COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily appeared in Wuhan, China, December 2019. At present, no proper therapy and vaccinations are available for the disease, it is increasing day with a high mortality rate. Pharmacophore based virtual screening of selected natural product databases followed Glide molecular docking dynamics studies against SARS-CoV-2 main protease was investigated to identify potential ligands that may act as inhibitors. The...

As compared to standard medicinal compounds, hybrid molecules that contain multiple biologically active functional groups have greater affinity and efficiency. Hence based on this concept, we predicted a combination of thiazolidinediones 1,3,4-oxadiazoles may enhance α-amylase α-glucosidase inhibition activity. A series novel 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)thiazolidine-2,5-dione derivatives (5a-5j) were synthesized characterized using different spectroscopic techniques

Premenstrual syndrome (PMS) is known to be a prevalent health concern affecting significant number of women globally and yoga found beneficial in such psychosocial disorders. To evaluate the effectiveness structured intervention by comparing pre-and post-intervention changes severity PMS symptoms cardiac autonomic functions young, healthy female students over course three menstrual cycles. The present study trial conducted Department Physiology, Kasturba Medical College, Manipal which...

The chemical class of benzopyrones consists a large number compounds possessing the benzene ring fused with oxygen containing pyrone ring. This is further divided into benzo-γ-pyrone i.e. flavonoids and benzo-α-pyrone coumarins. Coumarins, 2H-chromen-2-one its related analogues exhibit multitude biological activities. Attempts made in continuous diversification this parent nucleus have brought significant alterations activity among generated therefore, category has been much exploited...

The last decade witnessed several scientific experiments with the aim to correlate structure of chemical entities their biological activities, toxicities and other molecular properties. Chemical species are mathematically represented based on specified algorithms in descriptors. They play extremely important role field chemistry, pharmacy, environmental toxicology health research. Till today, more than 5000 descriptors being reported calculated mainly using dedicated software's, which run...

Calixarenes have always captured the attention of several researchers. They ability to entrap multiple molecules and form inclusion complexes with drugs due their unique structure. Due this property, they are being widely used in development classes drugs, most notably anticancer drugs. This review attempted summarize potential applications calixarenes its derivatives a focus on delivery drug such as DNA intercalators, taxanes, alkylators, topoisomerase inhibitors. Calixarene-based...

Anisochilus carnosus (L.f.) wall (Lamiaceae), an annual herb which grows at high altitude is used extensively in folk medicine for the treatment of ailments such as gastric ulcer and skin diseases. The aim our study was to evaluate anticancer activity different extracts leaves A.carnosus. An attempt also made estimate luteolin content by HPLC (High Performance Liquid Chromatography).In current study, we explored cytotoxic potential petroleum ether, ethanolic aqueous A.carnosus against breast...

BACE-1 is a transmembrane protein occurring in the endoplasmic reticulum that responsible for generation of beta amyloid (Aβ) by cleavage precursor (APP). Deposition and aggregation Aβ brain results onset Alzheimer’s disease (AD). The process drug discovery this area sluggish most developed molecules fail due to toxicity. Research related phytochemicals has taken pace associated low toxicity comparatively. development inhibitors proven be promising treatment strategy AD. In current study,...

Quinazolinone is a versatile lead molecule for designing potential bioactive agents. The compounds that have quinazolin-4-ones moiety are associated with interesting biological activities such as antifungal, antibacterial, antiviral, antitubercular and anticancer. In view of this we undertaken synthesis various thiadiazol substituted quinazolin-4-(3H)-ones. Novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones (5a-5h) were synthesized by reaction 5-alkyl/aryl 1, 4-thiadiazoles...

Celastrus paniculatus, commonly known as Malkangani and Jyothishmati. Which is a traditional medicinal plant used in Ayurveda for various purposes memory enhancer, analgesic, antiepileptic agent, antiinflammatory sedative. The seed extracts are extensively investigated neuropharmacological actions other reports available confirming that the their extract have nontropic action. It also evaluated anti-inflammatory, anticonvulsantaction. drug included many formulations one of content which...

The classical anticancer agents do not have their efficacy on inhibiting the G2 phase of cell cycle. There are a very few reports available drugs that work at phase. Flavopiridol is one such drug candidate. In current study, we sought to make analogues flavopiridol. Still, conditions used during synthesis were unfavourable for formation flavopiridol and led generation benzofuranones. present work, new series benzylidene benzofuranones designed, synthesized evaluated antioxidant,...

A series of novel flavone-4-oximes were synthesized by the oximation substituted flavones. The compounds characterized various spectrochemical methods including IR, MS and NMR spectroscopy. Out 14 test screened for their antioxidant activity, such as JGS-VI (a N,N dimethyl benzaldehyde derivative) JGS-VII 3,4 dimethoxy exhibited activity comparable to that ascorbic acid quercetin standards following DPPH method. Compounds JGS-II p-fluoro derivative), JGS-IV p-methyl JGS-V...

Alzheimer’s disease (AD) is one among the common type of dementia in elder people above age group 65 years. This was once considered a rare disorder but recently as great threat and risk factor to elderly community 60 AD also highly prevalent neurodegenerative disease. characterized by loss neuron disturbed signal between cells brain. The neurotransmitter deficit discovered include acetylcholine (ACh). major pathophysiological character are accumulation extracellular neuritic plaques...

It is well known that microorganisms are omnipresent. would be fascinating for scientists to encounter organisms not only grow in normal conditions but able thrive extreme conditions. Such suitably termed extremophiles including thermophiles, psychrophiles, alkaliphiles, piezophiles, and marine extremophiles, name a few. The UN General Assembly has proposed 17 goals with 169 targets attain sustainable development by 2030 motto of health all. Microorganisms play vital role the well-being just...

Extensive exploration of soil microorganisms in search novel metabolites have edified researchers on the available natural products for drug discovery. Actinomycetes are filamentous Gram positive bacteria capable producing wide array bioactive metabolites. High GC content DNA, makes organism unique and peculiar from other microorganisms. The present article contains data purification characterization L-asparaginase actinomycetes. Soil samples were collected different locations Udupi fish...