A5057155311- Cannabis and Cannabinoid Research
- Pain Mechanisms and Treatments
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Autophagy in Disease and Therapy
- Transplantation: Methods and Outcomes
- Chemokine receptors and signaling
- Neuroscience and Neuropharmacology Research
- Renin-Angiotensin System Studies
- T-cell and B-cell Immunology
- Anesthesia and Pain Management
- Cardiovascular Function and Risk Factors
- Acupuncture Treatment Research Studies
- Respiratory and Cough-Related Research
- Dietary Effects on Health
- Microscopic Colitis
- Herbal Medicine Research Studies
- Graphene and Nanomaterials Applications
Universidade Federal de Minas Gerais
2015-2025
Fondazione Humanitas per la Ricerca
2012
Abstract CCL3 is a protein of the CC chemokine family known to be important for T cell recruitment in inflammatory diseases. The aim current study was evaluate effects and putative mechanism action evasin-1, novel CCL3-binding protein, pathogenesis acute graft-versus-host disease (GVHD). GVHD induced by transplantation splenocytes from C57BL/6J B6D2F1 mice. Treatment recipient mice with evasin-1 prevented mortality associated GVHD. This correlated reduced weight loss clinical severity....
Bone marrow transplantation (BMT) is the current therapy of choice for several malignancies and severe autoimmune diseases. Graft versus host disease (GVHD) major complication associated with BMT. T lymphocytes other leukocytes migrate into target organs during GVHD, become activated mediate tissue damage. Chemokines are well known inducers leukocyte trafficking activation contribute to pathogenesis GVHD. Here, we review animal models used study GVHD role chemokines in mediating damage these...
ABSTRACT PI3Kγ is thought to mediate leukocyte migration injured tissues and may be important in the pathogenesis of various T-lymphocyte-dependent pathologies, including autoimmune inflammatory diseases. The present study evaluated relevance donor cells for acute GVHD using a model adoptive transfer splenocytes from WT or PI3Kγ−/− C57BL/6J mice B6D2F1 mice, that received showed reduced clinical signs disease, bacterial translocation, tissue injury, lethality rates. This was associated with...
ABSTRACT PAF is a potent lipid mediator involved in several manifestations of acute inflammation, including leukocyte influx, interaction with endothelium, and production inflammatory cytokines. The present study evaluated the relevance PAFR for pathogenesis GVHD using model adoptive transfer splenocytes from WT or PAFR−/− C57BL/6J to B6D2F1 mice. Mice, which received treatment antagonist, showed reduced clinical signs disease no mortality. In mice receiving splenocytes, there was deceased...
Leukotriene B4 (LTB4), a proinflammatory mediator produced by the enzyme 5-lipoxygenase (5-LO), is associated with development of many inflammatory diseases. In this study, we evaluated participation 5-LO/LTB4 axis in graft-versus-host disease (GVHD) pathogenesis transplanting 5-LO-deficient leukocytes and investigated effect pharmacologic 5-LO inhibition zileuton LTB4 CP-105,696. Mice that received allogeneic transplant showed an increase nuclear expression splenocytes, indicating...
Cannabidiol (CBD) is a highly lipidic phytocannabinoid with remarkable anti-inflammatory effects. The aim of this study was to evaluate CBD's effects and mechanisms action in the treatment mice subjected acute graft-versus-host disease (aGVHD). aGVHD induced by transplantation bone marrow cells splenocytes from C57BL-6j Balb-c mice. recipient were treated daily CBD, reduced mouse mortality decreasing inflammation injury promoting immune regulation jejunum, ileum, liver. Analysis jejunum...
Palmitoylethanolamine (PEA) is an endocannabinoid-like compound first encountered within the lipid fractions of specific foods and has intrigued researchers since 1950s due to its therapeutic effects. This survey aims explore promise held by PEA as anti-inflammatory immunomodulatory agent. The impact reverberates across diverse physiological systems, such central nervous system, gastrointestinal tract, vascular network, digestive respiratory system. Additionally, it effective in pain...
Lithothamnion muelleri (Hapalidiaceae) is a marine red alga, which member of group algae with anti-inflammatory, antitumor, and immunomodulatory properties. The present study evaluated the effects treatment extract (LM) in model acute graft-versus-host disease (GVHD), using adoptive splenocyte transfer from C57BL/6 donors into B6D2F1 recipient mice. Mice treated LM showed reduced clinical signs mortality when compared untreated LM-treated mice had tissue injury, less bacterial translocation,...
Graft versus host disease (GVHD) is an immunological disorder triggered by bone marrow transplantation that affects several organs, including the gastrointestinal tract and liver. Fullerenes their soluble forms, fullerols, are nanocomposites with a closed symmetrical structure anti-inflammatory anti-oxidant properties. The present study evaluated effects of treatment fullerol (C60(OH)18-20) in development pathogenesis GVHD murine model. Mice experimental were treated showed reduced clinical...