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Gabriel Bandeira do Carmo

ORCID: 0000-0003-4168-152X
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About
Contact & Profiles
A5041534404
Research Areas
  • Genomic variations and chromosomal abnormalities
  • BRCA gene mutations in cancer
  • Sarcoma Diagnosis and Treatment
  • Cancer-related gene regulation
  • Cancer-related Molecular Pathways
  • Hedgehog Signaling Pathway Studies
  • RNA modifications and cancer

Universidade de São Paulo
 2023

 Analysis of the Mutational Landscape of Osteosarcomas Identifies Genes Related to Metastasis and Prognosis and Disrupted Biological Pathways of Immune Response and Bone Development
OPENALEX - Publications 
Sara Ferreira Pires Juliana Sobral de Barros Silvia Souza da Costa Gabriel Bandeira do Carmo Marília O. Scliar and 6 more André van Helvoort Lengert Érica Boldrini Sandra Regini Morini da Silva Daniel Onofre Vidal Mariana Maschietto Ana Cristina Victorino Krepischi

Osteosarcoma (OS) is the most prevalent type of bone tumor, but slow progress has been achieved in disentangling full set genomic events involved its initiation and progression. We assessed by NGS mutational spectrum 28 primary OSs from Brazilian patients, identified 445 potentially deleterious SNVs/indels 1176 copy number alterations (CNAs). TP53 was recurrently mutated gene, with an overall rate ~60%, considering CNAs. The frequent CNAs (~60%) were gains at 1q21.2q21.3, 6p21.1,...

10.3390/ijms241310463 article EN International Journal of Molecular Sciences 2023-06-21
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