Drug Metabolism
- Indoor and Outdoor Localization Technologies
- Computational Drug Discovery Methods
- Speech and Audio Processing
- Hearing Loss and Rehabilitation
- PI3K/AKT/mTOR signaling in cancer
- HER2/EGFR in Cancer Research
- Mobile Ad Hoc Networks
- Colorectal Cancer Treatments and Studies
- Underwater Vehicles and Communication Systems
- Infant Development and Preterm Care
- Chronic Myeloid Leukemia Treatments
- Cancer Treatment and Pharmacology
- Lymphoma Diagnosis and Treatment
- Cooperative Communication and Network Coding
- Advanced Breast Cancer Therapies
Dalian Maritime University
2019-2025
Indiana University – Purdue University Indianapolis
2025
Indiana University Indianapolis
2025
United States Food and Drug Administration
2023-2024
Fuzhou University
2022-2024
Indiana University
2024
Northern Illinois University
2012-2023
National Taitung University
2021-2023
Tsinghua University
2016-2022
Shandong University
2021-2022
Bruton's tyrosine kinase (Btk) is a nonreceptor cytoplasmic involved in B-cell and myeloid cell activation, downstream of Fcγ receptors, respectively. Preclinical studies have indicated that inhibition Btk activity might offer potential therapy autoimmune diseases such as rheumatoid arthritis systemic lupus erythematosus. Here we disclose the discovery preclinical characterization potent, selective, noncovalent inhibitor currently clinical development. GDC-0853 (29) suppresses B cell-...
Intervehicle communication is a key technique of intelligent transport systems. Ad hoc networking in the vehicular environment was investigated intensively. This paper proposes new clustering for large multihop ad networks. The cluster structure determined by geographic position nodes and priorities associated with vehicle traffic information. Each elects one node as its head. size controlled predefined maximum distance between head members. Clusters are independently dynamically...
The extracellular signal-regulated kinases ERK1/2 represent an essential node within the RAS/RAF/MEK/ERK signaling cascade that is commonly activated by oncogenic mutations in BRAF or RAS upstream signaling. While targeting nodes with RAF and MEK inhibitors has proven effective clinically, resistance frequently develops through reactivation of pathway. Simultaneous multiple pathway, such as ERK, offers prospect enhanced efficacy well reduced potential for acquired resistance. Described...
Suberoylanilide hydroxamic acid (SAHA) is an inhibitor of histone deacetylases (HDACs) used for the treatment cutaneous T cell lymphoma (CTCL) and under consideration other indications. In vivo studies suggest reducing HDAC function can enhance synaptic memory, raising possibility that SAHA could have neurological benefits. We first examined impacts on in vitro using rat organotypic hippocampal brain slices. Following several days treatment, basal excitatory but not inhibitory was enhanced....
The tremendous success of stereogenic carbon compounds has never ceased to inspire researchers explore the potentials silicon compounds. Intermolecular C-H silylation thus represents most versatile and straightforward strategy construct C-Si bonds, however, its enantioselective variant been scarcely reported date. Herein we report a protocol that allows for intermolecular bond silylation, leading construction wide array acyclic Si-H under simple mild reaction conditions. Key is (1) substrate...
Regioselective carbohydroxylation and aminohydroxylation of α-olefins were developed by a photoredox catalyst pyridine N-oxide. This approach offers the catalytic direct conversion unactivated alkenes to series primary alcohols, including those bearing β-quaternary carbon centers β-amino alcohols. The regioselective difunctionalization is enabled radical addition α-olefin from N-oxy radical, which generated readily available N-oxide via catalyzed single-electron oxidation. A combination...
Endothelin-1 (ET-1) stimulation of endothelial nitric oxide synthase (eNOS) via pulmonary endothelin B (ET ) receptors and intravascular macrophage accumulation with expression inducible (iNOS) heme oxygenase-1 (HO-1) are implicated in experimental hepatopulmonary syndrome (HPS) after common bile duct ligation (CBDL). Our aim was to evaluate the role ET-1 development HPS. The time course molecular physiological changes HPS effects selective receptor antagonists vivo were assessed CBDL....
Developing new sensing technologies to obtain desired and accurate information more effectively from the limited sensor positions is one of critical challenges that scientists engineers aspire undertake in 21st century. This paper surveys applications virtual different fields, e.g., transportation, wireless communication, networks active noise control. It reviews existing methods used infer information. The techniques their application control are especially discussed.
Bruton9s tyrosine kinase (BTK) plays a critical role in the development, differentiation, and proliferation of B-lineage cells, making it an attractive target for treatment rheumatoid arthritis. The objective this study was to evaluate antiarthritis effect GDC-0834 [<i>R-N</i>-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[<i>b</i>]thiophene-2-carboxamide], potent selective BTK inhibitor, characterize...
// John C. Byrd 1 , Stephen Smith 2 Nina Wagner-Johnston 3 Jeff Sharman 4 Andy I. Chen 5 Ranjana Advani 6 Bradley Augustson 7 Paula Marlton 8 S. Renee Commerford 9 Kwame Okrah Lichuan Liu Elaine Murray Elicia Penuel Ashley F. Ward and Ian W. Flinn 10 Division of Hematology, Ohio State University Wexner Medical Center, Columbus, OH, USA Oncology, Washington, Seattle, WA, Washington University, St. Louis, MO, Willamette Valley Cancer Institute Research US Eugene, OR, Center for Hematologic...
ERK1/2 signaling can be dysregulated in cancer. GDC-0994 is an oral inhibitor of ERK1/2. A first-in-human, phase I dose escalation study was conducted patients with locally advanced or metastatic solid tumors.GDC-0994 administered once daily on a 21-day on/7-day off schedule to evaluate safety, pharmacokinetics, and preliminary signs efficacy. Patients pancreatic adenocarcinoma BRAF-mutant colorectal cancer were enrolled the expansion stage.Forty-seven six successive cohorts (50-800 mg)....
Systemic lupus erythematosus (SLE) is often associated with exaggerated B cell activation promoting plasma generation, immune-complex deposition in the kidney, renal infiltration of myeloid cells, and glomerular nephritis. Type-I IFNs amplify these autoimmune processes promote severe disease. Bruton's tyrosine kinase (Btk) inhibitors are considered novel therapies for SLE. We describe characterization a highly selective reversible Btk inhibitor, G-744. G-744 efficacious, superior to blocking...
Common bile duct ligation (CBDL) triggers a molecular cascade resulting in the hepatopulmonary syndrome (HPS). Both increased hepatic endothelin-1 (ET-1) production and pulmonary vascular ET(B) receptor expression with stimulation of endothelial nitric oxide synthase TNF-alpha mediated inducible heme oxygenase-1 intravascular macrophages occur. Whether biliary cirrhosis is unique triggering ET-1 alterations HPS unknown. We evaluated for rat prehepatic portal hypertension [partial vein...
Although Oatp1a1 (rat organic anion-transporting polypeptide 1a1) was the transporter found responsible for hepatocellular entry of enalapril (EN) into rat liver, canalicular involved excretion EN and metabolite, enalaprilat (ENA), unknown. The Eisai hyperbilirubinemic (EHBR) that lacks Mrp2 (multidrug resistance-associated protein 2) used to appraise role in [<sup>3</sup>H]EN its metabolite [<sup>3</sup>H]ENA single-pass liver preparations. total metabolic clearances hepatic extraction...
(<i>R</i>)-<i>N</i>-(3-(6-(4-(1,4-Dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[<i>b</i>]thiophene-2-carboxamide (GDC-0834) is a potent and selective inhibitor of Bruton9s tyrosine kinase (BTK), investigated as potential treatment for rheumatoid arthritis. In vitro metabolite identification studies in hepatocytes revealed predominant formation an inactive (M1) via amide hydrolysis human. The M1 appeared to be...
GDC-0834, a Bruton's tyrosine kinase inhibitor investigated as potential treatment of rheumatoid arthritis, was previously reported to be extensively metabolized by amide hydrolysis such that no measurable levels this compound were detected in human circulation after oral administration. In vitro studies liver cytosol determined GDC-0834 (<i>R</i>)-<i>N</i>-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-...
Approximately 10% of colorectal cancers harbor
Recently, lots of research has been directed towards natural language processing. However, the baby's cry, which serves as primary means communication for infants, not yet extensively explored, because it is a that can be easily understood. Since cry signals carry information about babies' wellbeing and understood by experienced parents experts to an extent, recognition analysis infant's only possible, but also profound medical societal applications. In this paper, we obtain analyze audio...