A5002029885- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Tissue Engineering and Regenerative Medicine
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Renal and related cancers
- Transplantation: Methods and Outcomes
- Animal Disease Management and Epidemiology
- Systemic Sclerosis and Related Diseases
- Mesenchymal stem cell research
- Pharmacological Effects and Toxicity Studies
- Electrospun Nanofibers in Biomedical Applications
- Pregnancy and Medication Impact
- Complement system in diseases
- Metabolism and Genetic Disorders
- Renaissance Literature and Culture
- T-cell and Retrovirus Studies
- Cytomegalovirus and herpesvirus research
- Liver Disease and Transplantation
- Extracellular vesicles in disease
- Infectious Aortic and Vascular Conditions
- Renal cell carcinoma treatment
Azienda USL di Bologna
2021-2025
University of Bologna
2017-2022
Policlinico S.Orsola-Malpighi
2017-2021
University of Pavia
2012-2017
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2017
Policlinico San Matteo Fondazione
2012-2017
Kidney donation after circulatory death (DCD) is a less than ideal option to meet organ shortages. Hypothermic machine perfusion (HMP) with Belzer solution (BS) improves the viability of DCD kidneys, although graft clinical course remains critical. Mesenchymal stromal cells (MSC) promote tissue repair by releasing extracellular vesicles (EV). We evaluated whether delivering MSC-/MSC-derived EV during HMP protects rat kidneys from ischaemic injury and investigated underlying pathogenic...
IntroductionPost-transplant thrombotic microangiopathy (PT-TMA) is an uncommon event that characterizes approximately 3-14% of kidney transplants (KT), and associated with a higher risk delayed graft function loss. PT-TMA occurs more frequently within the first three months after transplant can be manifestation de novo disease or recurrence previous atypical hemolytic uremic syndrome (aHUS). Abnormalities in complement regulation genes could explain increased susceptibility some patients to...
ABSTRACT Background A long-standing effort is dedicated towards the identification of biomarkers allowing prediction graft outcome after kidney transplant. Extracellular vesicles (EVs) circulating in body fluids represent an attractive candidate, as their cargo mirrors originating cell and its pathophysiological status. The aim study was to investigate EV surface antigens potential predictors renal Methods We characterized 37 by flow cytometry, serum urine EVs from 58 patients who were...
We studied Mesenchymal Stromal Cells (MSC) effects in experimental Unilateral Ureteral Obstruction (UUO), a fibrogenic renal disease. Rats were divided 5 groups: sham, UUO, MSC treated-UUO, ACEi MSC+ACEi treated- UUO. Data collected at 1, 7, 21 days. UUO induced monocyte infiltration, tubular cell apoptosis, atrophy, interstitial fibrosis and overexpression of TGFβ, Renin mRNA (RENmRNA), increase Renin, Angiotensin II (AII) aldosterone serum levels. Both lisinopril (ACEi) treatment prevented...
Recurrence of IgA nephropathy (IgAN) after kidney transplant (KT) appears associated with worse graft survival; thus, the identification risk factors is worthwhile to improve pre-transplant evaluation KT recipients and identify optimal treatment strategy. The aim this study was determine incidence, impact on renal function survival IgAN recurrence KT. We performed a retrospective including 110 patients biopsy-proven IgAN, who underwent at Policlinico di Sant'Orsola Hospital - University...
Background: Acute rejection (AR) in kidney transplant (KT) recipients remains a significant challenge for short- and long-term graft survival even the most recent years characterized by extended criteria donors older more comorbid recipients. Methods: We analyzed risk factors outcomes of AR 339 KT treated at St. Orsola-Malpighi Hospital, Bologna (Italy), between 1 January 2019 31 December 2021. Demographic, immunological, data (type, cold ischemia time, complications) were recorded with...
In former studies we showed in a rat model of renal transplantation that Mesenchymal Stromal Cells (MSC) prevent acute rejection an independent way their endowing the graft. this study investigated whether MSC operate by resetting cytokine network and Scatter Factor systems, i.e. Hepatocyte Growth (HGF), Macrophage Stimulating Protein (MSP) receptors Met RON, respectively.MSC were injected into artery soon after reperfusion. Controls grafted untreated normal rats. Rats sacrificed 7 days...
Background Extended criteria donors (ECD) are widely utilized due to organ shortage, but they may increase the risk of graft dysfunction and poorer outcomes. Hypothermic oxygenated perfusion (HOPE) is a recent preservation strategy for marginal kidney liver grafts, allowing redirect from anaerobic metabolism aerobic under hypothermic conditions protecting grafts oxidative species–related damage. These mechanisms improve function survival. Objective With this study, we will evaluate benefit...
Urine-derived renal epithelial cells (URECs) are highly voided after kidney transplant and express typical markers, including markers of progenitor cells. Recently URECs have shown promising immunomodulatory properties when cultured with Peripheral Blood Mononuclear Cells (PBMCs), promoting an increase in the T regulatory In vivo, exposed to damage associated molecules during both acute chronic injury. Neutrophil gelatinase-associated lipocalin (NGAL) is one most -known early marker damage....
Abstract Background Diabetic donors are recognized as a reliable source of organs, although the discard rate kidneys is still high. Few data available on histological evolution these organs especially transplanted into non-diabetic patients who remain euglycemic. Methods We describe ten kidney biopsies performed recipients diabetic donors. Results Mean donor age was 69 ± 7 years, 60% were males. Two treated with insulin, eight oral antidiabetic drugs. recipient 59.9 70% The pre-existing...
Abstract Background Normothermic and hypothermic oxygenated perfusion for donation after circulatory death in kidney transplantation are becoming popular Italy, with the purpose of reducing risk primary non function delayed graft due to prolonged warm ischemia time. Potential complications related these procedures currently under investigation continuously emerging increasing experience. Post-operative infections - particular arteritis a rare complication but determine high mortality loss....
Both amylase and resistive index (RI) are routinely measured after kidney transplant proposed as markers of delayed graft function (DGF).This retrospective cross-sectional study analyzed RI in 269 renal recipients before transplantation, at discharge. An increase above 20% total with/without RI>0.7 were evaluated prognostic DGF, hospitalization length risk rejection.Serum >20% was found 103/269 (38.3%) patients who showed DGF (45.6% vs. 25.3%, p=0.001) had lower estimated glomerular...