A5083008310- vaccines and immunoinformatics approaches
- Research on Leishmaniasis Studies
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- Trypanosoma species research and implications
- Transgenic Plants and Applications
- Parasites and Host Interactions
- Bacteriophages and microbial interactions
- Synthesis and Biological Evaluation
- MicroRNA in disease regulation
- Multiple Myeloma Research and Treatments
- Synthesis and biological activity
- Endoplasmic Reticulum Stress and Disease
- Malaria Research and Control
- Acute Myeloid Leukemia Research
- Viral gastroenteritis research and epidemiology
- Autophagy in Disease and Therapy
- CAR-T cell therapy research
- Virus-based gene therapy research
- Mosquito-borne diseases and control
- Polyomavirus and related diseases
- Toxin Mechanisms and Immunotoxins
- Acute Lymphoblastic Leukemia research
University of Delhi
2023-2025
All India Institute of Medical Sciences
2020-2024
All India Institute of Medical Sciences Bhopal
2021-2024
All India Institute of Medical Sciences Raipur
2023-2024
Government Medical College
2024
Indian Agricultural Research Institute
2024
Central University of Rajasthan
2013-2023
Central University of Punjab
2022-2023
University of Allahabad
2023
Indian Council of Agricultural Research
2023
Dengue is considered as a major health issue which causes number of deaths worldwide each year; tropical countries are majorly affected by dengue outbreaks. It life threatening because, since many decades not single effective approach for treatment and prevention has been developed. Therefore, to find new preventive measure, we used immunoinformatics approaches develop multi-epitope based subunit vaccine can generate various immune responses inside the host. Different B-cell, T
Visceral leishmaniasis (VL) is a fatal form of which affects 70 countries, worldwide. Increasing drug resistance, HIV co-infection, and poor health system require operative vaccination strategy to control the VL transmission dynamics. Therefore, holistic approach needed generate T B memory cells mediate long-term immunity against infection. Consequently, immunoinformatics was applied design Leishmania secretory protein based multi-epitope subunit vaccine construct consisting cell epitopes....
Miltefosine is the only oral drug available for treatment of Indian visceral leishmaniasis (VL), which was shown to have an efficacy 94% in a phase III trial subcontinent. Its unrestricted use has raised concern about its continued effectiveness. This study evaluates and safety miltefosine VL after decade India.An open-label, noncomparative performed 567 patients received (50 mg weighing <25 kg, 100 divided doses those ≥25 2.5 per kg aged <12 years, daily 28 days) directly observed manner....
Abstract Malaria fever has been pervasive for quite a while in tropical developing regions causing high morbidity and mortality. The causal organism is protozoan parasite of genus Plasmodium which spreads to the human host by bite hitherto infected female Anopheles mosquito. In course biting, salivary protein helps blood feeding behavior having ability elicit immune response. This study represents series immunoinformatics approaches design multi-epitope subunit vaccine using mosquito...
Leishmania donovani causes visceral leishmaniasis (VL), the second most deadly vector-borne parasitic disease. A recent epidemic in Indian subcontinent (ISC) caused up to 80% of global VL and over 30,000 deaths per year. Resistance against antimonial drugs has probably been a contributing factor persistence this epidemic. Here we use whole genome sequences from 204 clinical isolates track evolution epidemiology L. ISC. We identify independent radiations that have emerged since bottleneck...
This study describes the antileishmanial efficacy of novel drug formulation amphotericin B (AmB) attached to functionalized carbon nanotubes (f-CNTs) and compares it with AmB. f-CNTs were prepared in a two-step chemical carboxylation amidation process. The AmB was then make f-CNT–AmB its construction confirmed by Fourier transform infrared (FTIR) spectroscopy transmission electron microscopy (TEM). cytotoxicity constructed compound, f-CNT–AmB, assessed vitro using J774A.1 macrophage cell...
Background With widespread resistance to antimonials in Visceral Leishmaniasis (VL) the Indian subcontinent, Miltefosine (MIL) has been introduced as first line therapy. Surveillance of MIL susceptibility natural populations Leishmania donovani is vital preserve it and support VL elimination program. Methodology Principal Findings We measured vitro towards paromomycin (PMM) L. isolated from PKDL, pre- post-treatment cases, using an amastigote-macrophage model. isolates cured cases (n = 13,...
The Zika virus is a rapidly spreading Aedes mosquito-borne sickness, which creates an unanticipated linkage birth deformity and neurological turmoil. This study represents the use of combinatorial immunoinformatics approach to develop multiepitope subunit vaccine using structural nonstructural proteins virus. designed consists cytotoxic T-lymphocyte helper epitopes accompanied by suitable adjuvant linkers. presence humoral immune response specific B-cell was also confirmed epitope mapping...
COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily appeared in Wuhan, China, December 2019. At present, no proper therapy and vaccinations are available for the disease, it is increasing day with a high mortality rate. Pharmacophore based virtual screening of selected natural product databases followed Glide molecular docking dynamics studies against SARS-CoV-2 main protease was investigated to identify potential ligands that may act as inhibitors. The...
Amphotericin B (AmB), is a highly effective antileishmanial agent used as first-line treatment in different formulations visceral leishmaniasis endemic areas of Bihar, India. However, parenteral infusion, prolonged hospitalization, and toxicity are major hurdles. Our previous work demonstrated the efficacy stability functionalized carbon nanotubes delivery mechanism for AmB. In this study, using hamster model, we have shown that novel formulation AmB can be administered orally, resulting 99%...
Visceral leishmaniasis (VL) is a tropical neglected disease caused by Leishmania donovani, results in significant mortality the Indian subcontinent. The plasticity of T cell proliferation and differentiation depends on microRNA mediated gene regulation which leads Th1/Th2 or Th17/Treg type immune response during human VL. This study depicts identification target signaling molecule transcription factors, play role T-cell followed miRNA controlling their expression using three web servers'...
Nipah virus (NiV) is an emerging zoonotic pathogen, reported for the recent severe outbreaks of encephalitis and respiratory illness in humans animals, respectively. Many antiviral drugs have been discovered to inhibit this but none them were that much efficient. To overcome complications associated with pathogenic virus, we designed a multi-epitope subunit vaccine using computational immunology strategies. Identification structural nonstructural proteins assisted designing. The selected are...
Visceral leishmaniasis affects people from 70 countries worldwide, mostly Indian, African and south American continent. The increasing resistance to antimonial, miltefosine frequent toxicity of amphotericin B drives an urgent need develop antileishmanial drug with excellent efficacy safety profile. In this study we have docked series febrifugine analogues (n = 8813) against trypanothione reductase in three sequential docking modes. Extra precision resulted into 108 ligands showing better...
Tuberculosis (TB) is one of the prevalent causes death worldwide, with 95% these deaths occurring in developing countries, like India. The causative agent, Mycobacterium tuberculosis (MTb) has tenacious ability to circumvent host's immune system for its own advantage. Macrophages are phagocytic cells that central immunity against MTb. These highly plastic dependent on milieu and can showcase M1/M2 polarization. M1 macrophages bactericidal action, but M2 anti-inflammatory their response. This...