A5092887146- Click Chemistry and Applications
- Sphingolipid Metabolism and Signaling
- Protein Kinase Regulation and GTPase Signaling
- HER2/EGFR in Cancer Research
- Lipid metabolism and biosynthesis
- Computational Drug Discovery Methods
- Peroxisome Proliferator-Activated Receptors
- Biochemical and Molecular Research
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Monoclonal and Polyclonal Antibodies Research
- Advanced Breast Cancer Therapies
- Adipose Tissue and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Enzyme function and inhibition
- Metabolism, Diabetes, and Cancer
JSS Academy of Higher Education and Research
2023-2024
Decaprenylphosphoryl-β-D-ribose-oxidase (DprE1), a subunit of the essential decaprenylphosphoribose-2'-epimerase, plays crucial role in synthesis cell wall arabinan components mycobacteria, including pathogen responsible for tuberculosis,
Mycobacterium tuberculosis (Mtb) has numerous cell wall and non-cell mediated receptors for drug action, of which targets were found to be more promising because their pivotal role in bacterial protection survival. Herein, we reported the design synthesis a series pyrazole-linked triazoles based on structural features candidates that target DprE1 through Structure-based (SBDD) approach (6a-6j 7a-7j). The synthesized compounds evaluated in-vitro antitubercular activity against virulent...
Breast cancer has been a leading cause of mortality among women worldwide in recent years. Targeting the lysophosphatidic acid (LPA)-LPA