A5089772632- Advancements in Transdermal Drug Delivery
- Wound Healing and Treatments
- 3D Printing in Biomedical Research
- Skin Protection and Aging
- Tendon Structure and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Bee Products Chemical Analysis
- Mesenchymal stem cell research
- Optical Coherence Tomography Applications
- Surgical Sutures and Adhesives
- Ocular Surface and Contact Lens
UConn Health
2020-2024
University of Connecticut
2021-2024
University of Nebraska–Lincoln
2021
Abstract Sustained inflammation can halt or delay wound healing, and macrophages play a central role in healing. Inflammatory are responsible for the removal of pathogens, debris, neutrophils, while anti‐inflammatory stimulate various regenerative processes. Recombinant human Proteoglycan 4 (rhPRG4) is shown to modulate macrophage polarization prevent fibrosis scarring ear Here, dissolvable microneedle arrays (MNAs) carrying rhPRG4 engineered treatment skin wounds. The vitro experiments...
Microneedle arrays (MNAs) have been used for decades to deliver drugs transdermally and avoid the obstacles of other delivery routes. Hydrogels are another popular method delivering therapeutics because they provide tunable, controlled release their encapsulated payload. However, hydrogels not strong or stiff, cannot be formed into constructs that penetrate skin. Accordingly, it has so far impossible combine transdermal route provided by MNAs with therapeutic encapsulation potential...
A major impediment preventing normal wound healing is insufficient vascularization, which causes hypoxia, poor metabolic support, and dysregulated physiological responses to injury. To combat this, the delivery of angiogenic factors, such as vascular endothelial growth factor (VEGF), has been shown provide modest improvement in healing. Here, importance specialty systems explored controlling bed drug distribution consequently improving rate quality. Two intradermal systems, miniaturized...
Wound healing is the complex physiological process of restoring skin's integrity, structure, and function after damage caused by external conditions. The wound cascade may be altered due to progression certain diseases, such as diabetes, venous hypertension, or peripheral arterial disease, resulting in non-healing chronic wounds. Chronic wounds can characterized a wide variety pathologies including increased reactive oxygen species, ineffective neutrophil activity, overabundance...
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Upon injury, regenerating skin is metabolically active and requires oxygen for physiological processes related to wound healing. Such can be halted in hypoxic conditions common chronic wounds. Microneedle arrays (MNAs) have been demonstrated improve therapeutic delivery Recently, few studies explored the use of oxygen‐releasing MNAs; however, they involve complex manufacturing handling fail eliminate cytotoxic byproducts. To address these challenges, biodegradable mechanically robust gelatin...
In article number 2001800 by Nicholas A. Peppas, Indranil Sinha, Ali Tamayol, and co-workers, the effect of vascular endothelial growth factor (VEGF) delivered intradermally using liquid jet injectors miniaturized needle arrays on wound healing is investigated in mouse pig models. Miniaturized facilitate proper drug distribution within tissue improve rate quality healing.