A5056768188- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Computational Drug Discovery Methods
- HER2/EGFR in Cancer Research
- Analytical Chemistry and Chromatography
- Multicomponent Synthesis of Heterocycles
- Antibiotics Pharmacokinetics and Efficacy
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Phytochemistry and Bioactive Compounds
- Enzyme function and inhibition
- Cholinesterase and Neurodegenerative Diseases
- Protein Kinase Regulation and GTPase Signaling
- Crystallization and Solubility Studies
- Garlic and Onion Studies
- Heat shock proteins research
- Protein Tyrosine Phosphatases
- PI3K/AKT/mTOR signaling in cancer
- HIV Research and Treatment
- Nuclear Structure and Function
- Ferroptosis and cancer prognosis
- Nitrogen and Sulfur Effects on Brassica
JSS Academy of Higher Education and Research
2022-2025
Objective: Zingiber officinalis (ginger) rhizomes are widely recognised for their health benefits, but the leaves, primarily used as flavouring agents, have not been explored therapeutic potential. This study investigates antiphlogistic properties of Z. Officinalis leaf constituents through molecular docking and dynamic simulation 24 bioactive molecules identified via Gas Chromatography-Mass Spectroscopy (GC-MS), with a focus on pro-inflammatory gene suppression inflammatory cell apoptosis...
Several chemical studies described the physiological efficacy of 1,4- dihydropyridines (DHPs). DHPs bind to specific sites on α1 subunit L-type calcium channels, where they demonstrate a more pronounced inhibition Ca2+ influx in vascular smooth muscle compared myocardial tissue. This selective is basis for their preferential vasodilatory action peripheral and coronary arteries, characteristic that underlies therapeutic utility managing hypertension angina. Among vascular-selective DHPs,...
Decaprenylphosphoryl-β-D-ribose-oxidase (DprE1), a subunit of the essential decaprenylphosphoribose-2'-epimerase, plays crucial role in synthesis cell wall arabinan components mycobacteria, including pathogen responsible for tuberculosis,
Abstract Background The objective of the present investigation was to obtain directly compressible agglomerates ibuprofen with nicotinamide by a quasi-emulsification solvent diffusion technique. Ibuprofen-nicotinamide were prepared technique using ethanol (good solvent), water (poor and chloroform (bridging liquid). characterized ATR-FTIR, powder X-ray diffraction, differential scanning calorimetry, electron microscopy evaluated for tableting performance in vitro drug release. To...
Mycobacterium tuberculosis (Mtb) has numerous cell wall and non-cell mediated receptors for drug action, of which targets were found to be more promising because their pivotal role in bacterial protection survival. Herein, we reported the design synthesis a series pyrazole-linked triazoles based on structural features candidates that target DprE1 through Structure-based (SBDD) approach (6a-6j 7a-7j). The synthesized compounds evaluated in-vitro antitubercular activity against virulent...
In this study, we focus on exploring the medicinal potential of Olea Europaea L., a commonly used plant with diverse indigenous applications. The main aim is to identify promising phytoconstituents from L. leaves that can act as inhibitors for PTP-1B target, utilizing an in silico approach. were sourced IMMPAT database, and molecular docking was employed assess their binding affinities. results revealed rutin (−10.05 kcal/mol) quercetin (−8.28 displayed highest scores against PTP-1B,...
Abstract In the present research work a sequence of substituted quinoline based thiazolidinedione moieties ( 12a–h) were designed and synthesized as potential antidiabetic agents. Pancreatic α‐amylase (PAA) intestinal α‐glucosidase (IAG) enzymes considered targets for effective treatment diabetes. The all compounds (12a–h) was assessed in vitro against PAA IAG using acarbose standard. results suggested that compound 12h has shown superior inhibitory activity with respective to standard (IC...
Abstract Background : Poor solubility of teriflunomide leading to poor bioavailability in disease conditions was a challenge that could be overcome by currently formulated SLNs. Hence, the development sensitive, accurate method for solid-lipid nanoparticles carrying is significantly required analyze and quantify drug formulation release samples. The main aim this study develop simple, linear, precise, accurate, sensitive RP-HPLC with UV detection has been developed validated determination...