A5102961585- Schizophrenia research and treatment
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Mental Health Treatment and Access
- Neurological disorders and treatments
- Mental Health and Psychiatry
- Mitochondrial Function and Pathology
- Restless Legs Syndrome Research
- Psychosomatic Disorders and Their Treatments
- Advanced MRI Techniques and Applications
- Signaling Pathways in Disease
- Neurological and metabolic disorders
- Obsessive-Compulsive Spectrum Disorders
- Neuroscience and Neuropharmacology Research
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Migraine and Headache Studies
- DNA Repair Mechanisms
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Nitric Oxide and Endothelin Effects
- Genetics and Neurodevelopmental Disorders
- RNA regulation and disease
- Functional Brain Connectivity Studies
- Celiac Disease Research and Management
Johns Hopkins University
2014-2025
Johns Hopkins Medicine
2013-2025
Johns Hopkins Bayview Medical Center
2019-2021
Universidade Federal de São Paulo
2021
Pew Charitable Trusts
2021
University of Pittsburgh
2019
Johns Hopkins Hospital
2018
University of Maryland, Baltimore
2012
University of Maryland Medical Center
2012
Parkinson’s Disease and Movement Disorder Center of Silicon Valley
2012
Abstract Anxiety disorders are common in Parkinson's disease (PD), but not well characterized. This study determined the prevalence and clinical correlates of all DSM‐IV‐TR anxiety disorder diagnoses a sample 127 subjects with idiopathic PD who underwent comprehensive assessments administered by psychiatrist neurologist. A panel six psychiatrists expertise geriatric psychiatry and/or movement established consensus psychiatric diagnoses. Current lifetime at least one diagnosis was 43% (n =...
Human genes containing triplet repeats may markedly expand in length and cause neuropsychiatric disease, explaining the phenomenon of anticipation (increasing severity or earlier age onset successive generations a pedigree). To identify novel with repeats, we screened human brain cDNA library oligonucleotide probes CTG CCG repeats. Fourteen 40 clones encoded genes, 8 these inserts have been sequenced on both strands. All contain 5 9 more consecutive perfect are expressed brain. Chromosomal...
The Methods of Optimal Depression Detection in Parkinson's Disease (MOOD-PD) study compared the psychometric properties 9 depression scales to provide guidance on scale selection Parkinson disease (PD).Patients with PD (n = 229) from community-based neurology practices completed 6 self-report (Beck Inventory [BDI]-II, Center for Epidemiologic Studies Rating Scale-Revised [CESD-R], 30-item Geriatric Scale [GDS-30], Depressive Symptoms-Patient [IDS-SR], Patient Health Questionnaire-9 [PHQ-9],...
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy (DRPLA). The normal function atrophin-1 unknown. We have identified five interacting proteins (AIPs) bind to in the vicinity tract using yeast two-hybrid system. Four interactions were confirmed usingin vitrobinding assays. All interactors contained multiple WW domains. Two are novel. AIPs can be divided into two distinct classes. AIP1 AIP3/WWP3 MAGUK-like multidomain...
Summary Age of onset for Huntington's disease (HD) varies inversely with the length disease‐causing CAG repeat expansion in HD gene. A simple exponential regression model yielded adjusted R‐squared values 0.728 a large set Venezuelan kindreds and 0.642 North American, European, Australian sample (the MAPS cohort). We present evidence that two‐segment curve provides significantly better fit than regression. plot natural log‐transformed age against reveals this segmental relationship. This on...
Metabolic dysfunction and microvascular abnormality may contribute to the pathogenesis of schizophrenia. Most previous studies cerebral perfusion in schizophrenia measured total blood volume (CBV) flow (CBF) brain, which reflect ensemble signal from arteriolar, capillary, venular compartments microvasculature. As arterioles are most actively regulated vessels among these compartments, they be sensitive component microvasculature metabolic disturbances. In this study, we adopted inflow-based...
ABSTRACT Aim Connection Learning Healthcare System, one of the eight hubs National Institute Mental Health funded Early Psychosis Intervention Network, supports uniform data collection, analysis, feedback and infrastructure development to promote a culture continuous quality improvement across 25 Coordinated Specialty Care programs serving young people experiencing first episode psychosis their families in Maryland Pennsylvania. This report describes hub its constituent programs, approach...
Abstract Background and Hypothesis Clozapine remains the gold standard for treatment-resistant schizophrenia (TRS), yet time course of clinical response in naturalistic settings is not well characterized. We hypothesized that patients initiated on clozapine an outpatient clinic would demonstrate measurable symptom reduction over time, including delayed a subset patients. Study Design conducted retrospective study TRS (N=26) newly at clinic. Symptoms were assessed using Positive Negative...
Nonpsychiatric house staff referring inpatients for psychiatric consultation were asked to make a diagnosis before their patients evaluated by the consultants. The psychiatrists confirmed this in only 22% of age 50 years and older, but 68% under 50. Referring physicians identified 27 cases major depression; consultants agreed with 6 (22%) these patients. In remaining 21 patients, 10 delirium, 7 adjustment disorder, 4 various other conditions. These results suggest that nonpsychiatric...
This study examined whether outpatients with a psychotic disorder who are at risk of hospitalization can be identified by using data from electronic medical records (EMRs).Data EMRs enrolled in two clinics for treatment disorders were abstracted. Monthly collected 75 patients over years. The the association medication nonadherence, substance use, participation psychiatric rehabilitation, and long-acting injectable antipsychotic use any given month subsequent generalized estimating...