A5103112740- Nanoparticle-Based Drug Delivery
- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Anodic Oxide Films and Nanostructures
- Wound Healing and Treatments
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Graphene and Nanomaterials Applications
- Renal Transplantation Outcomes and Treatments
- RNA Interference and Gene Delivery
- Hepatitis C virus research
- Renal cell carcinoma treatment
- Transplantation: Methods and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Blood properties and coagulation
- Gallbladder and Bile Duct Disorders
- Nanofabrication and Lithography Techniques
- Advanced biosensing and bioanalysis techniques
- Diversity and Career in Medicine
- Polyomavirus and related diseases
- Genetic and Kidney Cyst Diseases
University of Siegen
2012-2025
Tehran University of Medical Sciences
2015-2025
Henry Ford Hospital
2004-2021
Henry Ford Health System
2005-2021
Tata Memorial Hospital
2020
Université de Sherbrooke
2020
Ferdowsi University of Mashhad
2018
University of Tehran
2015-2017
Max Planck Institute for Intelligent Systems
2015-2017
Heidelberg (Poland)
2016
The synthesis and characterization of a novel nanocomposite is reported that was developed as an efficient adsorbent for the removal toxic methylene blue (MB) methyl violet (MV) from aqueous solution. comprises hydrolyzed polyacrylamide grafted onto xanthan gum well incorporated nanosilica. exploits saponification in situ formation nanoscale SiO2 by sol–gel reaction, which biopolymer matrix promotes silica polymerization therefore acts template nanosilica formation. detailed investigation...
We introduce a new hyaluronidase-responsive amphiphilic block copolymer system, based on hyaluronic acid (HYA) and polycaprolactone (PCL), that can be assembled into polymersomes by an inversed solvent shift method. By exploiting the triggered release of encapsulated dye molecules, these HYA-block-PCL lend themselves as autonomous sensing system for detection presence hyaluronidase, which is produced among others pathogenic bacterium Staphylococcus aureus. The synthesis enzyme-responsive...
Abstract Protein corona significantly affects in vivo fate of nanoparticles including biodistribution and half-life. Without manipulating the physicochemical properties with considering their biointerference, attaining effective treatment protocols is impossible. For this reason, protein evolution different chitosan (Ch)-based Ch carboxymethyl dextran (CMD)/thiolated (TD) polyelectrolyte complexes (PECs) were studied using highly precious sensitive methods such as liquid...
Surface functionalization strategies for targeting nanoparticles (NP) to specific organs, cells, or organelles, is the foundation new applications of nanomedicine drug delivery and biomedical imaging. Interaction NPs with biological media leads formation a biomolecular layer at surface so-called as "protein corona". This corona can shield active molecules cause mistargeting unintended scavenging by liver, kidney, spleen. To overcome this issue, we have designed biotin-cysteine conjugated...
Protein unfolding induced by nanoparticles (NPs) can lead to exposure of cryptic epitopes that might dictate biological identity and affect NP fate (e.g., blood circulation time, biodistribution, tumor accumulation). Here, we monitor the conformation fluorescence resonance energy transfer (FRET)-labelled fibronectin (FN) on corona-coated gold NPs. We found labelled FN proteins, which directly accessed surface, underwent more pronounced conformational changes than those associated with...
EMT-type zeolite nanoparticles (EMT NPs) with particle size of 10-20 nm and external surface area 200 m2/g have shown high selective affinity toward plasma protein (fibrinogen). Besides, the EMT NPs demonstrated no adverse effect on blood coagulation hemostasis. Therefore, it was envisioned that could inhibit possible β-amyloid (Aβ)-fibrinogen interactions result in formation structurally abnormal clots, which are resistant to lysis, cerebral vessels patients Alzheimer disease (AD). To...
Mesenchymal stem cells (MSCs)-based treatment strategy has shown promise in bolstering the healing process of chronic wounds diabetic patients, who are at risk amputation and mortality. To overcome drawbacks suboptimal cell retention diminished viability injury site, a novel nanofibrous biomaterial-based scaffold was developed by using controlled extrusion polymeric solution to deliver (human adipose-derived MSCs (ADMSCs) placenta-derived (PLMSCs)) locally animal model ulcers. The...
It is well understood that patients with different diseases may have a variety of specific proteins (e.g., type, amount, and configuration) in their plasmas. When nanoparticles (NPs) are exposed to these plasmas, the resulting coronas incorporate some disease-specific proteins. Using gold (Au) NPs surface properties corona composition, we developed technology for discrimination detection two neurodegenerative diseases, Alzheimer's disease (AD) multiple sclerosis (MS). Applying techniques,...
The objective of the present study is to conjugate L-thyroxine PEI derivative onto another compensate amine content whole structure which has been utilized for ligand conjugation. Since αvβ3 integrin receptors are over-expressed on cancer cells and there binding site these receptors, conjugation by along with restoring might be an efficient strategy targeted delivery using polymeric nanoparticles. results demonstrated ability in formation nanoparticles size around 210 nm higher buffering...
Introduction: Through sense of coherence, it can be justified why someone go through a high level stress and stay healthy. Aim: Current research was done to edit the pattern self-cohesion promotion during old age. Methods: The current qualitative type with method grand theory. population all elderly people between 60 65 years metaphorical network member (Sen Kamal), in 2022/10 were selected by targeted sampling method. data collected semi-structured interviews analyzed three stages open,...