A5073949877- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Associations and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Spine and Intervertebral Disc Pathology
- Adipose Tissue and Metabolism
- IL-33, ST2, and ILC Pathways
- Epigenetics and DNA Methylation
- Genetic and phenotypic traits in livestock
- Lipid metabolism and disorders
- Ion Transport and Channel Regulation
- Regulation of Appetite and Obesity
- Genetic diversity and population structure
- Musculoskeletal pain and rehabilitation
- Atherosclerosis and Cardiovascular Diseases
- Protease and Inhibitor Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Inflammasome and immune disorders
- Marine Biology and Environmental Chemistry
- GDF15 and Related Biomarkers
- Cardiac Fibrosis and Remodeling
- RNA modifications and cancer
- Studies on Chitinases and Chitosanases
- Ion Channels and Receptors
- Pancreatitis Pathology and Treatment
Taipei Tzu Chi Hospital
2016-2025
Chongqing Academy of Animal Science
2021-2023
Buddhist Tzu Chi Medical Foundation
2015
Buddhist Tzu Chi General Hospital
2008-2014
Tzu Chi University
2013
Chang Gung Memorial Hospital
2003-2005
Memorial Hospital of South Bend
2005
Background Insulin resistance (IR) and the consequences of compensatory hyperinsulinemia are pathogenic factors for a set metabolic abnormalities, which contribute to development diabetes mellitus cardiovascular diseases. We compared traditional lipid levels ratios combined them with fasting plasma glucose (FPG) or adiposity status determining their efficiency as independent risk IR. Methods enrolled 511 Taiwanese individuals analysis. The clinical usefulness various parameters—such ratios;...
A general concept is introduced featuring an ideal multifunctional surface that can avoid fouling problems while allowing the installed groups to perform with high efficacy and accuracy necessary for delivering cascading spontaneous biological activities. The idea realized by using a direct synthesis of multicomponent coating containing two functionalities 4‐methyl‐propiolate 4‐ N ‐maleimidomethyl achieved via chemical vapor deposition copolymerization on various substrates. novel...
Plasma GDF15 concentrations were measured in 612 Taiwanese individuals without overt systemic disease. Clinical parameters, genetic variants, and 22 biomarker levels analyzed. We further enrolled 86 patients with PAD 481 CAD, who received endovascular intervention coronary angiography, respectively, to examine the role of level predicting all-cause mortality. Significant associations found between genotypes/haplotypes levels. The circulating was positively associated age, smoking,...
Background: The common non-synonymous mutation of the glucokinase regulator (GCKR) gene, namely rs1260326, is widely reported to have pleiotropic effects on cardio-metabolic traits and hematological parameters. Objective: This study aimed identify whether other GCKR variants may independent rs1260326 genotypes. Methods: In total, 81,097 Taiwan Biobank participants were enrolled for regional plot association studies candidate variant analysis region around gene. Results: initial approach...
PCSK9 is a candidate locus for low-density lipoprotein cholesterol (LDL-C) levels. The cause-effect relationship between LDL-C levels and diabetes mellitus (DM) has been suggested to be mechanism-specific. To identify the role of genome-wide association study (GWAS)-significant variants in risk DM by using Mendelian randomization (MR) analysis, total 75,441 Taiwan Biobank (TWB) participants was enrolled GWAS determine common rare their associations with MR studies were also conducted...
Scavenger receptor class B type I (SR-BI) is a multiligand cell-surface that mediates the selective uptake of lipid from HDL cholesterol (HDL-C) into cells. This study hypothesized an association between functional variants in promoter region SR-BI gene and HDL-C levels.We identified 2 novel mutations by using single-strand conformation polymorphism. One mutation was 11-bp CCCCGCCCCGT deletion positions -140 to -150 relative transcription start site, corresponding Sp1 binding site; other...
Abstract : An E670G polymorphism of the exon 12 proprotein convertase subtilisin/kexin type 9 ( The subjects included 202 CAD patients and 614 unrelated controls. Genotypes were determined via polymerase chain reaction, restriction mapping with Contradictory to results a previous report, significantly lower level LDL-C was noted in These indicate that Clin Chem Lab Med 2009;47:154–8.
Recent studies suggest that hyperuricemia is a potential risk factor for cardiovascular disease (CVD). Hyperuricemia highly heritable and associated with sex body weight. Previous genome-wide association have found the ABCG2 single nucleotide polymorphism (SNP) rs2231142 an important genetic increased uric acid (UA) levels, degree of between affected by both ethnicity. This investigation aimed to analyze polymorphisms UA as well their interactions obesity in Taiwanese.Two around gene were...
Chemerin, an adipokine and inflammatory mediator, is associated with metabolic, inflammation- immune-mediated diseases. The genetic, clinical, biomarker correlates of circulating chemerin levels have not been completely elucidated. We analyzed the determinants retinoic acid receptor responder 2 ( RARRES2 ; encoding chemerin) gene variants in Taiwanese population. In total, 612 individuals were recruited. Clinical metabolic phenotypes, 13 markers, 5 adipokines, 6 single-nucleotide...
Several apolipoprotein genes are located at the APOE locus on chromosome 19q13.32. This study explored genetic determinants of cardiometabolic traits and metabolic syndrome in a Taiwanese population. A total 81,387 Taiwan Biobank (TWB) participants were enrolled to undergo genotype–phenotype analysis using data from Axiom Genome-Wide CHB arrays. Regional association with conditional revealed lead single-nucleotide variations (SNVs) locus: rs7412 rs429358 for total, low-density lipoprotein...
Intervertebral disc degeneration (IVDD), for which obesity and genetics are known risk factors, is a chronic process that alters the structure function of intervertebral discs (IVD). Circulating leptin positively correlated with body weight often measured to elucidate pathogenesis IVD degeneration. In this study, we examined associations LEP single nucleotide polymorphisms (SNPs) genetic environmental effects IVDD. A total 303 Taiwanese patients IVDD (mean age, 58.6 ± 12.7 years) undergoing...
Background: Despite the widespread use of lipid-lowering agents, risk atherosclerotic cardiovascular disease (ASCVD) remains; this residual has been attributed to remnant cholesterol (RC) levels. However, causal associations between RC levels and various atherosclerosis-related cardiometabolic vascular factors for ASCVD remain unclear. Methods: Using genetic biochemical data 108,876 Taiwan Biobank study participants, follow-up 31,790 imaging 18,614 we conducted a genome-wide association...
YKL-40, a pleotropic cytokine, is emerging as risk factor and prognostic predictor of atherosclerotic cardiovascular disease. We attempted to elucidate the genetic, clinical biochemical correlates circulating YKL-40 level and, by combining it with CHI3L1 gene variants, long-term mortality peripheral artery disease (PAD). Plasma concentrations were measured in 612 Taiwanese individuals who had no clinically overt systemic Clinical parameters, promoter variants 18 biomarker levels analyzed....
Chemerin, a novel adipokine, has been associated with metabolic, inflammatory, and atherosclerotic diseases. We aimed to determine the genetic basis of chemerin levels by conducting genome-wide association study (GWAS) investigate role RARRES2 polymorphisms circulating in long-term outcome coronary artery disease (CAD). A total 2197 participants from Taiwan Biobank (TWB) were recruited for GWAS analysis, 481 patients angiographically confirmed CAD enrolled analysis. One locus significance...
Intervertebral disc (IVD) degeneration is related to numerous risk factors, including obesity. Leptin, one of the commonly measured adipokines, proven play an important role in pathogenesis IVD degeneration. In context degeneration, matrix metalloproteinase-1 (MMP-1), which upregulated and activated by leptin, most abundant catabolic enzyme. It remains unclear factors mentioned above strongly associated with degeneration.To investigate influence MMP-1 we determined strength different...
Aim: This study aims to investigate whether osteoprotegerin (OPG) or osteopontin (OPN) single nucleotide polymorphisms (SNPs) will predict survival. Materials & methods: enrolled 617 participants undergoing health examination, 536 coronary artery disease (CAD) patients and 86 peripheral (PAD) patients. Genotypes of OPG SNP rs2073618 OPN rs11730582 were determined. levels measured. Results: In both CAD PAD populations, high strong predictors all-cause death. The CC genotype the TT did not...
Abstract Background Among six extant tiger subspecies, the South China ( Panthera tigris amoyensis ) once was widely distributed but is now rarest one and extinct in wild. All living tigers are descendants of only two male four female wild-caught they survive solely zoos after 60 years effective conservation efforts. Inbreeding depression hybridization with other subspecies were believed to have occurred within small, captive population. It therefore urgently needed examine genomic landscape...
Background : The –1131T>C polymorphism in the apolipoprotein gene A5 ( APOA5 ) was found to be associated with increased levels of plasma triglyceride and decreased high-density lipoprotein cholesterol (HDL-C), which are characteristic dyslipidemic components metabolic syndrome. This study aimed identify a link between this risk Methods sample population comprised 615 unrelated subjects, 18.7% whom had Genotypes were determined via polymerase chain reaction, restriction mapping Mse I, gel...