A5102788032- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Cardiovascular Effects of Exercise
- Antimicrobial Resistance in Staphylococcus
- 14-3-3 protein interactions
- Quinazolinone synthesis and applications
- Enzyme Structure and Function
- Wnt/β-catenin signaling in development and cancer
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Antibiotic Resistance in Bacteria
- Biochemical and Molecular Research
- Cardiovascular Function and Risk Factors
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Ubiquitin and proteasome pathways
- Monoclonal and Polyclonal Antibodies Research
University of Chinese Academy of Sciences
2023-2025
Guangzhou Institutes of Biomedicine and Health
2023-2025
State Key Laboratory of Respiratory Disease
2023-2025
Chinese Academy of Sciences
2024-2025
Second Xiangya Hospital of Central South University
2022-2024
Central South University
2022-2024
Shanghai Jiao Tong University
2023
ABSTRACT The escalating threat of mycobacterial infectious diseases, particularly those caused by nontuberculous mycobacteria (NTM), poses a serious challenge to public health. Linezolid (LZD), an oxazolidinone antimicrobial, exhibits potent activity against Mycobacterium tuberculosis and NTM. Generally, mutations in the rrl rplC genes are widely associated with resistance LZD. However, this study, we screened marinum strains lacking such mutations, indicating presence alternative mechanism....
Abstract Objectives Amikacin is crucial for treating Mycobacterium abscessus (Mab) infections, with resistance primarily attributed to rrs gene mutations. The correlation between specific mutations and amikacin susceptibility, along the associated fitness cost, requires further investigation. Methods We isolated spontaneous amikacin-resistant mutants in vitro identified their mutation sites via Sanger sequencing, which were then compared existing reports. Using CRISPR/Cas12a-assisted...
The emergence of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains poses serious challenges to global control, highlighting the urgent need elucidate mechanisms underlying multidrug resistance. In this study, we screened for spontaneous bortezomib (BTZ)-resistant smegmatis (Msm) mutants identified a strain, Msm-R1-2, exhibiting 16- 64-fold increases in minimum inhibitory concentrations (MICs) BTZ linezolid (LZD), respectively, compared parental strain....
Modulating Tankyrases (TNKS), interactions with USP25 to promote TNKS degradation, rather than inhibiting their enzymatic activities, is emerging as an alternative/specific approach inhibit the Wnt/
Mycobacterial Clp protease system has emerged as a promising therapeutic target. Numerous natural cyclic peptides, like ilamycins, have been reported to possess antitubercular activities by targeting ClpC1 component of the ClpC1P1P2 proteasome, albeit without strong genetic evidence. Here, we discovered that ilamycin E and F (ILE/F) exhibit more potent delayed mycobactericidal than other components. Novel insertion mutations in clpC1 unique mutation clpX identified. These proven cause...
A series of 2-(tetrazol-5-yl)sulfonylacetamide derivatives were synthesized and evaluated for their in vitro inhibitory activity against Mycobacterium tuberculosis (Mtb) marinum (Mm). The most active compounds exhibited MIC90 values 1.25 μg/mL Mtb, but they less effective Mm (MIC90 ≥ 10 μg/mL). Despite the having favourable physicochemical properties one them a half-life ∼3 h when incubated with mouse liver microsomes, two representative highly showed strong chemical reactivity to cysteine...
Abstract Background We applied stereotactic body radiotherapy (SBRT) for the first time in treatment of patients with hypertrophic obstructive cardiomyopathy (HOCM), and significant improvements symptoms diastolic function were observed after treatment. Objectives To evaluate impact SBRT on cardiac structure, function, clinical indicators HOCM. Methods This study included 12 drug-refractory symptomatic HOCM (6 who underwent 6 received pharmacological alone) conducted a retrospective analysis...
Objective: To explore the safety and feasibility of stereotactic radiation therapy (SBRT) strategy for irradiating porcine ventricular septum, see if can provide a preliminary experimental evidence clinical SBRT in patients with hypertrophic obstructive cardiomyopathy (HOCM). Methods: Five male pigs (39-49 kg, 6 months old) were used this study. Pigs irradiated at doses 25 Gy (n=2) or 40 (n=3). Delineation target volume was achieved under guidance 3-dimensional CT image reconstruction, then...