A5028432663- Renin-Angiotensin System Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mast cells and histamine
- Receptor Mechanisms and Signaling
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Chronic Kidney Disease and Diabetes
- Hormonal Regulation and Hypertension
- Renal Diseases and Glomerulopathies
- Pediatric Urology and Nephrology Studies
- Bone Metabolism and Diseases
- Inflammatory mediators and NSAID effects
- Dementia and Cognitive Impairment Research
- Bone health and treatments
- Vitamin K Research Studies
- Sarcoma Diagnosis and Treatment
- Microscopic Colitis
- Urinary Tract Infections Management
- Neurofibromatosis and Schwannoma Cases
- Chemokine receptors and signaling
- Selenium in Biological Systems
- Phytochemistry and Bioactive Compounds
- Kidney Stones and Urolithiasis Treatments
- Venomous Animal Envenomation and Studies
- Alzheimer's disease research and treatments
Universidade Federal de Minas Gerais
2009-2019
Faculdade de Ciências Médicas de Minas Gerais
2013-2016
Hospital das Clínicas da Universidade Federal de Minas Gerais
2011
Institut des Sciences Biologiques
2010
Abstract Activation of the renin-angiotensin (Ang) system induces inflammation via interaction between Ang II and type 1 receptor on leukocytes. The relevance new arm renin-Ang system, namely Ang-converting enzyme-2/Ang-(1–7)/Mas receptor, for inflammatory responses is not known was investigated in this study. For purpose, two experimental models were used: Ag-induced arthritis (AIA) mice adjuvant-induced (AdIA) rats. Male C57BL/6 wild-type or Mas−/− subjected to AIA treated with Ang-(1–7),...
AngII (angiotensin II), ACE I-converting enzyme) and the AT1 receptor (AngII type 1 receptor) are associated with inflammatory process microvascular dysfunction of AKI (acute kidney injury) induced by renal I/R (ischaemia/reperfusion). However, Ang-(1-7) [angiotensin-(1-7)], ACE2 enzyme 2) Mas also play a role in disease models. Therefore, present study, we have examined profile Ang-(1-7), compared them that AngII, receptor. Male Wistar rats were submitted to left nephrectomy ischaemia (45...
Angiotensin-(1–7) [Ang-(1–7)] is a biologically active heptapeptide that may counterbalance the physiological actions of angiotensin II (Ang II) within renin-angiotensin system (RAS). Here, we evaluated whether activation Mas receptor with oral agonist, AVE 0991, would have renoprotective effects in model adriamycin (ADR)-induced nephropathy. We also contributed for protective treatment AT1 blockers. ADR (10 mg/kg) induced significant renal injury and dysfunction was maximal at day 14 after...
There are few animal models of dengue infection, especially in immunocompetent mice. Here, we describe alterations found adult mice inoculated with an adapted Dengue virus (DENV-3) strain. Infection the DENV-3 caused inoculum-dependent lethality that was preceded by several hematological and biochemical changes increased dissemination, features consistent severe disease manifestation humans. IFN-γ expression after infection WT this increase IL-12 IL-18. In DENV-3-inoculated IFN-γ−/− mice,...
Renal ischemia and reperfusion (I/R) is the major cause of acute kidney injury in hospitalized patients. Mechanisms underlying reperfusion-associated include recruitment activation leukocytes release inflammatory mediators. In this study, we investigated renal effects administration AVE0991, an agonist Mas, angiotensin-(1–7) receptor, a murine model I/R. Male C57BL/6 wild-type or Mas −/− mice were subjected to 30 min bilateral 24 h reperfusion. Administration AVE0991 promoted renoprotective...
Rheumatoid arthritis (RA) is a chronic inflammatory disease that mainly targets the synovial membrane, cartilage and bone. It affects 1 % of population associated with significant morbidity increased mortality. Se an essential trace element antioxidant properties ability to modulate immune responses. Selemax ® inactive yeast ( Saccharomyces cerevisiae ) enriched organic Se. The aim present study was investigate effects administration in models antigen-induced (AIA) C57BL/6 mice,...
Background and Objective The angiotensin type 1 (AT1) receptor has been implicated in the pathogenesis of inflammatory bone disorders. This study aimed to investigate effect an AT1 antagonist infection‐induced arthritis‐associated alveolar loss mice. Material Methods Mice were subjected Aggregatibacter actinomycetemcomitans oral infection or antigen‐induced arthritis treated daily with 10 mg/kg prototype antagonist, losartan. Treatment was conducted for 30 d infectious condition 17 11...
Objective To compare the results of neuropsychological tests, evoked potentials N200 and P300 polymorphisms ApoE BDNF rs6265 between patients with normal cognition those mild cognitive impairment (MCI) Alzheimer's dementia (AD). Methods This is a cross‐sectional study elderly individuals MCI AD, who were submitted to potential tests (N200 P300) by means hearing stimuli based on auditory oddball paradigm. Genotyping was obtained using real‐time PCR technique. Results Sixty‐five evaluated as...
Rheumatoid Arthritis (RA) is a chronic disease characterized by persistent inflammation and pain. Alternative therapies to reduce these symptoms are needed. Marine algae valuable sources of diverse bioactive compounds. Lithothamnion muelleri (Hapalidiaceae) marine with anti-inflammatory, antitumor, immunomodulatory properties. Here, we investigated the potential anti-inflammatory analgesic activities L. in murine model antigen-induced arthritis (AIA) mice. Our results demonstrate that...
To characterize an experimental model of progressive renal disease induced by different degrees nephrectomy in rats.Eighty male Wistar rats were divided into four groups (n=20/group): sham surgery (control group), leading to mild uremia (group 1), moderate 2) and severe 3). Ten animals each group followed for two or weeks. At the end, blood 24-hour urine samples collected determine function parameters. Urine output water food intake daily monitored.In 1, serum levels creatinine urea...
Posterior urethral valve is the most common lower urinary tract obstruction in male children. A high percentage of patients with posterior evolve to end-stage renal disease. Previous studies showed that cytokines, chemokines, and components renin-angiotensin system contribute damage obstructive uropathies. The authors recently found urine samples from fetuses have increased levels inflammatory molecules. aim this study was measure molecules investigate their correlation previously detected...
It is still unknown how the pharmacological inhibition of Renin Angiotensin System (RAS) impacts levels inflammation and fibrosis biomarkers.This study sought to evaluate effect enalapril, candesartan aliskiren on urinary cytokines in a model chronic kidney disease (CKD).Male Wistar rats were submitted surgical removal ¾ renal parenchyma induce CKD (¾ nephrectomy), or subjected sham surgery (control). Animals then randomized into five groups: Sham receiving vehicle; Nephrectomy enalapril (10...