A5064978476- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Anorectal Disease Treatments and Outcomes
- Endometriosis Research and Treatment
- Urinary Tract Infections Management
- Uterine Myomas and Treatments
- Pelvic and Acetabular Injuries
- Ureteral procedures and complications
- Urological Disorders and Treatments
- Estrogen and related hormone effects
- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- Hernia repair and management
- Pregnancy-related medical research
- Diverticular Disease and Complications
- Nutrition and Health Studies
- Menopause: Health Impacts and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Protease and Inhibitor Mechanisms
- Regulation of Appetite and Obesity
- Cancer Risks and Factors
- TGF-β signaling in diseases
- Anesthesia and Pain Management
Medical University of Lublin
2015-2024
University of Siedlce
2023
1 Military Clinical Hospital with Outpatient Clinic
2023
Jagiellonian University
2021
Colorado Center for Reproductive Medicine
2018
Yale University
2018
University of California, San Francisco
2018
Prisma Health
2018
Beneficência Portuguesa de São Paulo
2018
Universidade de São Paulo
2018
An international, multicentre, randomized double‐blind trial is presented. Patients were to treatment with tolterodine, placebo, and two doses of solifenacin. The authors concluded that the solifenacin improved urgency other symptoms overactive bladder, an acceptable level side‐effects. A further phase 3 study into effect duloxetine was undertaken assess whether previous evidence efficacy from North America Europe could be sustained in parts world. In this placebo‐controlled study, found...
To evaluate the efficacy and safety of elagolix, an oral, nonpeptide gonadotropin-releasing hormone antagonist, over 12 months in women with endometriosis-associated pain.Elaris Endometriosis (EM)-III -IV were extension studies that evaluated additional 6 treatment after two 6-month, double-blind, placebo-controlled phase 3 trials (12 continuous months) elagolix doses (150 mg once daily 200 twice daily). Coprimary endpoints proportion responders (clinically meaningful pain reduction stable...
The long-term potential of solifenacin and mirabegron combination treatment for patients with overactive bladder (OAB) has not been previously assessed. To evaluate the safety efficacy succinate 5 mg plus 50 tablets (combination treatment) versus or monotherapy in OAB over 12 mo. Randomised, double-blind, multicentre, phase 3 trial (SYNERGY II) "wet" symptoms (urinary frequency urgency incontinence) ≥3 study was conducted from March 2014 to September 2016; 1829 randomised. full analysis set...
Abstract Purpose Urogenital Distress Inventory-6 (UDI-6), Incontinence Impact Questionnaire-7 (IIQ-7) and The International Consultation on (ICIQ-SF) Short Form are used to diagnose individuals with urinary incontinence (UI) assess the impact of dysfunction patient quality life. While ICIQ-SF has fixed cutoff values—UDI-6 IIQ-7 do not. We aimed find scores for UDI-6 in women UI. Methods study involved 205 aged between 31 83 years—155 with, 50 without UI symptoms. All participants completed...
Objective: To compare the efficacy and safety of mirabegron 50 mg solifenacin 5 in overactive bladder (OAB) patients dissatisfied with previous antimuscarinic treatment due to lack efficacy. Patients methods: This randomized, double-blind, phase IIIb, noninferiority study, enrolled male female aged ⩾18 years old, symptoms OAB for ⩾3 months, who were their drug A total 1887 randomized receive ( n = 943) or 944) daily 12 weeks. The primary endpoint was change from baseline end mean number...
Dexketoprofen trometamol plus tramadol hydrochloride is a new oral combination of two analgesics, which have different mechanisms action for the treatment moderate to severe acute pain. Randomised, double-blind, parallel, placebo and active-controlled, single multiple-dose study evaluate analgesic efficacy safety dexketoprofen/tramadol 25 mg/75 mg in comparison with agents (dexketoprofen 100 mg) pain after abdominal hysterectomy. Patients received seven consecutive doses drug within 3-day...
The present study aimed to investigate the presence of T regulatory cells (Tregs) in peripheral blood (PB) and peritoneal fluid (PF) females with endometriosis. included 42 patients who underwent laparoscopy between 2010 2011. Flow cytometry was used determine percentage Tregs PF PB patients. No significant difference observed endometriosis group compared those control (9.1±5.4 vs. 9.1±3.8%) or (6.5±3.2 6.5±3.7%). However, found be higher groups, but significance only group. Furthermore, no...
Matrix metalloproteinase-2 and -9 (MMP-2 -9) are proteolytic enzymes degrading extracellular matrix proteins, mainly collagen type IV. Recent reports show that these proteases may be implicated in the growth of uterine leiomyoma. The aim present study was to evaluate activity MMP-2 MMP-9, contents their tissue inhibitors (TIMP-1 TIMP-2) immunolocalization IV leiomyoma corresponding myometrium.Material for comprised specimens leiomyomas myometrium derived from 20 hysterectomized women. MMP-9...