A5080620693- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- Protein Hydrolysis and Bioactive Peptides
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chemical Synthesis and Analysis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Enzyme function and inhibition
- Neuropeptides and Animal Physiology
- Renin-Angiotensin System Studies
- Chronic Myeloid Leukemia Treatments
- Drug Transport and Resistance Mechanisms
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Cancer Treatment and Pharmacology
- Radiopharmaceutical Chemistry and Applications
- Pharmacological Effects and Toxicity Studies
- Insect Resistance and Genetics
- Biosimilars and Bioanalytical Methods
- Renal Diseases and Glomerulopathies
- Histone Deacetylase Inhibitors Research
University of California, San Francisco
2021-2025
Sunrise Medical (United States)
2025
UCSF Helen Diller Family Comprehensive Cancer Center
2023-2024
Hospital Universitario 12 De Octubre
2024
Centro de Investigación Biomédica en Red de Cáncer
2024
Icahn School of Medicine at Mount Sinai
2024
University of California San Francisco Medical Center
2024
University of Washington
2023
National Cancer Institute
2023
American University of Beirut
2023
Goat antibodies to pig lung angiotensin-converting enzyme (kininase II) were conjugated microperoxidase. Rat tissue, previously incubated with non-immune goat serum, was the antibody-microperoxidase conjugate and then H2O2 3,3-diaminobenzidine. Electron microscopy revealed reaction product on plasma membrane caveolae of endothelial cells, especially those capillaries venules. These results support hypothesis that angiotensin I bradykinin are metabolized by enzymes luminal surface pulmonary cells.
Angiotensin-converting enzyme can be measured by the rate of release 3H-labelled hippurate from p-[3H]benzoylglycylglycylglycine. The product is separable substrate extraction acidified reaction mixtures with ethyl acetate. Assay results for human serum angiotensin-converting obtained within 1.5 h receipt samples. Within limits tested, assay appears to specific. However, interference hitherto unrecognized enzymes abnormal sera must ruled out.
Risks of B-cell maturation antigen (BCMA) chimeric receptor T-cell (CAR-T) therapy for patients with multiple myeloma (MM) include cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity (ICANS), cytopenias, and infections. The efficacy safety BCMA CAR-T in the geriatric setting, including complications such as falls delirium, which may be more prevalent older patients, have not been fully analyzed. We wanted to analyze among (age ≥70 at infusion) versus younger MM....
For patients with relapsed/refractory multiple myeloma a relapse after B-cell maturation antigen (BCMA)-directed chimeric receptor T-cell therapy (CAR-T), optimal salvage treatment strategies remain unclear. BCMA-directed CAR-T and bispecific antibodies (BsAbs) are now commercially available, the outcomes for retreatment approaches not well studied. We performed retrospective analysis of 68 relapsed disease to evaluate responses therapies. With median follow-up 13.5 months, overall survival...
Interfacing cells with nanomaterials such as graphene, nanowires, and carbon nanotubes is useful for the integration of cellular physiology electrical read outs. Here we show interfacing graphene sheets on surface yeast cells, leading to electromechanical coupling between cells. The are viable after interfacing. response caused by physiologically stressing exposure alcohols, which causes a change in cell volume, can be observed signal through graphene. volume leads straining sheets, forming...
Although Oatp1a1 (rat organic anion-transporting polypeptide 1a1) was the transporter found responsible for hepatocellular entry of enalapril (EN) into rat liver, canalicular involved excretion EN and metabolite, enalaprilat (ENA), unknown. The Eisai hyperbilirubinemic (EHBR) that lacks Mrp2 (multidrug resistance-associated protein 2) used to appraise role in [<sup>3</sup>H]EN its metabolite [<sup>3</sup>H]ENA single-pass liver preparations. total metabolic clearances hepatic extraction...
Regulators of G protein signaling (RGS) proteins are potent negative modulators and have been proposed as potential targets for small-molecule inhibitor development. We report a high-throughput time-resolved fluorescence resonance energy transfer screen to identify inhibitors RGS4 describe the first reversible an RGS protein. Two closely related compounds, typified by CCG-63802...
Immunoglobulin light chain amyloidosis (AL amyloidosis) involves deposition of abnormally folded chains into a wide range tissues causing organ dysfunction, including in the heart and kidney. Daratumumab, CD38-targeted antibody, has recently demonstrated efficacy producing hematologic responses previously treated disease. However, data on survival outcomes to daratumumab are lacking. Seventy-two patients with AL who received monotherapy dexamethasone were retrospectively evaluated. With...
Objective: To determine the cost-effective method of delivery, from society's perspective, in patients who have had a previous cesarean. Methods: We completed an incremental cost-effectiveness analysis trial labor relative to cesarean using computerized model for hypothetical 30-year old parturient. The incorporated data peer-reviewed studies, actual hospital costs, and utilities quantify health-related quality life. A threshold $50,000 per quality-adjusted life-years was used define...
Oatp1, the organic anion transport polypeptide, is an integral membrane protein cloned from rat liver that mediates uptake of various anions such as bromosulfophthalein (BSP) and taurocholate (TCA). Recent studies by others revealed thrombin inhibitor, CRC 220, a modified dipeptide, was transported oatp1. The present study designed to examine whether another peptide, enalapril, angiotensin–converting enzyme also substrate. Transport studied with enalapril (1 800 μmol/L, [ 3 H]enalapril) in...
An eight-sensor array coupling a chemoselective room-temperature ionic liquid (RTIL) with quartz crystal microbalance (QCM) transduction is presented in this work order to demonstrate the power of approach differentiating closely related analytes sensory devices. The underlying mechanism behind specific response was explored by (i) studying mass loading and viscoelasticity effects sensing layers, predominantly through variation damping impedance, combination which determines sensitivity;...
Patients receiving autologous chimeric antigen receptor T cell (CAR-T) therapy for multiple myeloma (MM) may require bridging (BT) before CAR-T infusion to maintain some level of disease control. Alkylators, such as cyclophosphamide (Cy), are often used in regimens, either high-intensity modified hyperCVAD (cyclophosphamide, vincristine, doxorubicin, and dexamethasone), or once-weekly KCd (carfilzomib, cyclophosphamide, dexamethasone). However, there is no consensus regarding the optimal BT...
The enzymes required to convert the prohormone angiotensin I into angiotensins II and III, secretagogues of aldosterone, are enriched in association with capillary endothelium isolated from rat adrenal cortex. Thus secretion aldosterone may be controlled, part, by processing peptides occurring within gland itself.
7531 Background: MM eventually becomes refractory to current treatments, and new therapeutic options with convenient dosing improved safety are needed enhance patient (pt) adherence, access, outcomes. ABBV-383 is a distinctive next-generation BCMA x CD3 bispecific antibody composed of 2 high-affinity BCMA-binding domains, low-affinity CD3-binding domain designed reduce cytokine release syndrome (CRS) risk, silenced Fc tail for an extended half-life allowing dosing. monotherapy has shown...