Unprecedented self-sorting of three-dimensional purely organic cages driven by dynamic covalent bonds is described. Four different were first synthesized condensation two triamines and dialdehydes separately. When a mixture all the components was allowed to react, only formed, which suggests high-fidelity self-recognition. The issue preference one triamine for particular dialdehyde further probed transforming non-preferred combination either preferred combinations reacting it with...

Engineering at the molecular level is one of most exciting new developments for generation functional materials. However, concept designing polynuclear extended structures from bottom up still not mature. Although progress has been made with secondary building units (SBUs) in metal organic frameworks (MOFs), control seems to be just an illusion when it comes bridging ligands such as azide ion. When we say that azido ligand versatile its capabilities, what mean would difficult predict or...

Abstract The two‐component self‐assembly of a 90° Pd II acceptor and triimidazole donor led to the formation water‐soluble semi‐cylindrical cage with hydrophobic cavity, which was separately crystallized hydrophilic‐ guests. parent found catalyze Knoevenagel condensation reaction series aromatic mono‐aldehydes active methylene compounds, such as Meldrum′s acid or 1,3‐dimethylbarbituric acid. confined nanospace within this also used in catalytic Diels–Alder reactions 9‐hydroxymethylanthracene...

The reaction of a tridentate Schiff base ligand HL (2-[(3-dimethylaminopropylimino)-methyl]-phenol) with Ni(II) acetate or perchlorate salts in the presence azide as coligand has led to two new complexes formulas [Ni(3)L(2)(OAc)(2)(μ(1,1)-N(3))(2)(H(2)O)(2)]·2H(2)O (1) and [Ni(2)L(2)(μ(1,1)-N(3))(μ(1,3)-N(3))](n)(2). Single crystal X-ray structures show that complex 1 is linear trinuclear compound containing μ(2)-phenoxido, an end-on (EO) azido syn-syn acetato bridge between terminal central...

The molecular mechanism of antimony-resistant Leishmania donovani (Sb R LD)–driven up-regulation IL-10 and multidrug-resistant protein 1 (MDR1) in infected macrophages (Mϕs) has been investigated. This study showed that both promastigote amastigote forms Sb LD, but not the antimony-sensitive form express a unique glycan with N -acetylgalactosamine as terminal sugar. Removal it either by enzyme treatment or knocking down relevant enzyme, galactosyltransferase LD (KD LD), compromises ability...

Four new neutral copper azido polymers, [Cu4(N3)8(L1)2]n (1), [Cu4(N3)8(L2)2]n (2), [Cu4(N3)8(L3)2]n (3), and [Cu9(N3)18(L4)4]n (4) [L1−4 are formed in situ by reacting pyridine-2-carboxaldehyde with 2-[2-(methylamino)ethyl]pyridine (mapy, L1), N,N-dimethylethylenediamine (N,N-dmen, L2), N,N-diethylethylenediamine (N,N-deen, L3), N,N,2,2-tetramethylpropanediamine (N,N,2,2-tmpn, L4)], have been synthesized using 0.5 mol equiv of the chelating tridentate ligands Cu(NO3)2·3H2O an excess NaN3....

Despite the presence of significant levels systemic Interferon gamma (IFNγ), host protective cytokine, Kala-azar patients display high parasite load with downregulated IFNγ signaling in Leishmania donovani (LD) infected macrophages (LD-MØs); cause such aberrant phenomenon is unknown. Here we reveal for first time mechanistic basis impaired parasitized murine macrophages. Our study clearly shows that LD-MØs receptor (IFNγR) expression and their ligand-affinity remained unaltered. The...

Three new copper-azido complexes [Cu(4)(N(3))(8)(L(1))(2)](n) (1), [Cu(4)(N(3))(6)(L(2))(2)(H(2)O)(2)] (2), and [Cu(4)(N(3))(6)(L(3))(2)](n) (3) [L(1) is the imine resulting from condensation of pyridine-2-carboxaldehyde with N-methylethylenediamine, HL(2) HL(3) are products 2-hydroxy-3-methoxybenzaldehyde N,N-diethylethylenediamine N-ethylethylenediamine respectively] have been synthesized by using 0.5 molar equivalents Schiff base ligands Cu(NO(3))(2)·3H(2)O an excess NaN(3). Single...

In this article we present the syntheses, characterizations, magnetic and luminescence properties of five 3d-metal complexes, [Co(tib)(1,2-phda)]n·(H2O)n (1), [Co3(tib)2(1,3-phda)3(H2O)]n·(H2O)2n (2), [Co5(tib)3(1,4-phda)5(H2O)3]n·(H2O)7n (3), [Zn3(tib)2(1,3-phda)3]n·(H2O)4n (4), [Mn(tib)2(H2O)2]n·(1,4-phdaH)2n·(H2O)4n (5), obtained from use isomeric phenylenediacetates (phda) neutral 1,3,5-tris(1-imidazolyl)benzene (tib) ligand. Single crystal X-ray structures showed that 1 constitutes...

Antimonial (sodium stibogluconate, SSG) resistance and differentiation have been shown to be closely linked in Leishmania donovani, with SSG-resistant strains showing an increased capacity generate infectious (metacyclic) forms. This is the first untargeted LC-MS metabolomics study which integrated both phenomena one experimental design provided insights into metabolic differences between three clinical L. donovani a similar genetic background but different SSG-susceptibilities. We performed...

Two heterometallic coordination polymers (CPs) have been prepared using [NiIIL]2CoII (where H2L = N,N′-bis(salicylidene)-1,3-propanediamine) as nodes and dicyanamido spacers by varying the solvent for synthesis. Structural characterizations revealed that methanol assisted formation of a two-dimensional (4,4) connected rhombic grid network [(NiL)2Co(NCNCN)2]∞ (1a) whereas relatively less polar acetonitrile afforded different superstructure {[(NiL)2Co(NCNCN)2]·CH3CN}∞ (1b) with square network....

Abstract In the context of failure treatment for non alcoholic fatty liver disease (NAFLD)-mediated systemic damages, recognition novel and successful characteristic drug to combat these anomalous situations is earnestly required. The present study aimed evaluate protective value ethanol extract Coccinia grandis leaves (EECGL), naturally occurring medicinal plant, on NAFLD-mediated damage induced by high lipid diet along with monosodium glutamate (HM)-fed rats. Our uncovered that EECGL...

Since prehistoric times Coccinia grandis has been used as traditional medicine for various diseases including diabetes, dyslipidemia, metabolic and digestive disorders. Although the rationality of efficacy natural antioxidants with different bioactive compounds in against monosodium glutamate (MSG) induced hepato-cardiac damage remains to be disclosed. Six solvent extracts leaves were chosen evaluate vitro antioxidant free radical (FR)-scavenging activity. Due high content FR-scavenging...

People in the fast-food era rely on pre-packaged foods and engage limited physical activity, which leads to a shift eating patterns. Monosodium glutamate (MSG), dietary ingredient used this sort of cuisine, has been found be hazardous both experimental animals humans. The objective study was explore at unnecessary changes caused by consuming MSG secret exceeding recommended dosage. Hence, we decided evaluate impact using three different doses (200, 400, 600 mg/kg body weight orally) for 28...

Two new neutral copper-azido polymers [Cu3(N3)6(tmen)2]n (1) and [Cu6(N3)12(deen)2]n (2) [tmen = N,N,N′,N′-tetramethylethylenediamine deen N,N′-diethylethylenediamine] have been synthesized by using lower molar equivalents of the chelating diamine ligands with Cu(NO3)2·3H2O an excess NaN3. The single crystal X-ray structure shows that in basic unit 1D complex 1, three CuII ions are linked double end-on azido bridges Cu−NEO−Cu angles on both sides magnetic exchange critical angle 108°....

Background In an endeavor to find orally active and affordable antileishmanial drug, we tested the efficacy of a cationic amphiphilic imipramine, commonly used for treatment depression in humans. The only available drug is miltefosine with long half life teratogenic potential limits patient compliance. Thus there genuine need drug. Previously it was shown that tricyclic antidepressant alters protonmotive force promastigotes, but its vivo not reported. Methodology/Principal Findings Here show...

Globally, the trend of using food additives and eating ready-made fast has led to a deleterious impact on immune organs. Monosodium glutamate (MSG), as additive in high-lipid diet (HLD), acts silent killer cells. Hence, present study aimed evaluate role MSG HLD spleen injury rats. Results showed that 2.52-fold 1.91-fold increase index + group indicates splenomegaly, whereas 1.36-fold 1.29-fold pro-inflammatory cytokines HLD-fed rats, respectively, promote inflammatory response. Additionally,...

Abstract Bisphenol-A (BPA) is widely used in food packaging and household products, leading to daily human exposure potential health risks including metabolic diseases like type 2 diabetes mellitus (T2DM). Understanding BPA's mechanisms developing intervention strategies urgent. Centella asiatica , a traditional herbal medicine containing pentacyclic triterpenoids, shows promise due its antioxidant anti-inflammatory properties, utilized for centuries Ayurvedic therapy. We investigated the...