A5002386892- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Insect and Pesticide Research
- Leptospirosis research and findings
- Parasites and Host Interactions
- Vector-borne infectious diseases
- Dermatological diseases and infestations
- Biosensors and Analytical Detection
- SARS-CoV-2 detection and testing
- Synthesis and Biological Evaluation
- Viral Infections and Vectors
- Insect symbiosis and bacterial influences
- Viral Infectious Diseases and Gene Expression in Insects
- Parasitic Diseases Research and Treatment
- Eosinophilic Disorders and Syndromes
- Urticaria and Related Conditions
- Advanced biosensing and bioanalysis techniques
- Insect Pest Control Strategies
- Vector-Borne Animal Diseases
- T-cell and Retrovirus Studies
- Bat Biology and Ecology Studies
- Bird parasitology and diseases
- Herpesvirus Infections and Treatments
- Evolution and Paleontology Studies
- Animal Ecology and Behavior Studies
The University of Texas Medical Branch at Galveston
2015-2024
Centro Internacional de Entrenamiento e Investigaciones Medicas
2001-2017
National University of Misiones
2015
Baylor University
2015
South Texas Veterans Health Care System
2008-2012
The University of Texas Health Science Center at San Antonio
2006-2012
The University of Texas Health Science Center at Houston
2006-2012
University of Wisconsin–Oshkosh
2000-2002
Instituto Nacional de Salud
2002
Universidad del Valle
1995-2002
We studied the reservoir competency of canines with distinct clinical presentations Leishmania chagasi infection. The parasitologic status asymptomatic and symptomatic dogs was determined by standard culture methods Infectivity assessed multiple xenodiagnoses Lutzomyia longipalpis, over a period 2-11 months. Asymptomatic were non-infective (0 5) while 2 7 oligosymptomatic infected L transmitting parasites at low rates (range 0.9-5.2% engorged flies). Polysymptomatic transmitted L. more...
ABSTRACT In regions where leishmaniasis is endemic, clinical disease usually reported more frequently among males than females. This difference could be due to disparate risks of exposure and females, but gender-related differences in the host response infection may also play a role. Experimental studies influence gender on Leishmania have not included parasites subgenus Viannia , which most common cause cutaneous Americas. Mice are readily susceptible by ( ) spp., hamsters with L. V....
Visceral Leishmaniasis (VL), caused by the intracellular protozoan Leishmania donovani, is characterized relentlessly increasing visceral parasite replication, cachexia, massive splenomegaly, pancytopenia and ultimately death. Progressive disease considered to be due impaired effector T cell function and/or failure of macrophages activated kill parasite. In previous studies, we used Syrian hamster (Mesocricetus auratus) as a model because it mimics progressive nature active human VL. We...
Acute malnutrition, or wasting, is implicated in over half of all deaths children under five and increases risk infectious disease. Studies humans preclinical models have demonstrated that malnutrition linked to an immature intestinal microbiota characterized by increased prevalence Enterobacteriaceae. Observational studies with moderate acute (MAM) also observed heightened systemic inflammation circulating bacterial lipopolysaccharides (LPS; endotoxin). However, the mechanisms underpin...
"Didelphis marsupialis, an Important Reservoir of Trypanosoma (Schizotrypanum) cruzi and Leishmania (Leishmania) chagasi in Colombia" published on May 1994 by The American Society Tropical Medicine Hygiene.
Journal Article Lutzomyia evansi, an alternate vector of Leishmania chagasi in a Colombian focus visceral leishmaniasis Get access B.L. Travi, Travi 1Centro International de Investigacions Médicas, Apartado Aéreo 5390, Cali, Colombia Search for other works by this author on: Oxford Academic PubMed Google Scholar I.D. Vélez, Vélez 2Sección Parasitología, Facultad Medicina, Universidad Antioquia, 1226, Medellín, L. Brutus, Brutus I. Segura, Segura C. Jaramillo, Jaramillo J. Montoya...
Phlebotomine sand flies (Diptera: Psychodidae) were captured in an area of Argentina endemic for American cutaneous leishmaniasis (ACL). A total 44,944 collected during a 130-wk interepidemic period from 1990 through 1993. These included Lutzomyia neivai (Pinto) (97.8%), migonei (França) (1.2%), cortelezzii (Brèthes) (0.8%), shannoni (Dyar) (0.1%), and punctigeniculata (Floch Abonnenc) (0.1%). was more abundant secondary forests peridomestic environments associated with human cases than...
Background New drugs are needed to treat visceral leishmaniasis (VL) because the current therapies toxic, expensive, and parasite resistance may weaken drug efficacy. We established a novel ex vivo splenic explant culture system from hamsters infected with luciferase-transfected Leishmania donovani screen chemical compounds for anti-leishmanial activity. Methodology/Principal Findings This model has advantages over in vitro systems that it: 1) includes whole cellular population involved...
Host arginase 1 (arg1) expression is a significant contributor to the pathogenesis of progressive visceral leishmaniasis (VL), neglected tropical disease caused by intracellular protozoan Leishmania donovani. Previously we found that parasite-induced arg1 in macrophages was dependent on STAT6 activation. Arg1 amplified by, but did not require, IL-4, and required de novo synthesis unknown protein(s). To further explore mechanisms involved regulation VL, screened panel kinase inhibitors growth...
Cutaneous and mucosal leishmaniasis is widely distributed in Central South America. Leishmania of the Viannia subgenus are most frequent species infecting humans. L. (V.) braziliensis, panamensis also responsible for metastatic leishmaniasis. Conventional or real time PCR a more sensitive diagnostic test than microscopy, but cost requirement infrastructure trained personnel makes it impractical endemic regions. Primary health systems need specific point care (POC) tool. We developed novel...
Journal Article Bionomics of Lutzomyia evansi (Diptera: Psychodidae) Vector Visceral Leishmaniasis in Northern Colombia Get access Bruno L. Travi, Travi Centro Internacional de Entrenamiento e Investigaciones M6dicas-CIDE1M, A.A. 5390, Cali, Search for other works by this author on: Oxford Academic PubMed Google Scholar James Montoya, Montoya Jorge Gallego, Gallego 1 1Servicio Leishrnaniosis, Facultad Salud Pública, Universidad Antioquia, Calle 62 52-19, Medellín, Colombia. Consuelo...
The infectivity of Leishmania braziliensis ssp. in relation to their growth kinetics Senekjie's medium was determined using the human macrophage cell line U937 and inbred hamsters. In both systems, shown be distinctive for each subspecies. While L. b. panamensis promastigotes from 6-day-old cultures (early stationary phase) were more infective than parasites any other culture day, guyanensis reached maximum on days 8–10 day 10 (late phase growth), respectively. Although occurred during...
Abstract Background The Syrian hamster, Mesocricetus auratus , has distinct immunological features and is uniquely susceptible to intracellular pathogens. Studies in hamsters are limited by the relative unavailability of tools conduct studies. To address this limitation we developed duplex real-time reverse transcriptase (RT) PCR assays for quantification mRNAs hamster cytokines, chemokines, related immune response molecules. Results Real-time RT-PCR primers probes were synthesized analysis...
The clinicopathological features of the hamster model visceral leishmaniasis (VL) closely mimic active human disease. Studies in humans and hamsters indicate that inability to control parasite replication VL could be related ineffective classical macrophage activation. Therefore, we hypothesized pathogenesis might driven by a program alternative Indeed, infected spleen showed low NOS2 but high arg1 enzyme activity protein mRNA expression (p<0.001) increased polyamine synthesis (p<0.05)....
Visceral leishmaniasis (VL), caused by infection with the intracellular protozoan Leishmania donovani, is a chronic progressive disease relentlessly increasing parasite burden in spleen, liver and bone marrow. The characterized fever, splenomegaly, cachexia, pancytopenia, progresses to death if not treated. Control of mediated Th1 (IFNγ-producing) CD4+ T cells, which activate macrophages produce nitric oxide kill parasites. However, despite expansion cells increased IFNγ expression humans...
Journal Article Impact of Habitat Degradation on Phlebotominae (Diptera: Psychodidae) Tropical Dry Forests in Northern Colombia Get access Bruno L. Travi, Travi 1E-mail: travib@cideim.org.co. Search for other works by this author on: Oxford Academic PubMed Google Scholar Gregory H. Adler, Adler 2Department Biology and Microbiology, University Wisconsin, Oshkosh, WI 54901. Margarita Lozano, Lozano 3Universidad del Valle, Cali, Colombia. Horacio Cadena, Cadena Centro Internacional de...
BackgroundAmerican cutaneous leishmaniasis is considered to be a zoonotic disease transmitted by sand flies that feed on infected sylvatic mammals. However, the “domestication” of transmission and increase in treatment failure with antimonial drugs have raised suspicion anthroponotic American MethodsThe objective present study was explore potential humans as source infection for flies. Biological (xenodiagnosis culture) molecular (polymerase chain reaction/Southern blot) detection methods...