A5012545390- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Epilepsy research and treatment
- Neurological disorders and treatments
- Ion channel regulation and function
- Genetic Neurodegenerative Diseases
- Pharmacological Effects and Toxicity Studies
- Cerebrospinal fluid and hydrocephalus
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Glioma Diagnosis and Treatment
- Glycogen Storage Diseases and Myoclonus
- Amino Acid Enzymes and Metabolism
- Neonatal and fetal brain pathology
- Attention Deficit Hyperactivity Disorder
- GABA and Rice Research
- Neurology and Historical Studies
- Biochemical effects in animals
- Parkinson's Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Cannabis and Cannabinoid Research
- Fetal and Pediatric Neurological Disorders
- Neurosurgical Procedures and Complications
- Photoreceptor and optogenetics research
- Ubiquitin and proteasome pathways
Athabasca University
2023
University of California, Los Angeles
2014-2018
UCLA Medical Center
2007-2015
Harbor–UCLA Medical Center
2007-2015
Children's Hospital of Los Angeles
1983-2008
University of Southern California
1984-2006
University of Mississippi Medical Center
1993-2001
Jackson Memorial Hospital
1994-1999
University of Miami
1989
Indiana University – Purdue University Indianapolis
1986
Abstract Persons symptomatic and at risk for Huntington's disease (HD) from a large extended family in the state of Zulia, Venezuela, have been followed prospectively 7 years. Between 1981 1988, 593 people were examined, whom 128 had HD 171 persons examination abnormalities that insufficient to meet criteria diagnosis. The remaining 294 normal examinations. Abnormalities saccadic eye movement slowness rapid alternating movements most common found at‐risk individuals. Thirty who did not...
We studied 65 Huntington's disease patients and 225 at-risk individuals over the past 4 years. The rate of decline these untreated from Venezuela was similar to that seen in US who had received neuroleptic drugs. Chorea, oculomotor dysfunction, dysdiadochokinesis were early symptoms; parkinsonian features dystonia came later. Juvenile declined nearly twice as fast adult-onset patients. No distinctive neurologic phenotypes children two affected parents.
Abstract Starch, glycogen, maltooligosaccharides, and other α-1,4- α-1,6-linked glucose carbohydrates, exclusive of resistant starch, are collectively termed "dietary starch". This nutritionally important fraction is increasingly measured for use in diet formulation animals as it can have positive or negative effects on animal performance health by affecting energy supply, glycemic index, formation fermentation products gut microbes. AOAC Method 920.40 that was used measuring dietary starch...
Status epilepticus refractory to initial anticonvulsant therapy is a serious condition with high morbidity and mortality. We present 50 cases status (RSE) treated very-high-dose phenobarbital (VHDPB) without reference predetermined maximum level or dose. Maximum serum levels ranged from 70 344 μg/ml (median, 114 μg/ml). VHDPB controlled seizures in all where no limits were imposed upon dose (47/50). found beyond which further doses are likely be ineffective. Forty patients intubated prior...
Summary Age of onset for Huntington's disease (HD) varies inversely with the length disease‐causing CAG repeat expansion in HD gene. A simple exponential regression model yielded adjusted R‐squared values 0.728 a large set Venezuelan kindreds and 0.642 North American, European, Australian sample (the MAPS cohort). We present evidence that two‐segment curve provides significantly better fit than regression. plot natural log‐transformed age against reveals this segmental relationship. This on...
We describe a 34-year-old man with 17-year history of multifocal fibrosclerosis resulting in unique neurologic complications. Episcleritis, orbital pseudotumor, and sclerosing cholangitis accompanied florid intracranial inflammatory pachymeningitis. The latter was associated blindness, multiple cranial neuropathies, pseudotumor cerebri, seizures. Extensive investigation failed to reveal an etiology. Corticosteroids were ineffective preventing progression the disorder, value antineoplastic...
We report our experience with 300 consecutive parenteral doses of lorazepam (LOR) for status epilepticus (SE) or serial seizures in 77 children and young adults. The median dose SE less than 12 years old was 0.10 mg/kg. LOR stopped the 79% diminished intensity an additional 4%. Prior acute chronic anticonvulsant use (excepting benzodiazepines) did not alter effectiveness increase side effects. Duration freedom from following therapy independent dosage. In patients requiring sequential doses,...
Abstract— The effect of amino‐oxyacetic acid on the uptake [ 3 H]GABA by rat brain slices was studied. When added simultaneously with H]GABA, had no significant uptake. However, preincubation prior to addition produced inhibition uptake, which increased longer duration preincubation. inhibitory maximal at 2 mM concentration and concentrations sufficient inhibit significantly GABA:glutamate transaminase (10 ‐ 6 M) D‐Cycloserine β‐hydrazino‐propionic also inhibited but amounts required were...
Journal Article Primary Intracranial Neoplasms: Prognosis and Classification of 513 Verified Cases Get access K. M. Earle, M.D., M.D. Galveston, Texas Search for other works by this author on: Oxford Academic PubMed Google Scholar E. H. Rentschler, S. R. Snodgrass, Neuropathology & Experimental Neurology, Volume 16, Issue 3, July 1957, Pages 321–331, https://doi.org/10.1097/00005072-195707000-00003 Published: 01 1957
Five children with subacute or acute onset of cerebellar ataxia and opsoclonus are described. Two had cerebrospinal fluid pleocytosis at the were initially thought to have parainfectious childhood. All found tumors neural crest origin (two neuroblastomas, three ganglioneuroblastomas). Tumors small only by computed tomographic techniques. Urinary catecholamine metabolites elevated in two patients. Four five failed improve neurologically resection tumor. four a steroid-sensitive chronic ataxic...
Abstract —The tryptamine content of rat and mouse brain spinal cord was determined with a radiochemical derivative assay, using [ 3 H]dansyl chloride. The amine extracted into toluene‐isoamyl alcohol, back‐extracted dilute acid, then adsorbed onto non‐ionic polystyrene resin, dansylated in tetrahydrofuran after elution from the resin. Optimum recoveries were obtained TCA extracts, although significant losses occurred due to surface adsorption protein binding. increased MAO inhibition not...